Epidemiology of Spontaneous Abortions- The Effect of Previous Abortions

Anokute, Charles C.

doi:10.1177/146642408710700114

Cited by 10 publications

(16 citation statements)

References 10 publications

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“…No specific pattern of malformations was seen within the observed birth defects. The rate of spontaneous abortions was consistent with the general population [26–28]. …”

Section: Discussionsupporting

confidence: 80%

“…The spontaneous abortion rate of patients in the Registry (9.0 %) was lower than that observed in the general population (13.1–15.9 %) [26, 27] and consistent with a longitudinal study of untreated pregnant women with MS (9.8 %) [28]. The background rate for spontaneous abortion is difficult to identify with precision, and spontaneous abortions were not captured prior to Registry enrollment, which may present a bias resulting in the underestimation of the true spontaneous abortion rate.…”

Section: Discussionmentioning

confidence: 99%

“…Corresponding 95 % confidence intervals (C. I.s) were calculated for major birth defect and spontaneous abortion rates. Spontaneous abortion rates in the Registry were compared with general population rates reported in published literature [26–28]. …”

Section: Methodsmentioning

confidence: 99%

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Evaluation of pregnancy outcomes from the Tysabri® (natalizumab) pregnancy exposure registry: a global, observational, follow-up study

et al. 2016

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BackgroundPatients with multiple sclerosis (MS) or Crohn’s disease (CD) being treated with natalizumab (Tysabri®, Biogen) who are planning to become pregnant or discover they are pregnant after exposure to natalizumab are currently advised to balance the potential benefits and potential risks of exposure when considering treatment options. This study was undertaken to evaluate pregnancy outcomes of women with MS or CD who were exposed to natalizumab at any time within 3 months prior to conception or during pregnancy. A pregnancy registry was created to better understand the effect of natalizumab exposure on pregnancy outcomes.MethodsThe Tysabri Pregnancy Exposure Registry was a global, observational exposure registration and follow-up study. Evaluations included spontaneous abortions (<22 weeks gestational age), fetal losses (≥22 weeks gestational age), ectopic pregnancies, elective or therapeutic terminations, stillbirths, birth defects, and live births. Birth defects were reviewed and coded in accordance with the Metropolitan Atlanta Congenital Defects Program (MACDP) classification of birth defects.ResultsA total of 369 patients with MS and 7 patients with CD were enrolled prospectively, of whom 355 patients (99.4 %; 349 MS and 6 CD) had known pregnancy outcomes (including 8 twin sets). The spontaneous abortion rate was 9.0 % (n = 32; 95 % confidence interval [C. I.], 6.3–12.5 %). An independent advisory committee review determined the major birth defect rate to be 5.05 % (16 of 316 live births + 1 elective abortion; 95 % C. I., 2.9–8.1 %). The mean gestational age of the live-born infants was 38.3 weeks, and the mean birth weight was 3158.3 g.ConclusionsAlthough the overall rate of birth defects was higher than that observed by the MACDP, these registry outcomes showed no specific pattern of malformations that would suggest a drug effect, and the spontaneous abortion rate was consistent with that of the general population.Trial registrationClinicalTrials.gov NCT00472992 (11 May 2007).

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“…No specific pattern of malformations was seen within the observed birth defects. The rate of spontaneous abortions was consistent with the general population [26–28]. …”

Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

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Evaluation of pregnancy outcomes from the Tysabri® (natalizumab) pregnancy exposure registry: a global, observational, follow-up study

et al. 2016

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“…The consumption of one drink 2-6 times a week to 1-2 drinks daily have had an effect in some studies (62)(63)(64). In one study a drink once or more than once a week was significantly associated with an excess of spontaneous abortion, but a drink 1-3 times a month was not (65).…”

Section: Alcohol Consumption and Smokingmentioning

confidence: 99%

“…Smoking was shown to have a positive association with spontaneous abortion in several studies (44). In some studies the effects have been found among women smoking 10 cigarettes/d (7) and in others only at higher exposure levels (64). Smoking has been' associated negatively with trisomy in abortuses of women under 30 years of age, but positively in abortuses of women over 30 years of age (68).…”

Section: Alcohol Consumption and Smokingmentioning

confidence: 99%