Epidemiology of Pulmonary Aspergillosis in Hospitalized Patients in Poland During 2009–2016

Tarka, Patryk; Nitsch–Osuch, Aneta; Goryński, Paweł; Tyszko, Piotr; Bogdan, Magdalena; Kanecki, Krzysztof

doi:10.1007/5584_2019_347

Cited by 11 publications

(11 citation statements)

References 36 publications

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“…Healthcare practitioners should play a major role in the process of the patient's adjusting not only to chronic diseases or disability, but also to rare diseases [28,29]. In the opinion of the authors of the current study, it is rather disturbing that they did not find any correlation between satisfaction with medical care in the disease process, and the respondents' displaying constructive adjustment reactions.…”

Section: Discussioncontrasting

confidence: 60%

Adjustment in women treated for rheumatoid arthritis

Janiszewska¹,

Drop²,

Drop³

et al. 2021

Ann Agric Environ Med.

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Introduction. The favourable or unfavourable process of a patient's adaptation to a challenging medical condition may indicate that certain adjustment reactions, which can be either constructive or undesirable, tend to prevail. Objective. The aim of the study was to examine the adjustment reactions of patients, and to define the correlation between the reactions and socio-demographic factors, health self-assessment, satisfaction with medical care, duration of treatment, and limitations in women treated for rheumatoid arthritis. Materials and method. The study was conducted at the Department of Rheumatology and Connective Tissue Diseases and the Specialist Outpatient Clinic of the Independent Public Teaching Hospital No. 4 in Lublin, Poland. The Polish adaptation of the Reactions to Impairment and Disability Inventory RIDI (H. Livneh, R. Antonak, 1990) was used in the study, together with an Original Questionnaire. A p-value of <0.05 was set to define statistical differences. Analysis was performed using commercial SPSS Statistics software (IBM Corp., Armonk, NY). Results. Adjustment reactions, adaptive reactions, i.e. adjustment (3±0.5) and acknowledgement (2.6±0.4) were found to markedly prevail, while the lowest mean value was observed for denial (1.9±0.4), which was considered a negative reaction. Longer duration of the disease was associated with a lower level of external hostility. Low health self-assessment and significant limitations impairing everyday activities, caused by pain, deformity and impaired joint mobility, were mostly related to unfavourable early and intermediate non-adaptive reactions. Conclusions. Knowledge of the adjustment reactions and their moderating factors appears to be crucial in the planning of measures aimed at the rehabilitation of RA patients.

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Section: Discussioncontrasting

confidence: 60%

Adjustment in women treated for rheumatoid arthritis

Janiszewska¹,

Drop²,

Drop³

et al. 2021

Ann Agric Environ Med.

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“…1 The incidence of fungal infection has shown an upward trend. [2][3][4][5] Although significant improvements have been made in disease management and treatment of fungal infections, the mortality rate has only increased. 6 Early diagnosis of invasive fungal infection (IFI) is a difficult in routine clinical practice but key for the initiation of targeted therapies.…”

Section: Introductionmentioning

confidence: 99%

<p>Emerging Invasive Fungal Infections: Clinical Features and Controversies in Diagnosis and Treatment Processes</p>

Zhang¹,

Zhu²

2020

IDR

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Background: The diagnosis and treatment of invasive fungal infection (IFI) are still challenging due to its complexity and non-specificity. This study was aimed to investigate the clinical features, diagnosis process, and outcomes of patients with emerging IFIs. Methods: A retrospective review of emerging IFIs in adult patients at a university hospital in China was conducted; diagnoses were based on the criteria of EORTC/MSG 2008. Results: 145 IFI patients (pulmonary, intestinal and urinary) were enrolled in this study, including 80 proven (55.2%), 59 probable (40.7%), or 6 possible IFIs (4.1%). Among the 126 pulmonary IFIs, the positivity rate for sputum microscopy, sputum culture, and 1.3-ß-D-glucan (BG) test was 54.0%, 44.4%, and 37.3%, respectively. Among the 19 intestinal and urinary IFIs, routine examination of stool or urine and their culture were the main methods of detection. Positive results of 75 detected fungal strains from the samples showed that 30 cases were complicated with one or more bacterial infections. The average length of hospital stay of IFI patients was 14.0 (10.0, 20.0) days. The time from admission to antifungal therapy initiation (P<0.001), liver cirrhosis (P<0.001), hematological tumor (P<0.001), coinfection (P=0.019) and immune diseases (P=0.025) were independent predictors of prolonged hospitalization. Conclusion: Delayed time was the primary predictor of prolonged hospitalization. This prediction is suggested to improve IFI diagnostic and therapeutic process of IFI to promote prognosis.

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“…Infections related to Aspergillus species have become a major focus of clinical microbiology and infectious disease as the number of patients infected with Aspergillus species rose dramatically in recent years 1,2 . In immunocompetent hosts, Aspergillus species rarely cause serious illnesses, except for aspergilloma in patients with pre‐existing chronic lung diseases and a few related chronic pulmonary diseases, such as chronic cavitary pulmonary aspergillosis, chronic fibrosing aspergillosis and subacute invasive aspergillosis (previously chronic necrotising aspergillosis) 3 .…”

Section: Introductionmentioning

confidence: 99%

Rare/cryptic Aspergillus species infections and importance of antifungal susceptibility testing

Tsang

Tang

Yé

et al. 2020

Mycoses

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Summary Background The number of patients infected with Aspergillus rose dramatically in recent years. However, studies on the clinical spectrum and antifungal susceptibilities of non‐classical (non‐fumigatus, non‐flavus, non‐niger and non‐terreus) pathogenic Aspergillus species are very limited. Objectives We examined the clinical spectrum and antifungal susceptibilities of 34 non‐duplicated, non‐classical Aspergillus isolates collected from Hong Kong, Shenzhen and Shanghai. Methods The Aspergillus isolates were identified by internal transcribed spacer, partial BenA and partial CaM sequencing and phylogenetic analyses. Susceptibility testing against eight antifungals was performed following the European Committee for Antimicrobial Susceptibility Testing's methodology. Results The 34 Aspergillus isolates were identified as 14 different rare/cryptic species of four sections (Flavi [n = 8], Nidulantes [n = 8], Nigri [n = 17] and Restricti [n = 1]). Except for one patient whose clinical history could not be retrieved, 72.7% of the remaining patients had underlying conditions predisposing them to Aspergillus infections. The most common diseases were pulmonary infections (n = 15), followed by skin/nail infections (n = 6), chronic otitis externa and/or media (n = 5), wound infections (n = 2) and mastoiditis/radionecrosis (n = 1), while three were colonisations. Five patients succumbed due to the infections during the admission, and another two died 5 years later because of chronic pulmonary aspergillosis. Antifungal susceptibility testing showed that they possessed different susceptibility profiles compared to the classical Aspergillus species. The majority of isolates characterised were sensitive or wild‐type to amphotericin B. The minimum effective concentrations for all the three echinocandins were also low. Conclusion Susceptibility testing should be performed for infections due to these rare/cryptic Aspergillus species to guide proper patient management.

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Epidemiology of Pulmonary Aspergillosis in Hospitalized Patients in Poland During 2009–2016

Cited by 11 publications

References 36 publications

Adjustment in women treated for rheumatoid arthritis

Adjustment in women treated for rheumatoid arthritis

<p>Emerging Invasive Fungal Infections: Clinical Features and Controversies in Diagnosis and Treatment Processes</p>

Rare/cryptic Aspergillus species infections and importance of antifungal susceptibility testing

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