Epidemiology of sporotrichosis: A study of 304 cases in Brazil

Rosa, André Ricardo Pereira da; Scroferneker, Maria Lúcia; Vettorato, Rodrigo; Gervini, Roberto Lopes; Vettorato, Gérson; Weber, Analupe

doi:10.1016/j.jaad.2004.11.046

Cited by 156 publications

(142 citation statements)

References 48 publications

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“…Sporotrichosis, a disease caused by the thermally dimorphic fungus Sporothrix schenckii, is an emergent infection in immunocompromised hosts and is considered as an endemic mycosis in Mexico, Costa Rica, Guatemala, Colombia, Brazil, Uruguay, South Africa, India and Japan (Bustamante & Campos, 2001;Rosa et al, 2005;Schubach et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

TGF-β1 induces transendothelial migration of the pathogenic fungus Sporothrix schenckii by a paracellular route involving extracellular matrix proteins

et al. 2007

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Sporotrichosis, a mycosis caused by Sporothrix schenckii, is characterized by lymphocutaneous lesions. In immunocompromised hosts, this fungus may invade the bloodstream and disseminate to other tissues, such as lung and bone. Our group previously showed that S. schenckii yeasts adhere to endothelial monolayers and that this interaction is modulated by cytokines. Using 3.0 mm-pore culture inserts, the present work shows that transforming growth factor (TGF)-b1 led to a 80±26 % increase in fungal migration across endothelial monolayers and inhibited fungus internalization by 55±23.5 %, when compared to untreated cells. The major surface endothelial molecules recognized by S. schenckii were not modulated by TGF-b1. These data suggested that a paracellular route is preferentially used by S. schenckii during the transmigration of cultured endothelial cells. It was further observed that TGF-b1 increased the subendothelial matrix exposure and that anti-fibronectin (anti-FN) and anti-laminin (anti-LM) antibodies abolished the increase in S. schenckii association with endothelial monolayers induced by TGF-b1. These antibodies also inhibited (38.2±4.29 % and 50.8±17.3 %, respectively) the adhesion of S. schenckii to freshly prepared native endothelial matrices. Furthermore, transendothelial migration of S. schenckii was blocked by anti-FN and anti-LM antibodies. These data indicate that TGF-b1-induced S. schenckii adhesion to endothelial monolayers results from the increased exposure of the subendothelial extracellular matrix and that this event may contribute to the enhancement of transendothelial migration.

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Section: Introductionmentioning

confidence: 99%

TGF-β1 induces transendothelial migration of the pathogenic fungus Sporothrix schenckii by a paracellular route involving extracellular matrix proteins

et al. 2007

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“…S. Schenckii is uncommon opportunistic in HIV -infected individuals, but disseminated sporotrichosis has been seen in patients with AIDS . [9] Clinical cases of Sporotrichosis have been classified into lymphangitic or lymphocutaneous lesions, localized or fixed type, multifocal or disseminated and extracutaneous types by Sampaio and Lacaz [10] Clinical manifestations most commonly include cutaneous with papulonodular lesions and lymphocutaneous forms (adenopathy and lymphangitic spread) of the infection. Rarely the infection involves the joints.…”

Section: Discussionmentioning

confidence: 99%

A Case Report of Rare Fungal Lesion

2017

IJCRR

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Aim: Sporotrichosis is a common subcutaneous mycotic fungal infection caused by the dimorphic fungus sporothrixschenkii Case Report: Here we report a rare case, 50 years old male, farmer by occupation presented with history of pain and swelling both the forearms for a duration of 6 months. Diagnosed with Sporotrichosis fungal infection on tissue biopsy.Discussion: Sporotrichosis is a rare, acute or chronic fungal infection caused by the dimorphic fungus sporothrixschenkii. Infection commonly results from percutaneous inoculation of infected wood splinters or thorns. Farmers, florist and gardeners are most usually affected. In our case also patient was a farmer by occupation. Sporotrichosis is a slowly progressive disease and initial symptom may appear 1 to 12 weeks after the exposure to the fungus. Conclusion:As Sporotrichosis is an uncommon fungal disease awareness of this disease and an extensive environmental study is required to understand the actual burden of the disease.

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“…2,4 Rosa and collaborators classified the south region of Brazil as an endemic area for sporotrichosis. 5 The classic transmission of the disease is via traumatic inoculation of the fungus into the skin through contact with contaminated material. The disease is sometimes classified as an occupational hazard and professionals like florists, horticulturists, gardeners and miners have a higher risk of getting infected.…”

Section: Discussionmentioning

confidence: 99%

Ocorrência familiar de esporotricose zoonótica

Cordeiro

Bruno

Paula

et al. 2011

An. Bras. Dermatol.

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Abstract:Sporotrichosis is a suba cu te or chro nic myco sis cau sed by the dimor phic fun gus Sporothrix schenc kii which is ende mic in Brazil and is trans mit ted pri ma rily through trau ma tic ino cu la tion of its causa ti ve agent into the skin. The zoo no tic trans mis sion, espe cially from infec ted cats, has been demons trated in seve ral reports and case series. We pre sent simul ta neous occur ren ce of the disea se in three members of the same family by scrat ches from an infec ted domes tic cat. Two patients deve lo ped the lympho cuta neous form and one only deve lo ped the fixed cuta neous form. Two patients were suc cess fully trea ted with satu ra ted solu tion of potas sium iodi de; howe ver, the third case repor ted side effects and had his therapy subs ti tu ted for itra co na zo le, with reso lu tion of his lesions. Keywords: Cats; Disease trans mis sion, infec tious; Potassium iodi de; Sporotrichosis Resumo: A espo ro tri co se é mico se suba gu da ou crô ni ca, cau sa da pelo fungo dimór fi co Sporothrix schenckii, endê mi ca no Brasil e trans mi ti da prin ci pal men te atra vés da ino cu la ção trau má ti ca de seu agen te cau sal na pele. A trans mis são zoo nó ti ca, espe cial men te por gatos infec ta dos, tem sido demons tra da em diver sos rela tos e séries de casos. Nós des cre ve mos a ocor rên cia simul tâ nea da doen ça em três mem bros de uma mesma famí lia atra vés da arra nha du ra por gato domés ti co infec ta do. Dois pacien tes desen vol ve ram a forma cutâ nea-lin fá ti ca e ape nas um desen vol veu a forma cutâ nea fixa. Dois pacien tes foram tra ta dos com sucesso, com solu ção satu ra da de iode to de potás sio; entre tan to, o ter cei ro caso apre sen tou efei tos cola te rais e teve seu tra ta men to subs ti tuí do por itra co na zol, com reso lu ção de suas lesões. Palavras-chave: Esporotricose; Gatos; Iodeto de potás sio; Transmissão de doen ça infec cio sa

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Epidemiology of sporotrichosis: A study of 304 cases in Brazil

Cited by 156 publications

References 48 publications

TGF-β1 induces transendothelial migration of the pathogenic fungus Sporothrix schenckii by a paracellular route involving extracellular matrix proteins

TGF-β1 induces transendothelial migration of the pathogenic fungus Sporothrix schenckii by a paracellular route involving extracellular matrix proteins

A Case Report of Rare Fungal Lesion

Ocorrência familiar de esporotricose zoonótica

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