Epidemiology of Paget’s disease of bone in the city of Recife, Brazil

Abstract

Epidemiological studies of Paget's disease of bone (PDB) have shown a remarkable geographical variation in the prevalence rates of the disease. In South America, the frequency is considered to be low, despite scant epidemiological data on this continent regarding the disease. The aim of this study was to evaluate the prevalence and incidence of PDB in one institution in the city of Recife, Northeast Brazil. All patients aged 45 years and over attending the Pernambuco Osteoporosis Centre at the Endocrine and Diabetes Department between January 2006 and December 2009 were assessed. Period prevalence and incidence density were calculated for each year for males and females separately, with confidence intervals and hypothesis test for difference between proportions. A total of 7,752 patients were assessed of which 53 presented with PDB. The total prevalence was 6.8 per 1,000 patients, and the incidence density for PDB was 50.3 per 10,000 person-years. Both prevalence and incidence increased during the period. Our data show that prevalence and incidence rates of PDB in Recife are comparable to those from Southern Europe. To our knowledge, this is the first epidemiological study of PDB in South America.

Paget disease of bone among hospitalized patients in Poland

“…In non-European countries, the PDB prevalence is lower than in European countries and varies widely. The total prevalence was 6.8 per 1,000 patients, and the incidence density for PDB at 50.3 per 10,000 person-years in Recife in South America [13]. In the USA, approximately 1-2% of the population are affected by PDB, with the northeastern region showing the highest prevalence [14].…”

Misdiagnosis of Paget’s Disease of Bone in a Congenital Generalized Lipodystrophy Patient: Case Report

“…Epidemiological data in South America are scarce. In Brazil, the most important prevalence study was conducted in a city located in the northeast region, which had European colonization, and the rates were comparable to those in southern Europe (6,7). The etiology is not fully known; however, it seems that genetic and environmental factors play a role (4,5).…”

Diagnosis and treatment of Paget's disease of bone: a mini-review

“…In Brazil, data on its incidence are scarce. An analysis of nearly 8,000 patients followed up in a specialized institution in the city of Recife between 2006 and 2009 identified 53 individuals with PDB, resulting in a total prevalence of 6.8 cases per 1,000 patients (13), which is equivalent to data from Southern Europe (14). Recently, a series of 134 cases recorded over a 15-year period was reported in the city of Florianopolis (15).…”