Epidemiology of pancreatic adenocarcinoma

Simoes, Priya; Saldia, Amethyst; Kurtz, Robert C.

doi:10.21037/cco.2017.06.32

Cited by 38 publications

(37 citation statements)

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“…Overall survival is <5% and complete surgical resection is the most effective treatment approach (16). However, between 10 and 15% of patients with pancreatic cancer may be surgical candidates and the long-term survival rate is between 10 and 20% with surgical resection (17)(18)(19).…”

Section: Discussionmentioning

confidence: 99%

Experience-based surgical approach to pancreatic mucinous cystic neoplasms with ovarian-type stroma

et al. 2017

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Abstract. The present study aimed to elucidate the clinicopathological characteristics of resected mucinous cystic neoplasm (MCN) with ovarian-type stroma and identify a surgical approach for MCN treatment, on the basis of Republic of Korean (Yonsei University College of Medicine, Seoul, South Korea) and Japanese (Nippon Medical School, Tokyo, Japan) bi-institutional collaboration. The present study retrospectively reviewed 55 MCNs with ovarian-type stroma using pathological re-examination. Clinicopathological features and preoperative clinical parameters were evaluated to predict malignant alterations in MCNs. The proportion of surgically treated MCNs has recently been increasing. All patients included in the present study were female, with a mean age of 47.9±13.3 years. Mural nodules were noted in 8 patients (14.5%) and the mean cyst size was 6.1±4.2 cm. A total of 9 patients (16.4%) were identified to exhibit non-invasive mucinous cystadenocarcinoma. The number of patients with small tumors (R 2 =-0.079, P=0.038) and asymptomatic pancreatic MCNs (P= 0.022) was significantly increased (P<0.05), which resulted in the more frequent application of minimally invasive surgery (P<0.001). During the follow-up period (mean, 51.6 months; range, 1.1-242.8 months), no recurrence or tumor-associated mortality was identified. The presence of mural nodules (P=0.002) and a tumor size ≥4.5 cm (P=0.027) were identified as potential clinical parameters for predicting malignant transformation. The significance of mural nodules in predicting malignant transformation was increased in large MCNs (≥4.5 cm) of the pancreas compared with small MCNs (<4.5 cm) (P=0.002). Overall, non-invasive pancreatic MCNs are not aggressive, and minimally invasive pancreatectomy may be an effective approach for suitable patients.

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Section: Discussionmentioning

confidence: 99%

Experience-based surgical approach to pancreatic mucinous cystic neoplasms with ovarian-type stroma

et al. 2017

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“…With an incidence of 4.2 per 100,000, pancreatic cancer is the 12th-most common cancer in humans [ 4 ]. Within malignancies of the gastrointestinal tract, PDAC ranks second behind the most commonly occurring colorectal cancer [ 1 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

The Emerging Role of Cyclin-Dependent Kinases (CDKs) in Pancreatic Ductal Adenocarcinoma

García-Reyes

Kretz

Ruff

et al. 2018

IJMS

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The family of cyclin-dependent kinases (CDKs) has critical functions in cell cycle regulation and controlling of transcriptional elongation. Moreover, dysregulated CDKs have been linked to cancer initiation and progression. Pharmacological CDK inhibition has recently emerged as a novel and promising approach in cancer therapy. This idea is of particular interest to combat pancreatic ductal adenocarcinoma (PDAC), a cancer entity with a dismal prognosis which is owed mainly to PDAC’s resistance to conventional therapies. Here, we review the current knowledge of CDK biology, its role in cancer and the therapeutic potential to target CDKs as a novel treatment strategy for PDAC.

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“…Pancreatic ductal adenocarcinoma is the 12th most common cancer worldwide [116] and the fourth most fatal cancer in both men and women [117]. The incidence of PDAC is higher in North America and in Western Europe and it is more common in men than in women [116].…”

Section: Microbiota and Pancreatic Ductal Adenocarcinomamentioning

confidence: 99%

Pancreatic Diseases and Microbiota: A Literature Review and Future Perspectives

Gesualdo

Rizzi

Bonetto

et al. 2020

JCM

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Gut microbiota represent an interesting worldwide research area. Several studies confirm that microbiota has a key role in human diseases, both intestinal (such as inflammatory bowel disease, celiac disease, intestinal infectious diseases, irritable bowel syndrome) and extra intestinal disorders (such as autism, multiple sclerosis, rheumatologic diseases). Nowadays, it is possible to manipulate microbiota by administering prebiotics, probiotics or synbiotics, through fecal microbiota transplantation in selected cases. In this scenario, pancreatic disorders might be influenced by gut microbiota and this relationship could be an innovative and inspiring field of research. However, data are still scarce and controversial. Microbiota manipulation could represent an important therapeutic strategy in the pancreatic diseases, in addition to standard therapies. In this review, we analyze current knowledge about correlation between gut microbiota and pancreatic diseases, by discussing on the one hand existing data and on the other hand future possible perspectives.

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Epidemiology of pancreatic adenocarcinoma

Cited by 38 publications

References 0 publications

Experience-based surgical approach to pancreatic mucinous cystic neoplasms with ovarian-type stroma

Experience-based surgical approach to pancreatic mucinous cystic neoplasms with ovarian-type stroma

The Emerging Role of Cyclin-Dependent Kinases (CDKs) in Pancreatic Ductal Adenocarcinoma

Pancreatic Diseases and Microbiota: A Literature Review and Future Perspectives

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