Epidemiology of Prurigo Nodularis compared with Psoriasis in Germany: A Claims Database Analysis

Ständer, Sonja; Ketz, Miriam; Kossack, Nils; Akumo, Divine; Pignot, M; Gabriel, Sylvie; Chavda, Rajeev

doi:10.2340/00015555-3655

Cited by 38 publications

(54 citation statements)

References 24 publications

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“…A recent European study from a German population found a prevalence of 0.1%. Similar to US studies, PN patients tended to be older with a median age at diagnosis of 58.28 years [14] .…”

Section: Epidemiologysupporting

confidence: 75%

IFSI-guideline on chronic prurigo including prurigo nodularis

Ständer

Pereira

Berger

et al. 2020

Itch

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Chronic prurigo (CPG) is a highly burdensome pruritic disease characterized by chronic itch, a prolonged scratching behavior and the development of localized or generalized hyperkeratotic pruriginous lesions. Neuronal sensitization and the development of an itch-scratch cycle contribute to the augmentation of pruritus and the chronicity of the disease. We provide here the first international guideline for a rational diagnostic and therapeutic approach for CPG. Recommendations are based on available evidence and expert opinion. The diagnosis of CPG is made clinically. A detailed medical history together with laboratory and radiological examinations are advised in order to determine the severity of CPG, identify the underlying origin of the itch and assist in the elaboration of a treatment plan. Therapeutically, it is advised to adopt a multimodal approach, including general strategies to control itch, treatment of the underlying pruritic conditions, and of the pruriginous lesions. Topical (corticosteroids, calcineurin inhibitors, capsaicin) and systemic antipruritic agents (eg, gabapentinoids, immunosuppressants, and opioid modulators) as well

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“…A recent European study from a German population found a prevalence of 0.1%. Similar to US studies, PN patients tended to be older with a median age at diagnosis of 58.28 years [14] .…”

Section: Epidemiologysupporting

confidence: 75%

IFSI-guideline on chronic prurigo including prurigo nodularis

Ständer

Pereira

Berger

et al. 2020

Itch

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“…All patient-level data in the database is anonymized and only aggregated data (n≥5) is reported according to German data protection regulations, with no independent ethics committee approval needed. The database provides a representative sample (in terms of age, gender, and morbidity) of the German population and was benchmarked against the total German SHI population [ 13 ]. We used data from January 1 st , 2011 to December 31 st , 2019 (including baseline and follow-up periods) for analyses.…”

Section: Methodsmentioning

confidence: 99%

Pneumococcal vaccination rates in immunocompromised patients in Germany: A retrospective cohort study to assess sequential vaccination rates and changes over time

Sprenger

Häckl

Kossack³

et al. 2022

PLoS ONE

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Background Pneumococcal vaccination is recommended by the German Standing Committee on Vaccination (STIKO) for infants, elderly 60+ years and patients at risk. In 2016, a sequential pneumococcal vaccination schedule (conjugate vaccine followed by polysaccharide vaccine 6–12 months later) supplemented this recommendation for immunocompromised patients ≥2 years of age. Previous research showed low pneumococcal vaccination rates (pnc-VR) in this vulnerable group. Moreover, no evidence is available on adherence to the newer sequential schedule. This study aimed to analyze the development of pnc-VRs in immunocompromised patients and rates of sequential vaccinations according to the STIKO recommendations. Methods Using a representative health claims database, we assigned incident immunocompromised patients ≥2 years of age to one of two successive cohorts to observe trends over time: cohort A (first diagnosis of immunocompromised condition between 01/2013 and 12/2014), and cohort B (first diagnosis between 01/ 2015 and 12/2017). Pnc-VR within two years after first diagnosis and cumulative pnc-VR was compared among both cohorts. In cohort B, we assessed sequential pnc-VR within 15 months of the first vaccination. For additional analyses, patients were stratified by age, gender and immunocompromising condition. Results Cohort A and B comprised 193,521 and 289,279 patients, respectively. Overall pnc-VR increased over time from 4.3% (cohort A; 95%-confidence interval: 4.3%-4.4%) to 6.0% (cohort B; 5.9%-6.1%), with highest pnc-VRs in men ≥60 years (11.3%: 11.1%-11.6%) and HIV patients (15.2%: 13.1%-17.4%). Cumulative pnc-VRs in cohort B were higher in any quarter following diagnosis when compared with cohort A. Overall sequential pnc-VR in cohort B was 4.0% (3.7%-4.3%), with a higher rate observed in patients aged 16–59 (6.8%: 6.0%-7.7%) vs. patients aged ≥60 years (3.1%: 2.8%-3.4%). Conclusion While some improvements were seen over time, pnc-VRs remain very low in immunocompromised patients, as did sequential vaccination rates. Current recommendations to protect immunocompromised patients from pneumococcal infections are not being sufficiently implemented.

