Epidemiology of primary nephrotic syndrome in Egyptian children

Kaddah, A. M.; Sabry, Samar; Emil, Emad; Refaey, Mona El

doi:10.5301/jn.5000051

Cited by 20 publications

(12 citation statements)

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“…Kaddah et al in Cairo, Egypt showed that 34% of their patients had SRNS, which was explained by high consanguinity according to the authors' explanation. 8 In addition to this Kaddah et al study revealed higher rate of MesPGN than ours. Lower steroid resistance was encountered in Yemen (7.1%).…”

Section: Discussionsupporting

confidence: 55%

“…7 Idiopathic nephrotic syndrome shows differences in its steroid response pattern and histopathological spectrum in the various geographical regions. [8][9][10][11][12][13][14][15][16] Therefore, this work was designed to study the clinical profile, steroid response pattern and the underlying histopathological spectrum in children with INS at our locality in Upper Egypt. Sohag City is about 500 Km South to Cairo city and Sohag University Hospital is a referral hospital serves patients from all Upper Egypt Governorates.…”

Section: Introductionmentioning

confidence: 99%

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Patterns of idiopathic nephrotic syndrome in Upper Egyptian children

abdelreheam

Ahmed

Fadda

et al. 2017

Sohag Medical Journal

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Background and aim of work: Idiopathic nephrotic syndrome (INS) is a common and important chronic kidney disease in childhood. Steroid response pattern and the underlying histopathological spectrum of INS show variabilities in the different geographical regions. This work aimed to highlight the clinical profile, steroid response pattern and histopathological spectrum of INS in our locality in Sohag, Upper Egypt. Patients and Methods: A prospective study included 77 children with INS aged from 1-15 years followed for at least one year, diagnosed and treated at our pediatric nephrology unit in the period from January 2010 to December 2014 was done. The patients' demographic features, clinical profile, steroid response pattern and the underlying histopathological spectrum were studied. Results: Total included patients were 77 children. The mean age at disease onset was 4.87±2.94 (range 1.5-15) years. Male/female ratio was 1.6/1. Steroid was given to all patients, 79.2% of patients had steroid sensitive nephrotic syndrome (SSNS), while 20.8% had steroid resistant nephrotic syndrome (SRNS). Out of 61 steroid sensitive patients, about 54% developed either steroid dependent nephrotic syndrome (SDNS) or frequently relapsing nephrotic syndrome (FRNS). Biopsy was done in 33.8% of patients and revealed focal segmental glomerulosclerosis (FSGS) in 42%, minimal change disease (MCD) in 39% and mesangio-proliferative glomerulonephritis (MesPGN) in 19% of patients. End stage renal disease (ESRD) developed in 1 patient with SRNS and FSGS. Conclusion: About eighty percent of our patients were steroid sensitive but more than half of them had SDNS or FRNS. The main histopathological pattern seen in renal biopsies was FSGS.

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Section: Discussionsupporting

confidence: 55%

Section: Introductionmentioning

confidence: 99%

Patterns of idiopathic nephrotic syndrome in Upper Egyptian children

abdelreheam

Ahmed

Fadda

et al. 2017

Sohag Medical Journal

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“…Most patients have multiple relapses, with the risk of steroid toxicity, systemic infections and other complications. Data on acute patterns of diseases such as NS are scarce in Africa (2)(3)(4)(5)(6). Unfortunately, the overall incidence of NS is difficult to estimate in Africa, because most countries lack paediatric nephrologists, vital hospital statistics and national renal disease registries (2).…”

Section: Introductionmentioning

confidence: 99%

“…Unfortunately, the overall incidence of NS is difficult to estimate in Africa, because most countries lack paediatric nephrologists, vital hospital statistics and national renal disease registries (2). Data on acute patterns of diseases such as NS are scarce in Africa (2)(3)(4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

The challenges of caring for children with nephrotic syndrome in a tertiary institution in the Democratic Republic of Congo

et al. 2014

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“…The childhood NS has a male predominance (74%). The mean age of disease onset was 4.43 ± 2.7 years, with patients having onset of ≤ 6 years constituting 81% of patients [2]. Idiopathic nephrotic syndrome (INS) is the most popular form of childhood NS, representing more than 90% of cases between 1 to 10 years of age and 50% after 10 years of age [3].…”

Section: Introductionmentioning

confidence: 99%