Epidemiology of sinonasal squamous cell carcinoma: A comprehensive analysis of 4994 patients

Abstract

The overall incidence of SNSCC is declining. However, survival has not significantly improved in the last 3 decades. Race seems to influence the overall survival of this tumor. Future studies need to be conducted to investigate these dynamic trends related to SNSCC.

Sinonasal Squamous Cell Carcinoma: A Review with Emphasis on Emerging Histologic Subtypes and the Role of Human Papillomavirus

“…Rates of sinonasal SCC have been decreasing in recent years [2]. Tumors occur predominantly in men (twice as commonly as in women) in their 50's and 60's.…”

“…Chief complaints are primarily nasal obstruction, facial pain, rhinorrhea, and epistaxis (bleeding). Approximately 50 % arise in the nasal cavity, and 50 % in the paranasal sinuses [2], predominantly the maxillary sinus. Tumor stage is not defined by size, but rather by number and types of local structures involved for early tumors and, for late ones, by invasion of adjacent structures including orbital soft tissue, skull base, brain, and/or facial/nasal skin, all of which constitute classification of tumors as T4.…”

“…The sinonasal tract (specifically the nasal cavity and paranasal sinuses), compared to other sites, has the lowest fraction of SCC relative to other carcinoma types (*65 to 70 %). Since the sinonasal tract is the primary site for only *3 to 5 % of all head and neck cancers [1], and since most of these tumors appear to be decreasing in incidence over time [2], this means that pathologists do not see very many of them in routine practice. It has also made it challenging to gather sufficient numbers of patients with these tumors for studies to define their morphology, molecular aspects, and proper treatment.…”

Diagnostic value of tumor blood flow and its histogram analysis obtained with pCASL to differentiate sinonasal malignant lymphoma from squamous cell carcinoma

“…Squamous cell carcinoma (SCC) is the most common tumor among nasal and sinonasal cavity malignancies [1]. Treatments for SCC include surgical treatment, chemotherapy, radiotherapy, and combinations of these [2].…”

Predictors of Survival in Sinonasal Adenocarcinoma

“…Similar results were shown in sinonasal squamous cell carcinoma, where blacks had worse 20-year survival than whites (19 vs. 31%). 13 Differences in outcomes by race with head and neck cancer have been attributed partly to differences in socioeconomic status and access to health care.…”