Epidemiology of uncontrolled epilepsy in the Al-Kharga District, New Valley, Egypt

Farghaly, Wafaa Ma; El-Tallawy, Hamdy N; Rageh, Tarek A.; Mohamed, Eman M.; Metwally, Nabil A; Shehata, Ghaydaa A.; Badry, Reda; Abdelhamed, Mohamed A.

doi:10.1016/j.seizure.2013.04.010

Cited by 34 publications

(34 citation statements)

References 23 publications

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“…Our results agree with previous reports indicating that head injuries [14] are the most common underlying etiological cause of chronic epilepsy, with males being at a greater exposure risk. When comparing our results with another Egyptian study, led by Farghaly and his colleagues [35], they found that cerebrovascular stroke, rather than trauma, was the most common cause of symptomatic epilepsy among adults and the elderly while perinatal insults were the most common among children (< 18 years). This difference regarding adult epileptic patients may be related to the geographic characteristics as the mentioned study was carried out in Al-kharga District (New Valley), at the southern part of Egypt, where the majority live in rural areas with a density of 0.58/km 2 , while the majority of our subjects came from Giza, the third-largest city in Egypt and the world's seventh largest suburb, with a density of 2.300/km 2 , and the highest number of traffic accidents as reported by The Central Agency for Public Mobilization and Statistics [15].…”

Section: Etiological Causes Of Symptomatic Epilepsysupporting

confidence: 51%

Sex differences among epileptic patients: a comparison of epilepsy and its impacts on demographic features, clinical characteristics, and management patterns in a tertiary care hospital in Egypt

Kishk

Mourad

Ibrahim

et al. 2019

Egypt J Neurol Psychiatry Neurosurg

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Background: Epilepsy is one of the most common neurological conditions. We aimed to identify sex differences in the demographic, clinical features, and treatment strategies in epileptic patients. Objectives: To analyze and compare the differences in the impact of epilepsy on the socio-demographic characteristics of male and female patients along with gender differences in various types of epilepsies and treatment strategies. Material and methods: A record-based study for 1000 individuals attending the epilepsy outpatient clinic. The medical records were reviewed through a predesigned questionnaire to obtain all relevant data. Statistical analysis: Data was summarized using range, mean, standard deviation, and median interquartile range for quantitative variable or frequency and percentage for the qualitative ones. Comparison between groups was done using chi-square test. Results: Females were more illiterate and unemployed compared to males. Tonic-clonic seizures were more frequent in males. Specific epileptic syndromes as juvenile myoclonic epilepsy (JME) were more frequent in females (p = 0.01). More males had an underlying secondary etiology (p = 0.001). The most common drug used was valproate (51.2%) which was more utilized by males. Conclusions: Significant differences between both sexes were observed in certain social impacts in addition to seizure syndromes, etiology, and drug utilization.

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Section: Etiological Causes Of Symptomatic Epilepsysupporting

confidence: 51%

Sex differences among epileptic patients: a comparison of epilepsy and its impacts on demographic features, clinical characteristics, and management patterns in a tertiary care hospital in Egypt

Kishk

Mourad

Ibrahim

et al. 2019

Egypt J Neurol Psychiatry Neurosurg

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“…For example, the prevalence of early-onset cerebellar ataxia with retained tendon reflexes was lower in northwestern Italy (0.97/100,000 children) 7 compared with the Al-Kharga District in Egypt (3.92/ 100,000 children). 12 Ataxias attributable to environmental causes also varied by region. TAN 8,10 and ataxia as a complication of malaria [29][30][31] were only reported from Africa.…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, few studies separate the prevalence of ataxia in children vs adults. [4][5][6][7][8][9][10][11][12] Given the multitude of ataxia-causing conditions and recognizing that each can be quite rare, the overall prevalence of childhood ataxia is likely underestimated. Yet overall prevalence data are needed to accurately assess the impact and societal cost of childhood ataxia.…”

mentioning

confidence: 99%

Prevalence of ataxia in children

et al. 2014

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Objective: To estimate the prevalence of childhood ataxia resulting from both genetic and acquired causes.Methods: A systematic review was conducted following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) statement. Five databases were searched for articles reporting a frequency measure (e.g., prevalence, incidence) of ataxia in children. Included articles were first grouped according to the World Health Organization (WHO) regions and subsequently classified according to etiology (genetic, acquired, or mixed). Each article was assessed for its risk of bias on the domains of sampling, measurement, and analysis. Incidence values were converted to prevalence estimates whenever possible. European prevalence estimates for different etiologies of ataxia were summed to gauge the overall prevalence of childhood ataxia.Results: One hundred fifteen articles were included in the review. More than 50% of the data originated from the Europe WHO region. Data from this region also showed the least susceptibility to bias. Little data were available for Africa and Southeast Asia. The prevalence of acquired ataxias was found to vary more greatly across regions than the genetic ataxias. Ataxic cerebral palsy was found to be a significant contributor to the overall prevalence of childhood ataxia across WHO regions. The prevalence of childhood ataxias in Europe was estimated to be ;26/100,000 children and likely reflects a minimum prevalence worldwide. Conclusions:The findings show that ataxia is a common childhood motor disorder with a higher prevalence than previously assumed. More research concerning the epidemiology, assessment, and treatment of childhood ataxia is warranted. Ataxia refers to a lack or loss of movement coordination. It is associated with damage or dysfunction of the cerebellum or its afferent and efferent projections.1 Ataxia is especially debilitating for children because they are still developing and learning motor competency. The prevalence of some ataxia-causing conditions has been reported. However, most reports are focused on a single condition and a specific geographical location, making it difficult to generalize the prevalence estimates. Furthermore, few studies separate the prevalence of ataxia in children vs adults. [4][5][6][7][8][9][10][11][12] Given the multitude of ataxia-causing conditions and recognizing that each can be quite rare, the overall prevalence of childhood ataxia is likely underestimated. Yet overall prevalence data are needed to accurately assess the impact and societal cost of childhood ataxia.The purpose of this article is to systematically review the literature on the prevalence of ataxia in children across World Health Organization (WHO) regions. The prevalence of childhood From the Department of Neuroscience

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“…Video monitoring EEG of compliant uncontrolled patients demonstrated that 78.1% patients (n = 50 / 64) had definite epilepsy, while 21.9% (n = 14 / 64) had psychogenic non-epileptic seizures (PNES). A logistic regression analysis revealed that status epilepticus, focal seizures, and mixed seizure types were risk factors for intractability [36]. Uncontrolled epilepsy leads to more stigmatization upon patient with epilepsy.…”

Section: Uncontrolled Epilepsymentioning

confidence: 98%

A Review of Epilepsy Stigma in Egypt

Shehata¹

2016

Acta Psychopathologica

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Epidemiology of uncontrolled epilepsy in the Al-Kharga District, New Valley, Egypt

Cited by 34 publications

References 23 publications

Sex differences among epileptic patients: a comparison of epilepsy and its impacts on demographic features, clinical characteristics, and management patterns in a tertiary care hospital in Egypt

Sex differences among epileptic patients: a comparison of epilepsy and its impacts on demographic features, clinical characteristics, and management patterns in a tertiary care hospital in Egypt

Prevalence of ataxia in children

A Review of Epilepsy Stigma in Egypt

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