Epidemiology of pediatric primary tumors of the nervous system: A retrospective study of 633 cases from a single Moroccan institution

Harmouch, A.; Taleb, M.; Lasseini, A.; Maher, Mohammad Hassan Kargar; Sefiani, S.

doi:10.1016/j.neuchi.2012.01.005

Cited by 17 publications

(13 citation statements)

References 10 publications

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“…Epidemiology-Amongst low grade astrocytomas, pilocytic astrocytoma was the commonest accounting for 25% of all the astrocytomas in our study which was in accordance with Rosemberg et al 28 (2006) and Harmouch et al 32 (2012) who found pilocytic astrocytomas as the commonest tumors in their study.…”

Section: Pilocytic Astrocytomasupporting

confidence: 92%

CT Evaluation of Pediatric Supratentorial Tumors

D.P¹,

Akshatha²,

Boruah³

et al. 2014

IOSRJDMS

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I. I nt roduct io nBrain tumors are the most common solid tumor of childhood and the second most common malignancy after the leukemias. Primary central nervous system tumors (CNS) are the most common solid neoplasms in children. The incidence of CNS tumors is 2-5 new cases per 100000 per year, which is stable throughout the World. About 7% of the reported brain and CNS tumors occur in children aged 0-19 years .1, 2Although infratentorial tumors predominate in children, supratentorial tumors are more common in the first 2 to 3 years of life 2 . The clinical manifestations in childhood with brain tumors are largely those of increased intracranial pressure. Headache is a common early symptom. Most other symptoms are non-specific and include vomiting, cranial neuropathies and stupor and coma in late stages. 3 The largest percentage of childhood tumors (17%) are located within the frontal, temporal, parietal and occipital lobes of the brain. For children aged 0-14 years, pilocytic astrocytomas, embryonal tumors, and malignant glioma are the common tumors. The most common histologies in adolescent ages 15 -19 years include tumors of the pituitary and pilocytic astrocytoma. 1 Supratentorial intraaxial tumors are not very common in children but they are histologically more varied than in adults. Although there have been several neuroradiological investigations, accurate diagnosis by imaging modalities alone remains difficult in all cases, and final diagnosis in most cases requires histological examination. However, neuroradiological information is valuable in predicting tissue character and histological type or grade, and in helping establish treatment strategies. 4,5 The imaging modalities used are mainly CT and MR imaging with newer modalities like MR and CT perfusion, PET and SPECT.CT has become the primary imaging investigation in cases of suspected brain tumors, surpassing many other invasive imaging modalities. It has considerably high sensitivity, it is non-invasive having no hazards except ionizing radiations. CT can predict the pathological nature of a lesion with reasonable degree of accuracy. CT scan is more accurate indicator of brain tumor, yet it is not always 100% accurate. 6 MRI has its advantage of being a radiation free and multi-planar imaging facility. Hence a lesion can be seen in three planes and accurate localization of the lesion can be done. This modality provides better soft tissue characterization and can clearly demonstrate peritumoral edema, but has disadvantages like high cost , requires a long time for acquisition of the data and hence cannot be used for restless patient particularly neonates, infants or even uncooperative children. It cannot be done in patients having metallic implants for which CT is the modality of choice. 3 Newer multi-slice helical CT scanners are capable of providing highly collimated sub millimeter thickness sectional images in extremely short acquisition times and thus areas of hyperostosis or bone destruction, intratumoral calcification and early intratumoral or ...

