Epidemiology of Primary Glomerular Disease in the Elderly

Simon, Pierre; Charasse, Christophe; Autuly, Valérie; Ang, K.S.; Cam, G.; Ramée, M. P.

doi:10.1159/000422489

Cited by 4 publications

(2 citation statements)

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“…36 The clinical manifestations associated with glomerular diseases in elderly patients are similar to those found in younger ones and include acute or chronic renal failure, proteinuria and an abnormal urinary sediment (haematuria usually with dysmorphic red cells and/or red cell casts). The histological findings in the various glomerulopathies are similar to those of younger adults with the exception of the increased incidence of associated arterial sclerosis and arteriolonephrosclerosis.…”

Section: Glomerular Diseasesmentioning

confidence: 98%

Renal disease in elderly patients

Porush

Faubert

1997

Rev. Clin. Gerontol.

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Like other organs in the body, the kidneys undergo age-associated anatomical, structural and physiological changes. Starting at 50 years of age, there is a 3-10% decline in kidney weight for each subsequent decade of life, with the loss of cortical mass greater than medullary mass. In fact, the number of glomeruli start to decrease progressively after age 40, and the number of sclerotic glomeruli increases, making the distinction between involutional and disease-related sclerosis unclear in some cases. The outer cortical glomeruli are, in general, more extensively involved than deeper glomeruli, but glomerular size does not change. In general, the loss of the glomerular mass is proportional to the loss of tubular mass, maintaining glomerulotubular balance. In addition to glomerular sclerosis, there is a gradual increase in interstitial fibrosis, and there is focal thickening of both glomerular and tubular basement membranes, probably due to the accumulation of type IV collagen.

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Section: Glomerular Diseasesmentioning

confidence: 98%

Renal disease in elderly patients

Porush

Faubert

1997

Rev. Clin. Gerontol.

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“…Published estimates of the population rate of kidney biopsies have ranged from 3.3 per 100,000 people per year in Italy (1993) to as high as 16.2 per 100,000 people per year in France (1992-1994) and 21.5 per 100,000 people per year in Australia (1995-1997). [7][8][9] Average age at the time of kidney biopsy was younger in patients from the Nanjing case series (aged 33-37 years) than in case series from the United States, Japan, and Spain. This might reflect a younger source population referred for biopsy or higher incidence of immune complex crescentic glomerulonephritis, particularly among younger patients in Nanjing.…”

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confidence: 95%