Epidemiology of sarcoidosis: solving the jigsaw puzzle

Cozier, Yvette C.; Arkema, Elizabeth V.; Rodríguez, J. Villamor; Berman, Jeffrey S.; Govender, Praveen

doi:10.1183/2312508x.10031120

Cited by 2 publications

(2 citation statements)

References 115 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While sarcoidosis can be diagnosed at any age, the apparent peak incidence is in the range of 46 to 51 years . Although a predominance of ( 7 ) involvement in the female sex has been reported, the reason for this is not known . (8) Race influences the prognosis of the disease, being favorable in Caucasians who are most commonly symptomatic and present with erythema nodosum, while African Americans have more severe forms with more frequent extrapulmonary involvement and a more reserved prognosis .…”

Section: Introductionmentioning

confidence: 99%

Persistent Anterior Thoracalgia in a Patient with Mediastinal - Pulmonary Sarcoidosis

Mălăescu,

Mihălţan,

Constantin

2023

Internal Medicine

View full text Add to dashboard Cite

Sarcoidosis is a systemic condition characterized by the formation of non-caseating granulomas in any organ or tissue, with a predominant impact on the lungs and intrathoracic lymph nodes(1). The heterogeneity of the disease is reflected in the broad possibilities of the clinical and paraclinical evolution, which can range from the incidental identification of the disease in an asymptomatic patient to the progressive chronic involvement of the affected organs. Commonly, sarcoidosis initially manifests through nonspecific respiratory symptoms, characterized by dry cough, dyspnea, chest pain, and fatigue(2,3). Generally, it is considered that this condition occurs in individuals with a susceptible genetic background, exposed to certain environmental factors or antigens that remain unknown, despite numerous existing hypotheses(4). Cardiac involvement in sarcoidosis has a significant negative impact on prognosis. Although this location of the disease is predominantly silent, 5% of cases present with dilated or restrictive cardiomyopathy, progressive heart failure, high-grade atrioventricular blocks, and ventricular arrhythmias(5). The authors present the case of a young patient who, although at the onset of the disease, exhibited a typical clinical and imaging profile of sarcoidosis, myocardial involvement - a rare localization of this pathology - was detected during the course of the condition. Patients with sarcoidosis may have normal spirometry, may present with a restrictive syndrome (similar to diffuse interstitial lung diseases), or an obstructive syndrome, secondary to the involvement of small bronchi and bronchial distortions caused by the disease, often with an unfavorable prognosis.

show abstract

Section: Introductionmentioning

confidence: 99%

Persistent Anterior Thoracalgia in a Patient with Mediastinal - Pulmonary Sarcoidosis

Mălăescu,

Mihălţan,

Constantin

2023

Internal Medicine

View full text Add to dashboard Cite

show abstract

“…It is more common in females [ 1 ], and the age at diagnosis is usually between 40 and 55 years [ 1 ]. Sarcoidosis is uncommon in people less than 15 years of age and greater than 70 years of age [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Exertional Dyspnea Incidentally Diagnosed as Sarcoidosis: A Teaching Hospital Experience

Nartey,

Ulzen-Appiah

2023

Case Reports in Pulmonology

View full text Add to dashboard Cite

Background. Sarcoidosis is a complex disease with nonspecific etiology and clinical presentation. Its diagnosis is often delayed due to the absence of a single specific investigation modality. A multidisciplinary approach is necessary for its diagnosis. Report. A 49-year-old male presented with recurrent dyspnea on exertion, easy fatigue, and chest pain after several visits to different health facilities over 5 months. A diagnosis of pulmonary sarcoidosis was made after a series of laboratory and imaging investigations were done revealing bilateral reticonodular opacifications, noncaseating granulomata, elevated serum ACE and calcium levels consistent with sarcoidosis. Conclusion. Sarcoidosis, although a rare presentation in our setting, may easily be overlooked or misdiagnosed if a holistic or multidisciplinary approach is not employed in its diagnosis. Nonspecificity of symptoms contributes to the delayed diagnosis.

show abstract

Epidemiology of sarcoidosis: solving the jigsaw puzzle

Cited by 2 publications

References 115 publications

Persistent Anterior Thoracalgia in a Patient with Mediastinal - Pulmonary Sarcoidosis

Persistent Anterior Thoracalgia in a Patient with Mediastinal - Pulmonary Sarcoidosis

Exertional Dyspnea Incidentally Diagnosed as Sarcoidosis: A Teaching Hospital Experience

Contact Info

Product

Resources

About