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Section: Pilocytic Astrocytomasupporting

confidence: 92%

CT Evaluation of Pediatric Supratentorial Tumors

D.P¹,

Akshatha²,

Boruah³

et al. 2014

IOSRJDMS

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“…Medulloblastoma is the most common malignant brain tumour in children, accounting for 20–25% of all paediatric brain tumours in high‐income countries (HIC). However, data from low and middle‐income countries (LMIC) describe large variations in the incidence of medulloblastoma ranging from 6.1% to 49.4% of all diagnosed brain tumours .…”

Section: Introductionmentioning

confidence: 99%

SIOP PODC adapted treatment recommendations for standard-risk medulloblastoma in low and middle income settings

Parkes

Hendricks

Ssenyonga

et al. 2014

Pediatr Blood Cancer

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Effective treatment of children with medulloblastoma requires a functioning multi-disciplinary team with adequate neurosurgical, neuroradiological, pathological, radiotherapy and chemotherapy facilities and personnel. In addition the treating centre should have the capacity to effectively screen and manage any tumour and treatment-associated complications. These requirements have made it difficult for many low and middle-income countries (LMIC) centres to offer curative treatment. This article provides management recommendations for children with standard-risk medulloblastoma (localised tumours in children over the age of 3-5 years) according to the level of facilities available.

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“…29 Pilocytic astrocytoma remains the main primary CNS tumor in childhood and adolescence; however, it is mostly benign. [30][31][32] Thus, although it is not the most frequent tumor in children and adolescents, medulloblastoma remains one of the main brain neoplasms in this age group.…”

Section: Discussionmentioning

confidence: 99%

Epidemiological Profile of Malignant Brain Neoplasms in the Northern Region of Brazil: data from the Cancer Hospital Registry of the Instituto Nacional de Câncer

Filho

Pinto

Jesus³

2017

Arq Bras Neurocir

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). Palavras-Chave► neoplasias encefálicas ► neoplasia maligna ► epidemiologia ResumoObjetivo Os tumores do sistema nervoso central (SNC) são considerados raros, com incidência de 3,4 casos a cada 100 mil indivíduos no mundo. Apesar de serem considerados raros, os tumores do SNC vêm ganhando importância epidemiológica devido ao aumento de sua incidência e mortalidade. No Brasil, há carência de pesquisas populacionais quando se trata de câncer no SNC, principalmente no Norte do país. Dessa forma, os autores objetivam traçar o perfil epidemiológico das neoplasias encefálicas malignas na região Norte, de 2001 a 2013. Métodos Os dados foram coletados do RHC-Inca (Registro Hospitalar de Câncer, Instituto Nacional do Câncer) e estratificados em: procedência, gênero, faixa etária, localização primária detalhada e tipo histológico. Foram analisados 742 casos. A maioria dos pacientes teve procedência de cidades interioranas, e houve predominância do sexo masculino. Resultados As faixas etárias mais acometidas foram de 0 a 9 anos e 30 a 49 anos, com decréscimo acentuado a partir dos 70 anos. O lobo frontal foi o mais acometido, seguido pelos lobos temporal e parietal. Os tumores astrocíticos compõem 64,3% do total, seguido pelos tumores embrionários (18,2%) e ependimários (7,4%). No grupo dos tumores astrocíticos, o astrocitoma, SOE (sem outra especificação), e o glioblastoma, SOE, corresponderam a 82,2% dos casos. No grupo dos tumores embrionários, o meduloblastoma correspondeu a 71,9%. Conclusão Ressalta-se a necessidade de mais estudos epidemiológicos nessa área, especialmente na região Norte, com vistas a identificação de fatores de risco, prevenção e diagnóstico precoce na população. AbstractObjective Tumors of the Central Nervous System (CNS) are considered rare, with an incidence of 3.4 cases per 100,000 individuals worldwide. Despite being considered

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Epidemiology of pediatric primary tumors of the nervous system: A retrospective study of 633 cases from a single Moroccan institution

Cited by 17 publications

References 10 publications

CT Evaluation of Pediatric Supratentorial Tumors

CT Evaluation of Pediatric Supratentorial Tumors

SIOP PODC adapted treatment recommendations for standard-risk medulloblastoma in low and middle income settings

Epidemiological Profile of Malignant Brain Neoplasms in the Northern Region of Brazil: data from the Cancer Hospital Registry of the Instituto Nacional de Câncer

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