Epidemiology of urological infections: a global burden

Öztürk, Recep; Murt, Ahmet

doi:10.1007/s00345-019-03071-4

Cited by 167 publications

(133 citation statements)

References 74 publications

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“…Bacterial adhesion, colonization, and biofilm formation on medical devices are responsible for a large proportions of nosocomial infections, and biomaterial-associated infections are common post-operative [ 1 , 2 , 3 , 4 ]. Catheter-associated urinary tract infections (CAUTI) are the most common hospital acquired bacterial infection and are associated with increased mortality and morbidity [ 5 ]. The gram negative bacterium Escherichia coli ( E. coli ) is the most frequent cause of CAUTIs [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Adhesion of Escherichia Coli to Nanostructured Surfaces and the Role of Type 1 Fimbriae

et al. 2020

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Bacterial fimbriae are an important virulence factor mediating adhesion to both biotic and abiotic surfaces and facilitating biofilm formation. The expression of type 1 fimbriae of Escherichia coli is a key virulence factor for urinary tract infections and catheter-associated urinary tract infections, which represent the most common nosocomial infections. New strategies to reduce adhesion of bacteria to surfaces is therefore warranted. The aim of the present study was to investigate how surfaces with different nanotopography-influenced fimbriae-mediated adhesion. Surfaces with three different nanopattern surface coverages made in polycarbonate were fabricated by injection molding from electron beam lithography nanopatterned templates. The surfaces were constructed with features of approximately 40 nm width and 25 nm height with 100 nm, 250 nm, and 500 nm interspace distance, respectively. The role of fimbriae type 1-mediated adhesion was investigated using the E. coli wild type BW25113 and ΔfimA (with a knockout of major pilus protein FimA) and ΔfimH (with a knockout of minor protein FimH) mutants. For the surfaces with nanotopography, all strains adhered least to areas with the largest interpillar distance (500 nm). For the E. coli wild type, no difference in adhesion between surfaces without pillars and the largest interpillar distance was observed. For the deletion mutants, increased adhesion was observed for surfaces without pillars compared to surfaces with the largest interpillar distance. The presence of a fully functional type 1 fimbria decreased the bacterial adhesion to the nanopatterned surfaces in comparison to the mutants.

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Section: Introductionmentioning

confidence: 99%

Adhesion of Escherichia Coli to Nanostructured Surfaces and the Role of Type 1 Fimbriae

et al. 2020

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“…This special topic issue on infections in urology features works from scientists, infectious disease specialists, and urologists. As seen in this work, there is still a noticeable heterogeneity in the global burden of the disease [1]. Indeed, while deficiencies in health systems and documentation restrict our epidemiological knowledge, the disease's epidemiology is changing with globalization and increasing migration events.…”

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confidence: 85%

Infections in urology: slow progress reflected in clinical practice

Güven

Mert

2020

World J Urol

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“…The urinary system is the most vital organ system, responsible for the drainage of urine and for the maintenance of homeostasis [1] via regulation of the blood volume, pressure, and pH and of metabolites and electrolytes [2]. The urinary system comprises the kidneys removing wastes and water from the blood in the form of urine [3] that is carried towards the bladder where it gets stored before leaving the body via the urethra [4].…”

Section: Introductionmentioning

confidence: 99%

Nanomaterials for the Diagnosis and Treatment of Urinary Tract Infections

et al. 2021

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The diagnosis and treatment of urinary tract infections (UTIs) remain challenging due to the lack of convenient assessment techniques and to the resistance to conventional antimicrobial therapy, showing the need for novel approaches to address such problems. In this regard, nanotechnology has a strong potential for both the diagnosis and therapy of UTIs via controlled delivery of antimicrobials upon stable, effective and sustained drug release. On one side, nanoscience allowed the production of various nanomaterial-based evaluation tools as precise, effective, and rapid procedures for the identification of UTIs. On the other side, nanotechnology brought tremendous breakthroughs for the treatment of UTIs based on the use of metallic nanoparticles (NPs) for instance, owing to the antimicrobial properties of metals, or of surface-tailored nanocarriers, allowing to overcome multidrug-resistance and prevent biofilm formation via targeted drug delivery to desired sites of action and preventing the development of cytotoxic processes in healthy cells. The goal of the current study is therefore to present the newest developments for the diagnosis and treatment of UTIs based on nanotechnology procedures in relation to the currently available techniques.

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Epidemiology of urological infections: a global burden

Cited by 167 publications

References 74 publications

Adhesion of Escherichia Coli to Nanostructured Surfaces and the Role of Type 1 Fimbriae

Adhesion of Escherichia Coli to Nanostructured Surfaces and the Role of Type 1 Fimbriae

Infections in urology: slow progress reflected in clinical practice

Nanomaterials for the Diagnosis and Treatment of Urinary Tract Infections

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