Epidemiology of urinary tract infection in neonatal intensive care unit: A single center study in Egypt

Youssef, Doaa Mohammed; Elfateh, Hanaa Abd; Sedeek, Randa; Seleem, Sherif

doi:10.4103/2249-4855.104012

Cited by 9 publications

(12 citation statements)

References 13 publications

(17 reference statements)

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“…In our study E. coli and Klebsiella were the most common causes of UTIs in early and late onset sepsis, which is consistent with other previous studies (27,28,30), yet unlike previous studies, they have high resistance rates to aminoglycosides (Tables 3 and 4). In the case of cephalosporins, they have acceptable susceptibility to cefotaxime (73.4% for E. coli and 81.5% for Klebsiella), but are resistant to ceftriaxone in 40% and 59.2% of cases, respectively which is also in contrast with previous studies (30)(31)(32)(33).…”

Section: Urinesupporting

confidence: 81%

“…While in some studies patients were selected only from NICU admitted neonates, who are more susceptible to infection, in other studies nursery admitted neonates (as our study) and even outpatient neonates were also included. The difference probably reflects variations in population characteristics and in predisposing factors (28). Method of sample collection (only suprapubic aspiration or samples collected with a bag) was also very important.…”

Section: Urinementioning

confidence: 99%

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Prevalence and Antibiotic Resistance of Neonatal Sepsis Pathogens in Neyshabour, Iran

Behmadi

Borji

Taghavi-Rad

et al. 2016

Arch Pediatr Infect Dis

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Background: Neonatal sepsis is a systemic inflammatory response syndrome that is secondary to infection. It is a major cause of neonatal mortality in the world, particularly in developing countries. A definitive diagnosis requires the isolation of pathogens from a normally sterile body site, including blood, cerebrospinal fluid and urine. Empirical antibiotic therapy is based on the physician's knowledge of the anticipated bacterial species and their expected antibiotic susceptibilities. Objectives: The aim of this study was to determine the prevalence and evaluate the antimicrobial susceptibility patterns of bacterial infections at a neonatal unit. Patients and Methods:This study was conducted at the neonatal intensive care unit and neonatal ward of Hakim hospital, Neyshabour, Iran. Blood, cerebrospinal fluid (CSF) and urine specimens were collected before institution of empirical antibiotic therapy. Antibiotic resistance pattern of the isolates was studied by the disc diffusion technique. Results: Coagulase-negative staphylococci (CoNS) were the most prevalent pathogens isolated from blood specimens in early and late-onset disease. Escherichia coli and Klebsiella were the most causative pathogens in early and late-onset urinary tract infections. They had high resistance to our empirical antibiotic regimens. Prevalence of bacterial meningitis was low in our study. Conclusions: Due to the increasing resistance of pathogens to usual empirical antibiotics, it is reasonable to stress upon preventive measures, so that a minimum number of neonates develop sepsis.

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Section: Urinesupporting

confidence: 81%

Section: Urinementioning

confidence: 99%

Prevalence and Antibiotic Resistance of Neonatal Sepsis Pathogens in Neyshabour, Iran

Behmadi

Borji

Taghavi-Rad

et al. 2016

Arch Pediatr Infect Dis

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“…UTI is one of the most important clinical problems in infancy that early diagnosis and appropriate treatment are very important because if the infection is untreated, it will lead to high blood pressure, recurrent infections, and kidney failure. 10,11 This study showed that the most frequent clinical signs in infants with urinary tract infection were prolong jaundice, fever, nausea and vomiting, and poor feeding, respectively. In Nickavar's study, 12 the most frequent signs were jaundice, irritability, poor feeding, vomiting, lethargy, fever, and tachypnea.…”

Section: Discussionmentioning

confidence: 94%

“…The results of this study were consistent with the aforementioned studies. Although fever was the most frequent sign of urinary tract infection among infants in the study conducted by Youssef et al 11 and Littlewood et al, 14 it seems that prolonged jaundice had been a clue to evaluate the infants for urinary tract infection.…”

