Epidemiology of Rotavirus Diarrhea among Children Younger Than 5 Years in Enugu, South East, Nigeria

Tagbo, Beckie Nnenna; Mwenda, Jason M.; Armah, George; Obidike, Egbuna; Okafor, Uche; Oguonu, Tagbo; Ozumba, UC; Eke, Christopher Bismarck; Chukwubuike, C.; Edelu, Benedict O; Ezeonwu, BU; Amadi, Oge; Okeke, Ifeyinwa B; Nnani, Okechukwu R.; Ani, Okechukwu; Ugwuezeonu, Ikechukwu; Benjamin-Pujah, Chioma; Umezinne, N.; Ude, Nelson; Nwodo, Chimezie; Ezeonyebuchi, M. C.; Umesie, Esther; Okafor, Vina; Ogude, N.; Osarogborum, Vivian O.; Ezebilo, S.K.; Goitom, Weldegebriel G.; Abanida, Emmanuel; Elemuwa, Chris; Nwagbo, Douglas

doi:10.1097/inf.0000000000000047

Cited by 39 publications

(66 citation statements)

References 19 publications

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“…Findings from the current study show that majority of cases occurred between the months of December to April which corresponds to the rotavirus diarrhoeal season as previously reported in a Nigerian study [11].…”

Section: Discussionsupporting

confidence: 65%

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Retrospective Evaluation of Intussusception in Under-Five Children in Nigeria

Tagbo¹,

Mwenda²,

Eke³

et al. 2014

WJV

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124(15.6%) and abnormal/absent bowel sound 43 (15.9%). Diagnosis was essentially with the aid of abdominal ultrasonography, 38 (63.3%) while surgery (laparotomy) was the treatment of choice in most cases 48 (80.0%). The case fatality rate was 3 (5.0%). Conclusion: None of the cases studied could be directly linked to rotavirus vaccinations. But seasonal peak incidence coincided with rotavirus diarrhea peak incidence. Efforts should be made to institute post-rotavirus vaccine licensure prospective surveillance study in order to fully determine any relationship between rotavirus vaccination and intussusception in Enugu, South east, Nigeria.

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Section: Discussionsupporting

confidence: 65%

“…Rotavirus is the most common cause of severe dehydrating diarrhoea among infants and young children [11] resulting in about 453,000 mortalities in children <5 years of age annually worldwide (with 232,000 deaths occurring in sub-Saharan Africa) [12] [13].…”

Section: Introductionmentioning

confidence: 99%

Retrospective Evaluation of Intussusception in Under-Five Children in Nigeria

Tagbo¹,

Mwenda²,

Eke³

et al. 2014

WJV

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“…Moreover, it is comparable to the detection rates reported for African countries where RV vaccine is not yet included in the free national childhood programme: 25.2 % in Egypt (Matson et al, 2010), 18 % in Tanzania (Moyo et al, 2007) and 18 % in Nigeria (Aminu et al, 2010). However, the prevalence of RVA infection in the present study is lower than those found in Morocco (42 %) (Benhafid et al, 2013), Cameroon (42.8 %) (Ndze et al, 2012), southern Ghana (48.2 %) (Enweronu-Laryea et al, 2013), south-eastern Nigeria (56 %) (Tagbo et al, 2014) (Sowmyanarayanan et al, 2012). Such differences may be partly due to the inclusion criteria of each study: differences in the period of study (sampling done during the whole year or focused on only during the outbreak period) and differences in the study populations (children <5 years old versus children <2 years old or sometimes patients of all ages; hospitalized children versus outpatients).…”

Section: Rva Detection Ratecontrasting

confidence: 46%

Distribution of rotavirus VP7 and VP4 genotypes circulating in Tunisia from 2009 to 2014: Emergence of the genotype G12

Moussa

Fredj

Fodha

et al. 2016

Journal of Medical Microbiology

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Group A rotavirus (RVA) represents the most important aetiological agent of diarrhoea in children worldwide. From January 2009 to December 2014, a multi-centre study realized through 11 Tunisian cities was undertaken among children aged <5 years consulting or hospitalized for acute gastroenteritis. A total of 1127 faecal samples were collected. All samples were screened by ELISA for the presence of RVA antigen. RVA-positive samples were further analyzed by PAGE and used for G/P-genotyping by semi-nested multiplex RT-PCR. Globally, 270 specimens (24 %) were RVA-positive, with peaks observed annually between November and March. Nine different electropherotypes could be visualized by PAGE, six with a long profile (173 cases) and two with a short one (seven cases). Mixed profiles were detected in two cases. Among the 267 VP7 genotyped strains, the predominant G-genotype was G1 (39.6 %) followed by G3 (22.2 %), G4 (13 %), G9 (11.5 %), G2 (5.2 %) and G12 (5.2 %). Among the 260 VP4 genotyped strains, P[8] genotype was the predominant (74. 9 %). Uncommon G/Pgenotype combinations, mixed infections and untypeable strains were also detected. This is the first report, in Tunisia, of multiple detection of an emerging human RVA strain, G12 genotype. This study highlighted the need for maintaining active surveillance of emerging strains in Northern Africa.

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“…Similar association of type of feed to rotavirus was also reported by John et al, who observed that children on exclusive breast feeds had a reduced prevalence of rotavirus. 22 This was also observed in other studies, where breastfeeding was found to temporarily postpone rather than prevent the outcome. [23][24][25] In contrast, studies from Bangladesh have eported that breast feeding is only a minor contributor to the protection of viral disease.…”

Section: Discussionsupporting

confidence: 69%