Epidemiology of Revision Total Knee Arthroplasty in the United States, 2012 to 2019

SrTiO3 Nanotube-Based “Pneumatic Nanocannon” for On-Demand Delivery of Antibacterial and Sustained Osseointegration Enhancement

“…Nowadays, bone defects caused by accidental injuries, bone tumors, arthritis, and many other bone diseases constitute significant clinical challenges. − The utilization of orthopedic implants has emerged as a promising therapeutic strategy for treating bone defects. , However, the prevalence of clinical failures in orthopedic implant treatments remains a pervasive issue, with bacterial infection and aseptic loosening being the primary complications. − Clinical track reports reveal that within the failed cases of total knee arthroplasty in the United States, about 20.4% are due to bacterial infection and about 23.1% are due to aseptic loosening. , Infection is caused by the colonization of bacteria on the implant surface, fostering the development of biofilms, which are immensely resistant to the treatment of postoperative antibiotics. − Aseptic loosening is associated with poor osseointegration, and the unsatisfactory osteogenic properties lead to unstable integration between the bone and implant. , The majority of failed orthopedic implant treatments necessitate subsequent revision surgeries, imposing significant physiological and financial burdens on patients . Hence, it is imperative to improve the anti-infective and osseointegration properties of orthopedic implants.…”

“…7−9 Clinical track reports reveal that within the failed cases of total knee arthroplasty in the United States, about 20.4% are due to bacterial infection and about 23.1% are due to aseptic loosening. 10,11 Infection is caused by the colonization of bacteria on the implant surface, fostering the development of biofilms, which are immensely resistant to the treatment of postoperative antibiotics. 12−14 Aseptic loosening is associated with poor osseointegration, and the unsatisfactory osteogenic properties lead to unstable integration between the bone and implant.…”

Is Wear Still a Concern in TKA With Contemporary Conventional and Highly Crosslinked Polyethylene Tibial Inserts in the Mid- to Long-Term?

“…(1) According to registries and epidemiological studies, the most common causes of failure leading to revision include infection and inflammatory responses, mechanical loosening, and instability, with the proportion of revisions due to aseptic loosening decreasing in favor of infection. (2)(3)(4)(5) One limitation of registry reports is that they aggregate early and late failures, which typically represent different rates of etiologies for revision. Therefore, as newer registries increase reporting, they likely overrepresent early failures predominately related to higher rates of early prosthetic joint infection (PJI).…”

Objective gait analysis following total knee arthroplasty with a smart implant directs early intervention with manipulation under anesthesia

“…While complication rates remain low and improvement in patient quality of life years (QALYs) remains high, there is still significant room for improvement (Konopka et al 2018). Given the high volume of procedures, revision TKA is growing rapidly with over 70,000 reported annually (Upfill-Brown et al 2022). While patient outcomes are considered good, some studies still report up to 20% of patients are not satisfied with their TKA (Bourne et al 2010;Noble et al 2006).…”