Epidemiology of sepsis in intensive care units in Turkey: a multicenter, point-prevalence study

Baykara, Nur; Akalın, Halis; Arslantaş, Mustafa Kemal; Hancı, Volkan; Çağlayan, Çiğdem; Kahveci, Ferda; Demırağ, Kubilay; Baydemır, Canan; Ünal, Necmettin

doi:10.1186/s13054-018-2013-1

Cited by 89 publications

(86 citation statements)

References 42 publications

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“…With regard to the sepsis patients’ profile and focus of infection, Zanon et al 11 also observed a mean age of over 60 years and that the most prevalent infectious focus was the pulmonary one. Among the pathogens, Acinetobacter and Staphylococcus aureus were also frequently found, 12 being common pathogens of ventilator‐associated pneumonia (VAP). In fact, the use of mechanical ventilation in the ICU is frequent and exposes patients to the risk of developing pneumonia and consequently sepsis.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory markers in saliva for diagnosis of sepsis of hospitalizes patients

Galhardo

Ruivo

Oliveira

et al. 2020

Eur J Clin Investigation

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Background: Inflammatory/immunological serum markers are useful for the early detection of organ dysfunction, helping the diagnosis of sepsis. Although the detection of blood biomarkers is a standard practice, the use of noninvasive samples (eg saliva) would be beneficial. Aim: To investigate the saliva of hospitalized patients with and without sepsis and identify the levels of inflammatory markers such as C-reactive protein (CRP), procalcitonin (PCT), interleukin 6 (IL-6) and nitric oxide (NO). Methods: Saliva samples were collected from 26 patients in intensive care unit with diagnosis of sepsis and from 26 without sepsis (control). The levels of CRP were determined by using latex agglutination test, whereas those of procalcitonin and IL-6 by ELISA and NO by the Griess reaction. Results: Of 26 patients with sepsis, 14 were males (54%) with a mean age of 63.81 ± 3.48 years. The control group had the same distribution for gender, with mean age 65.04 ± 4.07 years. Sepsis group showed higher salivary concentrations of CRP, PCT, IL-6 and NO, with only levels of IL-6 being statistically different (P = .0001). Conclusions: Patients with sepsis had significantly higher levels of IL-6 in their saliva, suggesting that this biological sample could be useful in the diagnosis of this condition. K E Y W O R D Sbiomarkers, intensive care unit, saliva, sepsis

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Section: Discussionmentioning

confidence: 99%

Inflammatory markers in saliva for diagnosis of sepsis of hospitalizes patients

Galhardo

Ruivo

Oliveira

et al. 2020

Eur J Clin Investigation

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show abstract

“…Distribution of microorganisms detected, by culture type CNS, VRE, MRSAfound to be very high among patients with sepsis and septic shock in the ICU (55.7% and 70.4, respectively). The most isolated microorganism was Acinetobacter spp (33.7%) and approximately 74.8% of Acinetobacters were resistant to carbapenems(27). In our study, the rate of Acinetobacter spp in all Syrian patients was 9.3% and 23.6% in patients with sepsis.…”

mentioning

confidence: 46%

Reasons for Hospitalisation, Sepsis Development and Mortality Among Syrian Patients in an Intensive Care Unit

Orak¹,

Tanır²,

Güngör³

et al. 2021

tybd

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Objective: Our aim is to investigate causes of hospitalization of Syrian patients in an intensive care unit (ICU), development of sepsis, relevant reasons of pathogens and mortality rates. Materials and Methods: We carried out this study between 2012 and 2016. Patient information was analyzed retrospectively from records and files in the information system. Results: One hundred thirty-nine Syrian patients were hospitalized in an ICU during the study period. The most common ICU diagnoses were respiratory tract infection (29 patients: 20.9%) and trauma (26 patients: 18.7%). Of these patients, 35 were diagnosed with sepsis during their treatment in the ICU. Acinetobacter baumannii and E. coli were isolated in the culture of the patients with sepsis (17, 12, respectively). Acinetobacter baumannii was most common in tracheal cultures and E. coli in urine cultures. Additionally, seven patients were diagnosed with sepsis at their first application to the hospital. H1N1 in two, S. pneumoniae in three, H. influenzae in one, S. aureus and aspergilloma in another patient were detected. While 45 of 139 patients died, 28 of 35 patients diagnosed with sepsis died. APACHE II scores, duration of mechanical ventilation, number of days spent in ICU were all higher in the deceased patients than in the surviving patients (p<0.001, p<0.001, p<0.001). Conclusion: Respiratory diseases were the most common causes for Syrian patients' hospitalization in the ICU and developing sepsis. For these patients, sepsis was still an important factor for mortality.

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“…Ülkemizden kısa süre önce yayınlanan bir makalede, YBÜ'lerindeki enfeksiyon, sepsis ve septik şok hastalarının ancak %60'a yakınında bir etken izole edilebilmiş, küflerden sadece Aspergillus spp. raporlanmış, o da mikroorganizmaların ancak %0,3'ü olarak bildirilmiştir (12). Burada izole edilebilen etken oranının azlığına, İKE tanısı koymanın güçlüğüne ve klinik tabloların özgül olmamasına dikkat etmek gerekir.…”

Section: Epidemiyoloji: Risk Faktörleri Ve Etkenler Yönünden Genel Biunclassified

Yoğun Bakımlarda İnvazif Küf Enfeksiyonları: Epidemiyoloji, Mikrobiyolojik Tanı ve Antifungal Direnç

Sığ¹,

Akdağlı²

2019

Yoğun Bakım Derg

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Invasive fungal infections present with a rising incidence and high morbidity and mortality rates. Among these infections are those due to moulds which draw particular attention per the diagnostic difficulties and higher mortality rates. While a relative decrease is observed in mortality rates regarding the use of prophylactic, empirical or preemptive antifungal regimens, there is a tendency of increase in antifungal resistance rates. Furthermore, due to increase in number of cases with immunosuppression, infections caused by rare and emerging moulds are now more frequently observed. Breakthrough infections, nosocomial infections, and infections due to risk factors other than immunosuppression are also a clinical concern. Diagnosis of invasive mould infections requires a multidisciplinary approach with clinical, radiological, histopathological and microbiological data. However, nonspecificity of clinical signs and radiological findings and difficulties in differentiation of infection and colonization are major problems in patients with invasive mould infections in intensive care units. Limited availability of routine microbiology laboratories with adequate facilities in mycological diagnostics and problems in specificity and sensitivity of diagnostic tests for intensive care unit patients result in further difficulties in diagnosis of these infections. In this review article, epidemiological data and microbiological diagnostic methods for invasive mould infections in intensive care units were reviewed per the published reports and the recommendations of current guidelines. Finally, antifungal resistance and clinical impact of resistance were discussed.

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Epidemiology of sepsis in intensive care units in Turkey: a multicenter, point-prevalence study

Cited by 89 publications

References 42 publications

Inflammatory markers in saliva for diagnosis of sepsis of hospitalizes patients

Inflammatory markers in saliva for diagnosis of sepsis of hospitalizes patients

Reasons for Hospitalisation, Sepsis Development and Mortality Among Syrian Patients in an Intensive Care Unit

Yoğun Bakımlarda İnvazif Küf Enfeksiyonları: Epidemiyoloji, Mikrobiyolojik Tanı ve Antifungal Direnç

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