Epidemiology of psychosis in Parkinson's disease

Fénelon, Gilles; Alves, Guido

doi:10.1016/j.jns.2009.08.014

Cited by 268 publications

(239 citation statements)

References 67 publications

(110 reference statements)

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“…However, in spite of several studies no strong link has been identified between the occurrence of VH and the dosage or duration of dopaminergic medication [1,4,5].…”

Section: Introductionmentioning

confidence: 98%

“…Visual hallucinations (VH) occur commonly in Parkinson's disease (PD) with an estimated prevalence of 22-38%, increasing up to more than 60% after long-term follow-up [1,2]. The most significant risk factors in the development of VH include disease duration, motor symptom severity and cognitive impairment.…”

Section: Introductionmentioning

confidence: 99%

“…They become increasingly intrusive in many patients and are believed to be predictive for PD dementia [1].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Parkinson's disease, visual hallucinations and apomorphine: A review of the available evidence

Borgemeester

Lees²,

Laar

2016

Parkinsonism & Related Disorders

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“…However, in spite of several studies no strong link has been identified between the occurrence of VH and the dosage or duration of dopaminergic medication [1,4,5].…”

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Parkinson's disease, visual hallucinations and apomorphine: A review of the available evidence

Borgemeester

Lees²,

Laar

2016

Parkinsonism & Related Disorders

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“…Psychosis, characterized by the presence of hallucinations and delusions, has been studied in the general PD population, 6 with published prevalence rates ranging from 17% to 72%. 6 The wide variation in reported prevalence may be in part due to methodological differences in the use of various scales and questionnaires, such as the Unified Parkinson's Disease Rating Scale (UPDRS) or the Neuropsychiatric Inventory, to screen for specific symptoms of psychosis.…”

mentioning

confidence: 99%

Postoperative symptoms of psychosis after deep brain stimulation in patients with Parkinson’s disease

Qureshi

Cheng

Sunshine

et al. 2015

FOC

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OBJECT Cases of postoperative psychosis in Parkinson’s disease patients receiving deep brain stimulation (DBS) treatment have previously been published. However, the magnitude of symptom incidence and the clinical risk factors are currently unknown. This retrospective study sheds light on these issues by investigating psychosis in a group of 128 Parkinson’s disease patients who received DBS implants. METHODS A retrospective chart review was performed to obtain surgery dates, follow-up clinic visit dates, and associated stimulation parameter settings (contacts in use and the polarity of each along with stimulation voltage, frequency, and pulse width) for each patient. Unified Parkinson’s Disease Rating Scale II Thought Disorder scores, used as a clinical assessment tool to evaluate the presence of psychosis at each visit, were also collected. The data were compiled into a database and analyzed. RESULTS The lifetime incidence of psychosis in this cohort of patients was 28.1%. The data suggest that risk of psychosis remains fairly constant throughout the first 5 years after implantation of a DBS system and that patients older at the time of receiving the first DBS implant are not only more likely to develop psychosis, but also to develop symptoms sooner than their younger counterparts. Further analysis provides evidence that psychosis is largely independent of the clinically used electrode contact and of stimulation parameters prior to psychosis onset. CONCLUSIONS Although symptoms of psychosis are widely seen in patients with Parkinson’s disease in the years following stimulator placement, results of the present suggest that most psychoses occurring postoperatively are likely independent of implantation and stimulation settings.

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“…The pharmacological therapy of Parkinson's Disease (PD) is commonly associated with side effects, such as compulsive behavior, dyskinesias, motor fluctuations and hallucinations, which can have a significant impact on the quality of life of the patient [1]. The magnitude of these side effects depends on the duration of treatment, duration of the disease, type of drug, and combination of drugs used [2].…”

Section: Introductionmentioning

confidence: 99%

Medication Side Effect Profiles in PD Patients in a Safety-Net Hospital

Sisniega¹,

Madhusudhan²,

Rahmani³

et al. 2017

APD

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Background: Compulsive behavior, dyskinesias, motor fluctuations, and hallucinations are common Parkinson's disease (PD) medication side effects.These are yet to be examined in relation to race and level of education. The goal of this analysis was to identify socioeconomic or clinical variables that are associated with compulsive behavior, dyskinesias, motor fluctuations, and hallucinations in patients in a safety-net hospital. Methods: A movement disorder patient database containing 452 patients with idiopathic PD was analyzed for differences in PD medication side effects using univariate and multivariate logistic regression analysis. Race, sex, and level of education were evaluated as possible confounders. Results: A greater proportion of the patients in this study were Caucasian males. The only variable associated with compulsive behavior was age, with higher age having a protective effect (p = 0.0336). Disease duration (defined as time since the onset of symptoms), diagnosis duration (time since formal diagnosis), and level of education were significantly associated with dyskinesia inunivariate analysis (p =< 0.0001, <0.0001, 0.1236 respectively). However, diagnosis duration was the only variable significantly associated with dyskinesia in multivariate analysis (p = 0.0038), in addition to a borderline significant association when comparing individuals with graduate degree to those who had completed high school education or less (p = 0.0599), with a protective effect of higher education. Disease duration, diagnosis duration, and use of monoamineoxidase inhibitors were also significantly associated with motor fluctuations in the univariate analysis, while only diagnosis duration was significantly associated with motor fluctuations in multivariate analysis (p = 0.0035) with longer diagnosis duration associated with higher risk of motor fluctuations. Age, disease duration, and diagnosis duration were associated with an increased risk of hallucinations

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Epidemiology of psychosis in Parkinson's disease

Cited by 268 publications

References 67 publications

Parkinson's disease, visual hallucinations and apomorphine: A review of the available evidence

Parkinson's disease, visual hallucinations and apomorphine: A review of the available evidence

Postoperative symptoms of psychosis after deep brain stimulation in patients with Parkinson’s disease

Medication Side Effect Profiles in PD Patients in a Safety-Net Hospital

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