Section: Discussionmentioning

confidence: 95%

Urinary tract infection profile among a hospitalized newborn: a single center study in Iran, 2006-2015

et al. 2018

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Background: Urinary tract infection in infants is associated with septicemia and genitourinary anomalies. This study was aimed at investigating the frequency, clinical signs, and anomalies in infants hospitalized for urinary tract infection.Methods: This cross-sectional study was conducted on all infants with urinary infection who were hospitalized in the neonatal ward of Be’sat Hospital from 2006 to 2015.Results: Of 79 infants with urinary infection, 62% were male and 87.3% were term infants. The mean age at admission was 16.62±7.17 days, and the mean weight was 3276±478.23 grams. The most frequent clinical sign and the most common pathogen reported were prolonged jaundice (62%) and Escherichia coli (69.6%), respectively. Of the samples, 93.7% were obtained by suprapubic aspiration, 23% had leukocytosis, and 2.5% had urosepsis. In urinalysis examination, 81% had pyuria and 19% had positive nitrate. Among 25.3% infants who had abnormal ultrasound findings, the most abnormal finding was mild bilateral hydronephrosis and 6.3% of the infants had abnormal voiding cystourethrogram (VCUG) in which vesicoureteral reflux was the most frequent finding.Conclusion: It showed that a prolonged jaundice in infants should be considered as a strong factor predicting urinary tract infection.

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“…Morbidity associated with pyelonephritis may be associated with clinical sepsis as has been highlighted by Youssef et al in this issue. [8] Long-term complications of pyelonephritis are hypertension, impaired kidney function, end-stage renal disease, and complications of pregnancy (e.g., UTI, pregnancy-related hypertension, low-birth-weight neonates). [9] Manisha Sahay…”

Section: Prognosismentioning

confidence: 99%

Urinary tract infections in children: Consensus and controversies

Sahay

2012

J Acad Med Sci

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and to the bloodstream (bacteremia). Bacterial infections are the most common cause of UTI, with E. coli being the most frequent (75-90%) of UTIs. Other bacterial sources include the following: Klebsiella species, Proteus species, Enterococcus species, Staphylococcus saprophyticus -especially among female adolescents and sexually active females, Streptococcus group B -especially among neonates, Pseudomonas aeruginosa, Fungi (Candida species) -especially after instrumentation of the urinary tract and rarely adenovirus. RISk FACToRS FoR InFeCTIon Host/Patient FactorsChildren younger than 5 years are predisposed to UTIs, because of periurethral colonization. These uropathogens are rare in children older than 5 years. Normal voiding results in complete washout of contaminating bacteria, pathogenic colonization of the urinary bladder is unlikely unless bladder defense mechanisms are impaired. Risk factors for UTI include anatomic anomaly (posterior urethral valves), voiding dysfunction (uninhibited detrusor contractions or neurogenic bladder), or constipation. Children who receive broad-spectrum antibiotics (e.g., amoxicillin, cephalexin) which alter gastrointestinal (GI) and periurethral flora are at an increased risk for UTI, because these drugs disturb the urinary tract's natural defense against colonization by pathogenic bacteria. The rate of UTIs in circumcised boys has been estimated at 0.2-0.4%, with the rate in uncircumcised boys being 5-20 times higher than in circumcised boys. In addition, some genes in humans may be associated with susceptibility to recurrent UTI. Also genetics may play a role in the progression of simple cystitis to pyelonephritis. Genetic testing may allow the identification of at-risk individuals and, therefore, prediction of genetic recurrences in their offspring. Non-secretors of P blood group antigen are also predisposed to UTI.

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Epidemiology of urinary tract infection in neonatal intensive care unit: A single center study in Egypt

Cited by 9 publications

References 13 publications

Prevalence and Antibiotic Resistance of Neonatal Sepsis Pathogens in Neyshabour, Iran

Prevalence and Antibiotic Resistance of Neonatal Sepsis Pathogens in Neyshabour, Iran

Urinary tract infection profile among a hospitalized newborn: a single center study in Iran, 2006-2015

Urinary tract infections in children: Consensus and controversies

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