Epidemiology of severe sepsis in critically ill surgical patients in ten university hospitals in China*

Cheng, Baoli; Xie, Gary; Yao, Shouzhen; Wu, Xianxian; Guo, Qulian; Gu, Miao-ning; Fang, Qiang; Xu, Qiuping; Wang, Dong‐Xin; Jin, Yuqi; Yuan, Shiying; Wang, Junlu; Du, Zhenhong; Sun, Ying; Fang, Xiangming

doi:10.1097/01.ccm.0000284492.30800.00

Cited by 223 publications

(167 citation statements)

References 26 publications

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“…However results in this study were consistent with some of previous studies 29,30,31 . The reasons for the changes in the microbiological patterns of septicaemia in this study is probably a result of complex interactions involving patient's underlying conditions, the demographic and geographic factors, the extensive use of extendedspectrum antibiotics, less attention to sanitary precautions, the invasive interventions, and the quality of care provided.…”

Section: Etiological Agentssupporting

confidence: 83%

Prevalence of Septicaemia and Antibiogram of Different Etiological Agents in Patients of Intensive Care Units of a Tertiary Care Centre in Northern India

Mishra¹,

Verma²,

Joshi³

et al. 2013

Nepal J Epidemiology

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Section: Etiological Agentssupporting

confidence: 83%

Prevalence of Septicaemia and Antibiogram of Different Etiological Agents in Patients of Intensive Care Units of a Tertiary Care Centre in Northern India

Mishra¹,

Verma²,

Joshi³

et al. 2013

Nepal J Epidemiology

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“…A recent meta‐analysis of RCTs reported that the survival benefit of anticoagulant therapy was observed only in sepsis patients with DIC, but not in those without DIC 10. Furthermore, although many epidemiological studies for sepsis have been carried out,11, 12, 13, 14, 15 epidemiological data regarding sepsis in Japan is limited 16, 17…”

Section: Introductionmentioning

confidence: 99%

A summary of the Japan septic disseminated intravascular coagulation study

Hayakawa

Ono

2018

Acute Medicine & Surgery

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Over the past few decades, the large, international, randomized controlled trials of anticoagulant therapies for patients with sepsis have not yielded any improvement in mortality rates. However, in Japan, anticoagulant therapies are administered for sepsis patients with disseminated intravascular coagulation (DIC), but not for sepsis patients without DIC. Furthermore, epidemiological data regarding sepsis in Japan are scarce. Therefore, a nationwide multicenter retrospective observational study, the Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study, was undertaken. The JSEPTIC DIC study enrolled 42 intensive care units and included 3,195 patients with sepsis. The results of the JSEPTIC DIC study indicated the following: (i) anticoagulant therapy may be effective in sepsis‐induced DIC patients at high risk for death, (ii) recombinant human soluble thrombomodulin administration and antithrombin supplementation are associated with survival benefits in patients with sepsis‐induced DIC.

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“…The mortality rate of sepsis in ICU is 33%, whereas that of severe sepsis is as high as 50%. A multicenter epidemiology survey [1] shows that in China the occurrence rate of severe sepsis was 8.68% in ICU and the mortality rate was as high as 44.7%. The treatment of sepsis has become a worldwide problem in the modern critical care medicine.…”

Section: Introductionmentioning

confidence: 99%

The role of regulatory T cells in immune dysfunction during sepsis

Cao¹,

Ma²,

Chai³

et al. 2015

World Journal of Emergency Medicine

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BACKGROUND: Although regulatory T cells (Tregs) are key to the maintenance of immunologic homeostasis and tolerance, little is known about Treg-mediated immunosuppression in the stage of sepsis. This article aimed to review the current literature on the role of Tregs in the pathophysiology of septic response, attempting to investigate the role of Tregs in immune dysfunction during sepsis.DATA SOURCES: A literature search was conducted in January 2014 using the China National Knowledge Infrastructure and PubMed. Articles on the role of Tregs in immune dysfunction during sepsis were identifi ed. RESULTS:The identifi ed articles indicated that Treg levels can be used for the assessment of the course of sepsis. The inhibition of Treg activity can promote the recovery of immune function. CONCLUSION:Since the mechanism of Tregs is complex during the sepsis, more studies are needed.

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Epidemiology of severe sepsis in critically ill surgical patients in ten university hospitals in China*

Cited by 223 publications

References 26 publications

Prevalence of Septicaemia and Antibiogram of Different Etiological Agents in Patients of Intensive Care Units of a Tertiary Care Centre in Northern India

Prevalence of Septicaemia and Antibiogram of Different Etiological Agents in Patients of Intensive Care Units of a Tertiary Care Centre in Northern India

A summary of the Japan septic disseminated intravascular coagulation study

The role of regulatory T cells in immune dysfunction during sepsis

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