Epidemiology of Squamous Cell Carcinoma of the Oral Cavity in Iran

Abstract

Squamous cell carcinoma accounts for approximately 90% of oral malignancies. This study was performed to determine the prevalence of oral squamous cell carcinoma (OSCC) in southern Iran in relation to sex, age, subsite distribution, and histologic differentiation of the tumor. Pathologic records of patients with a histologic diagnosis of OSCC at Fars Cancer Registry of Nemazee Hospital affiliated to Shiraz University of Medical Sciences during the period of April 1992 through March 2007 were reviewed. Among 11,220 cases of cancer registered during this period, 200 cases were OSCC (1.7%). The age range of patients was 4 to 87 years (mean, 56.9 years; SD, 15.5 years), with a 1.4:1 male-female ratio. Oral squamous cell carcinoma occurred more frequently in patients older than 60 years. The tongue was the most commonly affected site (53%), followed by the buccal mucosa (9.5%) and maxillary gingiva (9%). The well-differentiated type (55.5%) was the most common, with the poorly differentiated OSCC being the least common (7.5%). The present study showed that OSCC was the most common malignancy in the tongue and buccal mucosa being more common in older age and male sex.

Clinical and histopathological analysis of oral Squamous cell carcinoma of young patients in Mashhad, Iran: A retrospective study and review of literature

“…It was compatible with other studies in Iran (10)(11)(12) ment. This difference seems to be related to different habits (5,12). None of our cases had a special risk factor or habit.…”

“…Although the incidence of OSCC in patients less than 40 is low, we encountered 21 cases out of a total number of 158 cases (13%) in Mashhad Dental Faculty during a 13 years period (from 1996 to 2009). Similar studies in Iran showed approximately the same results; ranging 11%-15% of patients in Shiraz and Tehran and 21.6 % in Kerman (10)(11)(12). Oral cancer is predominantly a disease of men in all age groups (2,3) as we noticed in our study, but some studies revealed a female predilection in young patients with OSCC (4,6).…”

An Analysis of Biopsy-proven Tongue Lesions among 8,105 Dental Outpatients

“…Irritation fibroma occurred in 14.4% of our samples which is similar to the 14.6% presented by Barker and Lucas, 33 but less than that found by Toida et al 24 Considering that irritation fibroma can be affected by oral habits, 34 which in turn are known to be related to social stress and cultural factors, this element may have a role in the differences observed between populations. Squamous cell carcinoma showed a prevalence of 13.8% in the current investigation which falls at the lower end of the 10.7 to 53% 27,[35][36][37] reported in other studies. There is a long list of items affecting the occurrence of squamous cell carcinoma ranging from the use of tobacco to phenolic agents and a number of systemic diseases 19 which can be responsible for these variations.…”

Effectiveness of an Intervention Program on Knowledge of Oral Cancer among the Youth of Jazan, Saudi Arabia

“…If major cancers such as breast, skin, testis, prostate, uterus and urinary bladder are considered; oral cancer ranks among the ones with the lowest survival rate (Pisani et al, 1999), with a mean value of 0.54 for females and 0.41 for males (Berrino et al, 2003). It ranks second, next to cardiovascular disease in causing death among the population (Andisheh-Tadbir et al, 2008). According to the World Health Organization (WHO), the rate of people dying due to untreated oral cancer accounts for 2 in 100,000 (UK, 2013) of which 90%-95% are Squamous cell carcinomas (SCC's) (Ame´zaga et al, 2007).…”