Epidemiology of Rheumatoid Arthritis: Rheumatoid Arthritis and Mortality

Myasoedova, Elena; Davis, John M.; Crowson, Cynthia S.; Gabriel, Sherine E.

doi:10.1007/s11926-010-0117-y

Cited by 145 publications

(92 citation statements)

References 44 publications

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“…The most important causes of death among patients with RA are cardiovascular diseases, respiratory diseases, digestive diseases, hematologic diseases, infectious diseases, and malignancies (11). However, the causes of death do not have to correspond with the preexisting comorbid conditions that are longitudinally associated with mortality.…”

Section: Introductionmentioning

confidence: 99%

Association of Somatic Comorbidities and Comorbid Depression With Mortality in Patients With Rheumatoid Arthritis: A 14‐Year Prospective Cohort Study

Hoek

Boshuizen

Roorda

et al. 2016

Arthritis Care & Research

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Objective. Patients with rheumatoid arthritis (RA) have a significantly increased risk of mortality compared with the general population. One of the most important predictors for mortality is somatic comorbidity. Moreover, studies have demonstrated that comorbid depression is associated with mortality. Which specific comorbidities are associated with mortality is less investigated. The purpose of this study was to investigate the association of a wide range of comorbidities with mortality in patients with RA. Methods. Longitudinal data over a 14-year period were collected from 882 patients with RA. Data were assessed with questionnaires. The mortality status was obtained from the Statistics Netherlands for the period 1996-2011 for 99% of the patients. Somatic comorbidity was assessed in 1997, 1998, 1999, and 2008 and measured by a national populationbased questionnaire including 20 chronic diseases. Comorbid depression was assessed in 1997, 1998, and 1999 and measured with the Center for Epidemiologic Studies Depression Scale. Cox regression was used to study the relationship between comorbidity and mortality. Results. At baseline, 72% of the patients were women. The mean 6 SD age was 59.3 6 14.8 years, and the median (interquartile range) disease duration was 5.0 (2.0-14.0) years. A total of 345 patients died during the study period. Comorbidities that were associated with mortality were circulatory conditions (hazard ratio [HR] Conclusion. Comorbid circulatory conditions, respiratory conditions, cancer, and depression are associated with mortality among patients with RA. Careful monitoring of these comorbidities during the course of the disease and adequate referral may improve health outcomes and chances of surviving.

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Section: Introductionmentioning

confidence: 99%

Association of Somatic Comorbidities and Comorbid Depression With Mortality in Patients With Rheumatoid Arthritis: A 14‐Year Prospective Cohort Study

Hoek

Boshuizen

Roorda

et al. 2016

Arthritis Care & Research

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“…Conventional risk factors (abnormal body mass index (BMI), abnormal lipogram, smoking, hypertension, diabetes mellitus, family history of cardiac disease and a personal history of cardiac disease) [8,9], accelerated atherosclerosis due to inflammation [7,10,11], and autonomic dysfunction [12][13][14][15] can all play a role in the etiopathogenesis.…”

Section: Introductionmentioning

confidence: 99%

Effect of exercise on cardiac autonomic function in females with rheumatoid arthritis

et al. 2012

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The objective of this study is to evaluate the effect of exercise on cardiac autonomic function as measured by short-term heart rate variability (HRV) in females suffering from rheumatoid arthritis (RA). Females with confirmed RA were randomly assigned to an exercise group (RAE) and a sedentary group (RAC). RAE was required to train under supervision two to three times per week, for 3 months. Three techniques (time domain, frequency domain and Poincaré plot analyses) were used to measure HRV at baseline and study completion. At baseline, RAC (n018) had a significantly higher variability compared to RAE (n019) for most HRV indicators. At study completion, the variables showing significant changes (p00.01 to 0.05) favoured RAE in all instances. Wilcoxon signed rank tests were performed to assess changes within groups from start to end. RAE showed significant improvement for most of the standing variables, including measurements of combined autonomic influence, e.g. SDRR (p00.002) and variables indicating only vagal influence, e.g. pNN50 (p00.014). RAC mostly deteriorated with emphasis on variables measuring vagal influence (RMSSD, pNN50, SD1 and HF (ms 2 )). Study results indicated that 12 weeks of exercise intervention had a positive effect on cardiac autonomic function as measured by short-term HRV, in females with RA. Several of the standing variables indicated improved vagal influence on the heart rate. Exercise can thus potentially be used as an instrument to improve cardiac health in a patient group known for increased cardiac morbidity.

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“…For CD, the onset of symptoms often occurs in adulthood, despite seroconversion early in life and the presentation in children <3 years of age [51]. For RA, UC and CrD, the peak age of presentation occurs between 30 and 50 years [52,53]. For T1D, cases are often diagnosed in people below 15 years of age, with peak seroconversion at approximately 3 years of age [51].…”

Section: Symposium: Shared Genetics In Aidmentioning

confidence: 99%