Epidemiology of primary Sjögren's syndrome in north-west Greece, 1982–2003

Alamanos, Yannis; Tsifetaki, Niki; Voulgari, Paraskevi V.; Venetsanopoulou, Aliki; Siozos, Christos; Drosos, Alexandros A.

doi:10.1093/rheumatology/kei107

Cited by 200 publications

(110 citation statements)

References 23 publications

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“…In this setting, it is conceivable that patients with primary SS may also have an increased CV risk. However, the incidence of CV diseases (CVDs) and their impact on survival in primary SS remain unclear, although some studies on large cohorts have found that CVDs are one of the leading causes of mortality in these patients (7,8). Similarly, the presence of subclinical atherosclerosis in primary SS has been scarcely investigated in comparison with RA and SLE (9 -15).…”

Section: Introductionmentioning

confidence: 99%

Prevalence of and Factors Associated With Increased Arterial Stiffness in Patients With Primary Sjögren's Syndrome

Sabio

Sánchez-Berná

Martínez-Bordonado

et al. 2015

Arthritis Care & Research

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Objective. To compare the presence of subclinical atherosclerosis measured by means of pulse wave velocity (PWV) in women with primary Sjögren's syndrome (SS) versus a healthy age-and sex-matched control group, and to identify factors independently associated with PWV in primary SS. Methods. Forty-four women with primary SS and 78 age-matched healthy women without overt cardiovascular (CV) diseases were assessed for traditional and nontraditional CV risk factors. PWV was also performed. A linear regression analysis was used to identify factors independently associated with PWV in primary SS. Results. Women with primary SS had significantly higher PWV than controls (P ‫؍‬ 0.030), and the frequency of increased PWV was significantly higher in this group (25% versus 8%; P ‫؍‬ 0.013). The proportion of patients ages <50 years (ratio 4.6) with increased PWV was almost 2-fold higher than those ages >50 years (ratio 2.4) with respect to controls. Positivity for anti-SSB was more frequent in patients with normal PWV than in those with increased PWV (61% versus 18%; P ‫؍‬

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Section: Introductionmentioning

confidence: 99%

Prevalence of and Factors Associated With Increased Arterial Stiffness in Patients With Primary Sjögren's Syndrome

Sabio

Sánchez-Berná

Martínez-Bordonado

et al. 2015

Arthritis Care & Research

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“…[1][2][3] A study of 467 patients by Garceau and Chalmers from 1963 demonstrated that only 30-40% of them survived 12 months after the diagnosis of oesophageal varices. 1 The most common mode of death was gastrointestinal haemorrhage (34%). Similarly, in 1981, Graham and Smith found a 6-week mortality in 42% of patients with variceal bleeding confirmed by endoscopy, …”

Section: Introductionmentioning

confidence: 99%

Focus on systemic lupus erythematosus in Indigenous Australians: towards a better understanding of autoimmune diseases

Vincent

Bourke

Morand

et al. 2013

Internal Medicine Journal

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The incidence and prevalence of autoimmune diseases such as rheumatoid arthritis, primary Sjögren syndrome, scleroderma and systemic lupus erythematosus (SLE) varies with geography and ethnicity. For example, SLE is reported to be more common in populations such as African‐Caribbeans and Indigenous Australians (IA). As well as socio‐economic status, variation in severity of disease may also show ethnic variability. The initial presentation of SLE in IA, in the context of a unique genetic background and distinctive environmental influences, is often florid with a recurring spectrum of clinical phenotypes. These clinical observations suggest a unique pathway for autoimmunity pathogenesis in this population. For instance, the high prevalence of bacterial infections in IA, particularly group A streptococcus, may be a potential explanation not only for increased incidence and prevalence of SLE but also the commonly florid acute disease presentation and propensity for rapidly progressive end organ threatening disease. This article will review the state of research in autoimmune disease of IA, consider key findings related to autoimmune disease in this population and propose a model potentially to explain the involvement of innate immunity and chronic infection in autoimmune disease pathogenesis. Ultimately, understanding of SLE at this level could affect management and result in personalised and targeted therapies to improve the health status of IA as well as better understanding of SLE pathogenesis per se.

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“…18 According to the classification criteria of the American-European Consensus Group, 19 the prevalence of pSS is far lower than previously assumed, and the reported male/female ratio of 1:9 seems to lie more in the range of 1:20. 20 Use of the American-European Consensus Group criteria will probably result in the participation of fewer males, as well as younger patients in general, and more severely ill patients in future cohort investigations. 21 Information regarding age at disease onset has changed over the last decade, as recent studies are indicating an onset age of approximately 45 years, compared to 56 in earlier studies.…”

Section: Methodsmentioning

confidence: 99%

Prevalence of Extraglandular Manifestations in Patients With Primary Sjögren’s Syndrome in Southern Norway: A Comparison to the Literature

Jorkjend

Johansson

2015

Arch Rheumatol

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Objectives: This study aims to investigate the prevalence of extraglandular manifestations (EGM) in a group of Norwegian patients suffering from primary Sjögren's syndrome (pSS) and compare these findings with the literature. Material and methods: Fifty-three female patients (mean age 60±11.6 years; range 33 to 85 years) fulfilling the clinical criteria for pSS were included in the study. To investigate the prevalence of EGM, a PubMed search from April 1976 to August 2012 identified 100 relevant publications by 88 authors, comprising a total of 14,861 pSS patients. An attempt was made to compare the obtained results regarding the prevalence of EGM with our results. Results: In our study group, mean prevalence rate of EGM was 42.1% with a range from 0 to 92.5% compared to the range of 0.8 to 94% in the PubMed reports on EGM. Epidemiological studies involving large groups of patients tend to yield lower prevalence of EGM than studies based on a smaller sample size. We were unable to compare the reports of prevalence of EGM in patients with pSS due to different methodologies and classification criteria applied in the different studies. Conclusion:The prevalence of pSS in this study was within the range of that reported in the literature. Due to methodological issues, we were unable to compare reports of prevalence of EGM in pSS. Our findings suggest that studies including larger sample sizes may be subjected to underreporting.

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Epidemiology of primary Sjögren's syndrome in north-west Greece, 1982–2003

Cited by 200 publications

References 23 publications

Prevalence of and Factors Associated With Increased Arterial Stiffness in Patients With Primary Sjögren's Syndrome

Prevalence of and Factors Associated With Increased Arterial Stiffness in Patients With Primary Sjögren's Syndrome

Focus on systemic lupus erythematosus in Indigenous Australians: towards a better understanding of autoimmune diseases

Prevalence of Extraglandular Manifestations in Patients With Primary Sjögren’s Syndrome in Southern Norway: A Comparison to the Literature

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