Epidemiology of sepsis in patients with traumatic injury

Have Severity Scores a Place in Predicting Septic Complications in ICU Multiple Trauma Patients?

“…The data was collected from a single center, and the population sample size was relatively small, both factors setting limits on the robustness of the research. Similar results have been reported in others studies [15][16][17], however Singh et al reported different findings. He used trauma and injury severity score (TRISS), a combination index based on revised trauma score (RTS), injury severity score (ISS) and patient's age to predict the outcome in trauma cases [18] and the performance of TS, ISS and TRISS as predictors of survival was evaluated using the misclassification rate, the information gain and the relative information gain.…”

Treatment of hemorrhagic shock with hypertonic saline solution modulates the inflammatory response to live bacteria in lungs

“…patients (11). In spite of all the improvements in intensive care, morbidity is still high and the best treatment seems to be prevention (4).…”

Sex Hormones and Bacterial Infections

“…In sepsis, an infectious process associated with systemic inflammatory response syndrome, large-scale studies reported higher incidence in men than in women (Angus et al, 2001;Martin et al, 2003;Pietropaoli et al, 2010). Men also develop more frequently sepsis episodes among patients with trauma (Osborn et al, 2004;Wafaisade et al, 2011) or acute kidney injury (Lopes et al, 2010). In addition, men are over-represented among patients with respiratory infections (Esper et al, 2006) or bloodstream infections (Laupland et al, 2004) (Table 1).…”

“…In contrast to susceptibility to bacterial infections, studying the role of sex in the mortality provided contrasting evidence. Some epidemiological studies did not report any gender differences in sepsis-related death (Crabtree et al, 1999;Martin et al, 2003;Laupland et al, 2004;Esper et al, 2006) whereas other found either increased mortality in men (Osborn et al, 2004;Melamed & Sorvillo, 2009;Wafaisade et al, 2011) or women (Combes et al, 2009;Pietropaoli et al, 2010;Nachtigall et al, 2011). As men are also at increased risk of death due to trauma, cancer and cardiovascular diseases as compared with women, the analysis of epidemiological data should integrate these potential biases (Micheli et al, 2009;Pinkhasov et al, 2010;Coronado et al, 2011).…”