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“…PN patients often carry a significant disease burden with a higher risk of psychiatric disorders (anxiety, mood disorder) and systemic illnesses (chronic kidney disease) compared to the general population as well as those with other inflammatory skin diseases [ 11 , 12 , 13 , 14 ]. Of note, the association between HIV infection and PN was stronger in African Americans compared to a Caucasian cohort [ 11 ], which emphasizes the possible racial difference in PN co-morbidities.…”

Section: Introductionmentioning

confidence: 99%

Epidemiology, Comorbidities, and Prescription Patterns of Korean Prurigo Nodularis Patients: A Multi-Institution Study

Woo

Wang

Sohn

et al. 2021

JCM

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Prurigo nodularis (PN) is a chronic dermatosis typified by extraordinarily itchy nodules. However, little is known of the nature and extent of PN in Asian people. This study aimed to describe the epidemiology, comorbidities, and prescription pattern of PN in Koreans based on a large dermatology outpatient cohort. Patients with PN were identified from the Catholic Medical Center (CMC) clinical data warehouse. Anonymized data on age, sex, diagnostic codes, prescriptions, visitation dates, and other relevant parameters were collected. Pearson correlation analysis was used to calculate the correlation between PN prevalence and patient age. Conditional logistic regression modeling was adopted to measure the comorbidity risk of PN. A total of 3591 patients with PN were identified at the Catholic Medical Center Health System dermatology outpatient clinic in the period 2007–2020. A comparison of the study patients with age- and sex-matched controls (dermatology outpatients without PN) indicated that PN was associated with various comorbidities including chronic kidney disease (adjusted odds ratio (aOR), 1.48; 95% confidence interval (CI), 1.29–1.70), dyslipidemia (aOR, 1.88; 95% CI, 1.56–2.27), type 2 diabetes mellitus (aOR, 1.37; 95% CI, 1.22–1.54), arterial hypertension (aOR, 1.50; 95% CI, 1.30–1.73), autoimmune thyroiditis (aOR, 2.43; 95% CI, 1.42–4.16), non-Hodgkin’s lymphoma (aOR, 1.95; 95% CI, 1.23–3.07), and atopic dermatitis (aOR, 2.16, 95% CI, 1.91–2.45). Regarding prescription patterns, topical steroids were most favored, followed by topical calcineurin inhibitors; oral antihistamines were the most preferred systemic agent for PN. PN is a relatively rare but significant disease among Korean dermatology outpatients with a high comorbidity burden compared to dermatology outpatients without PN. There is great need for breakthroughs in PN treatment.

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Epidemiology of Prurigo Nodularis compared with Psoriasis in Germany: A Claims Database Analysis

Cited by 38 publications

References 24 publications

IFSI-guideline on chronic prurigo including prurigo nodularis

IFSI-guideline on chronic prurigo including prurigo nodularis

Pneumococcal vaccination rates in immunocompromised patients in Germany: A retrospective cohort study to assess sequential vaccination rates and changes over time

Epidemiology, Comorbidities, and Prescription Patterns of Korean Prurigo Nodularis Patients: A Multi-Institution Study

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