Epidemiology of scrub typhus in a tertiary care hospital of Southern Odisha: a cross sectional study

Panigrahi, Akash; Narasimham, M.V.; Biswal, Manisha; Bisht, Kamlesh; Mishra, Biswakalyan; Parida, Banojini

doi:10.1016/j.ijmmb.2022.09.005

Cited by 3 publications

(4 citation statements)

References 22 publications

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“…The age of the patients varied from 29 days to 84 years. The age group of 1-14 years constituted majority of the cases (58.1%) and the >71-year age group constituted the least with 2 (2.8%) cases [ 26 ]. Various studies have used different diagnostic techniques such as ELISA, PCR, Weil-Felix test, and rapid diagnostic tests to confirm ST cases.…”

Section: Reviewmentioning

confidence: 99%

“… Studies by Vanramliana et al [ 1 ], Narang et al [ 22 ], Pandey et al [ 23 ], Damodar et al [ 25 ], Panigrahi et al [ 26 ], and Devamani et al [ 24 ] …”

Section: Reviewmentioning

confidence: 99%

“…Damodar et al linked scrub typhus to AES in south Indian states [ 25 ]. Panigrahi et al explored acute undifferentiated febrile illness cases, noting 43.5% positivity and higher prevalence among the 1-14 age group [ 26 ]. Devamani et al explored seroprevalence, noting variations across rural-urban and plain regions [ 24 ].…”

Section: Reviewmentioning

confidence: 99%

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Unravelling the Enigma of Scrub Typhus: A Critical Review and Insights Into Epidemiology, Clinical Features, Diagnostic Advances, and Emerging Trends

Tarale,

Sajjanar

2024

Cureus

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Scrub typhus (ST) is caused by the bacterium Orientia tsutsugamushi , which exhibits significant antigenic diversity and is prevalent in the Asia-Pacific region. Its clinical presentation is characterized by non-specific symptoms such as headache, myalgia, sweating, and vomiting, along with the abrupt onset of fever and chills. An eschar is often visible in the axilla, groin, or inguinal area and is present in around half of the confirmed cases. The Weil-Felix test is the earliest detection technique, though it is not highly specific. Diagnostic procedures include biopsy, culture, serology, and PCR. The molecularly detectable amount of Orientiae in the bloodstream occasionally reaches levels that are identified during acute illness and vanish after the first round of appropriate antibiotic treatment. This study offers a thorough review of ST, a disease carried by vectors caused by Orientia tsutsugamushi. We emphasize on the significance of monitoring and awareness campaigns, diagnostic problems, and geographical differences. It is essential to use multidisciplinary techniques combining epidemiologists, public health authorities, and doctors. Sustained observation and research are essential for developing successful preventative and control measures. When participating in outdoor activities in areas known for such infections or at particular times of the year when ticks or mites carry the rickettsia infection, people should take great precautions to prevent getting bitten by ticks or mites. Prompt medical evaluation is advised if suspicious symptoms or signs appear, especially in elderly individuals.

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Section: Reviewmentioning

confidence: 99%

“… Studies by Vanramliana et al [ 1 ], Narang et al [ 22 ], Pandey et al [ 23 ], Damodar et al [ 25 ], Panigrahi et al [ 26 ], and Devamani et al [ 24 ] …”

Section: Reviewmentioning

confidence: 99%

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Unravelling the Enigma of Scrub Typhus: A Critical Review and Insights Into Epidemiology, Clinical Features, Diagnostic Advances, and Emerging Trends

Tarale,

Sajjanar

2024

Cureus

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“…Scrub typhus is a vector-borne zoonosis caused by the organism Oricntia tsutsugamushi , [ 1 ] and endemic in Asia-Pacific area. [ 2 , 3 ] The most typical symptoms in adults were fever and headache, and fever in pediatric. [ 3 , 4 ] Cardiac manifestations caused by O tsutsugamushi infection including angina, bradycardia, and electrocardiogram (ECG) abnormalities were fewer reported recently.…”

Section: Introductionmentioning

confidence: 99%

The first case report of acute myocardial infarction in young adult caused by scrub typhus

Chen,

Guo,

Wang

et al. 2023

Medicine

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Rationale: Scrub typhus is a zoonotic disease caused by Orientia tsutsugamushi, a gram-negative intracellular bacterium and endemic in Asia-Pacific area. Acute myocardial infarction after Oricntia tsutsugamushi infection was rarely reported, and young adult was not reported. Patient conerns: A 33-year-old man came to the emergency complained with chest tightness and fever for 4 days. Diagonoses: After Weil-Felix agglutination test (titer 1:160) twice, scrub typhus was diagnosed. Interventions: After treating with a hormonotherapy, antibiotic and ventilator-assisted ventilation, his chest tightness was mild lessened with normal breath and body temperature. However, an emergent coronary angiography performed unnormal, then a percutaneous coronary intervention was realized with the implantation of a stent. Outcomes: After the surgeon, his chest tightness was totally released, and he was discharged. Lessons: Our case was the first report of young adult acute myocardial infarction after O tsutsugamushi infection and we tried to figure out the potential mechanism and how to deal with.

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Unveiling the burden of scrub typhus in acute febrile illness cases across India: A systematic review & meta-analysis

Sondhiya,

Manjunathachar,

Singh

et al. 2024

IJMR

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Background & objectives Scrub typhus is an emerging mite-borne zoonotic infection that has been overlooked, despite being one of the most widespread severe vector-borne diseases. With an estimated one billion people at risk worldwide and one million annual cases, it poses a significant public health concern. While various studies have investigated the prevalence of scrub typhus in different regions of India, a comprehensive regional systematic review and meta-analysis on the seropositivity of scrub typhus among acute febrile cases has been lacking. To address this gap, we conducted a systematic review and meta-analysis to compile information on the current seroprevalence of scrub typhus in acute febrile illness cases in India. Methods A literature search of multiple databases on prevalence of scrub typhus in acute febrile illness in India, 60 eligible studies out of 573 studies. The prevalence of individual studies was double arcsine transformed, and the pooled prevalence was calculated using inverse variance method. Results In total, these studies encompassed 34,492 febrile cases. The overall seroprevalence of scrub typhus among acute febrile illness cases in India was found to be 26.41 per cent [95% confidence interval (CI): 22.03-31.03]. Additionally, the pooled case fatality rate (based on data from six studies) among scrub typhus-positive cases yielded a case fatality rate of 7.69 per cent (95% CI: 4.37-11.72). Interpretation & conclusions This meta-analysis shows that scrub typhus is a significant health threat in India. Preventive measures to control scrub typhus need to be given priority.

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Epidemiology of scrub typhus in a tertiary care hospital of Southern Odisha: a cross sectional study

Cited by 3 publications

References 22 publications

Unravelling the Enigma of Scrub Typhus: A Critical Review and Insights Into Epidemiology, Clinical Features, Diagnostic Advances, and Emerging Trends

Unravelling the Enigma of Scrub Typhus: A Critical Review and Insights Into Epidemiology, Clinical Features, Diagnostic Advances, and Emerging Trends

The first case report of acute myocardial infarction in young adult caused by scrub typhus

Unveiling the burden of scrub typhus in acute febrile illness cases across India: A systematic review & meta-analysis

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