Epidemiology of respiratory symptoms in children with Down syndrome: a nationwide prospective web-based parent-reported study

Verstegen, Ruud H J; Hout, R.W.N.M. van; Vries, Esther de

doi:10.1186/1471-2431-14-103

Cited by 15 publications

(13 citation statements)

References 24 publications

(30 reference statements)

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“…Bacteria such as Streptococcus pneumonia are the major cause of pneumonia in individuals with DS (Verstegen et al 2014 ), while viruses such as influenza virus, respiratory syncytial virus ( RSV ), and parainfluenza virus account for most respiratory infections in DS (Chan et al 2017 ). RSV, a double-stranded RNA (dsRNA) virus, is the primary cause of severe lower respiratory tract infections (LRI) in young children (< 5 years) (Beckhaus & Castro-Rodriguez, 2018 ; Perez-Padilla et al 2010 ).…”

Section: Prevalence Of Infectious Diseases and Associated Hospitalizamentioning

confidence: 99%

Specific Susceptibility to COVID-19 in Adults with Down Syndrome

Illouz

Biragyn²,

Frenkel‐Morgenstern

et al. 2021

Neuromol Med

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The current SARS-CoV-2 outbreak, which causes COVID-19, is particularly devastating for individuals with chronic medical conditions, in particular those with Down Syndrome (DS) who often exhibit a higher prevalence of respiratory tract infections, immune dysregulation and potential complications. The incidence of Alzheimer’s disease (AD) is much higher in DS than in the general population, possibly increasing further the risk of COVID-19 infection and its complications. Here we provide a biological overview with regard to specific susceptibility of individuals with DS to SARS-CoV-2 infection as well as data from a recent survey on the prevalence of COVID-19 among them. We see an urgent need to protect people with DS, especially those with AD, from COVID-19 and future pandemics and focus on developing protective measures, which also include interventions by health systems worldwide for reducing the negative social effects of long-term isolation and increased periods of hospitalization.

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Section: Prevalence Of Infectious Diseases and Associated Hospitalizamentioning

confidence: 99%

Specific Susceptibility to COVID-19 in Adults with Down Syndrome

Illouz

Biragyn²,

Frenkel‐Morgenstern

et al. 2021

Neuromol Med

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“…The study was ethically approved by the METOPP (now METC Brabant; nr M362). The protocol was also used in a separate cohort of Down syndrome children (with some additional overall questions) and, as such, was published in BMC Pediatrics ( 31 ). The parents and children did not receive any incentive for their participation.…”

Section: Methodsmentioning

confidence: 99%

Respiratory Symptoms in Post-infancy Children. A Dutch Pediatric Cohort Study

Vries

Hout²

2020

Front. Pediatr.

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Aim: To study the pattern of respiratory symptoms in children in the general population.Method: We followed a cohort of children for up to 2 years through parents completing weekly online questionnaires in the Child-Is-Ill study (“Kind-en-Ziekmeting” in Dutch); the study was running 2012–2015. Inclusion criteria were “an ordinary child” (according to the parents) and <18 years old at inclusion. We especially encouraged participation of post-infancy children. Age at inclusion, sex, smoking exposure, allergy in the family, and frequent infections in the family were noted. Pearson's correlation, principal component analysis, latent class analysis, latent profile analysis, linear regression, and linear mixed effects regression were used in the statistical analyses.Results: Data were collected on 55,524 childweeks in 755 children (50% girls; median age, 7 years; interquartile range, 4–11 years, 97% ≥2 years at inclusion), with reported symptom(s) in 8,425 childweeks (15%), leading to school absenteeism in 25%, doctor's visits in 12%, and parental sick leave in 8%; symptoms lasting ≥3 weeks were rare (2% of episodes). Linear mixed effects regression showed significant, but only limited, effects of season on the proportion of “symptom(s) reported” per individual child. Only runny nose showed a significant, but very small, age effect. However, the variability between the children was considerable. There were no obvious subgroups of children with specific symptom combinations.Conclusion: In any randomly chosen week, the vast majority of children (85%) in our—mainly—post-infancy cohort derived from the general population did not have any symptom, even in the younger age group, even in winter. The children showed considerable variability; no clear subgroups of symptom patterns could be identified, underlining the difficult position of healthcare providers. These results support our opinion that post-infancy children in the general population should not be evaluated as if they are infants when they have recurrent respiratory symptoms. If they clearly deviate from the above-described most common pattern, it is wise to keep an eye on potential, maybe even rare, serious underlying causes.

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“…DS is characterized by a variety of dysmorphic features and congenital malformation, including CHD. In addition, respiratory infections are still the most important cause of mortality in DS at all ages 10, 11, 12. Also, DS has been recently recognized as a risk factor for RSV LRTI.…”

Section: Introductionmentioning

confidence: 99%

Down syndrome as risk factor for respiratory syncytial virus hospitalization: A prospective multicenter epidemiological study

Sánchez‐Luna

Medrano

Lirio

2016

Influenza Resp Viruses

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BackgroundRespiratory syncytial virus (RSV) infection in childhood, particularly in premature infants, is associated with significant morbidity and mortality.ObjectivesTo compare the hospitalization rates due to RSV infection and severity of disease between infants with and without Down syndrome (DS) born at term and without other associated risk factors for severe RSV infection.Patients/MethodsIn a prospective multicentre epidemiological study, 93 infants were included in the DS cohort and 68 matched by sex and data of birth (±1 week) and were followed up to 1 year of age and during a complete RSV season.ResultsThe hospitalization rate for all acute respiratory infection was significantly higher in the DS cohort than in the non‐DS cohort (44.1% vs 7.7%, P<.0001). Hospitalizations due to RSV were significantly more frequent in the DH cohort than in the non‐DS cohort (9.7% vs 1.5%, P=.03). RSV prophylaxis was recorded in 33 (35.5%) infants with DS. The rate of hospitalization according to presence or absence of RSV immunoprophylaxis was 3.0% vs 15%, respectively.ConclusionsInfants with DS showed a higher rate of hospitalization due to acute lower respiratory tract infection and RSV infection compared to non‐DS infants. Including DS infants in recommendations for immunoprophylaxis of RSV disease should be considered.

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Epidemiology of respiratory symptoms in children with Down syndrome: a nationwide prospective web-based parent-reported study

Cited by 15 publications

References 24 publications

Specific Susceptibility to COVID-19 in Adults with Down Syndrome

Specific Susceptibility to COVID-19 in Adults with Down Syndrome

Respiratory Symptoms in Post-infancy Children. A Dutch Pediatric Cohort Study

Down syndrome as risk factor for respiratory syncytial virus hospitalization: A prospective multicenter epidemiological study

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