Epidemiology of Ovarian Cancer

Permuth-Wey, Jennifer; Sellers, Thomas A.

doi:10.1007/978-1-60327-492-0_20

Cited by 264 publications

(207 citation statements)

References 160 publications

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“…The incidence of ovarian cancer increases with age, and the average age at diagnosis is 63. The highest incidence is in the age group of 75-79 (2) . ovarian cancer symptoms might not be seen for a long time in the vast majority of women.…”

Section: Introductionmentioning

confidence: 97%

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Prognostic Factors In Epithelial Ovarian Carcinoma: A Reference Institution Experience

Öge¹,

Ozalp²,

Yalçın³

2011

J Turk Soc Obstet Gynecol

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Section: Introductionmentioning

confidence: 97%

“…In women, ovarian cancer is the fifth most common cancer, it is the second most common one among the gynecologic cancers, and the most common cause of gynecologic cancer deaths (1,2) . The incidence of ovarian cancer increases with age, and the average age at diagnosis is 63.…”

Section: Introductionmentioning

confidence: 99%

Prognostic Factors In Epithelial Ovarian Carcinoma: A Reference Institution Experience

Öge¹,

Ozalp²,

Yalçın³

2011

J Turk Soc Obstet Gynecol

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“…1 Mortality is high because women typically present with late-stage disease when the overall 5-year relative survival rate is 45% (reviewed in Ref. 2). The most important risk factor is having a family history of the disease (reviewed in Ref.…”

mentioning

confidence: 99%

About 1% of the breast and ovarian Spanish families testing negative for BRCA1 and BRCA2 are carriers of RAD51D pathogenic variants

Gutiérrez‐Enríquez

Bonache

Garibay

et al. 2013

Intl Journal of Cancer

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RAD51D mutations have been recently identified in breast (BC) and ovarian cancer (OC) families. Although an etiological role in OC appears to be present, the association of RAD51D mutations and BC risk is more unclear. We aimed to determine the prevalence of germline RAD51D mutations in Spanish BC/OC families negative for BRCA1/BRCA2 mutations. We analyzed 842 index patients: 491 from BC/OC families, 171 BC families, 51 OC families and 129 patients without family history but with early-onset BC or OC or metachronous BC and OC. Mutation detection was performed with high-resolution melting, denaturing high-performance liquid chromatography or Sanger sequencing. Three mutations were found in four families with BC and OC cases (0.82%). Two were novel: c.1A>T (p.Met1?) and c.66712_667123del, leading to the exon 7 skipping and one previously described: c.674C>T (p.Arg232*). All were present in BC/OC families with only one OC. The c.66712_667123del cosegregated in the family with one early-onset BC and two bilateral BC cases. We also identified the c.629C>T (p.Ala210Val) variant, which was predicted in silico to be potentially pathogenic. About 1% of the BC and OC Spanish families negative for BRCA1/BRCA2 are carriers of RAD51D mutations. The presence of several BC mutation carriers, albeit in the context of familial OC, suggests an increased risk for BC, which should be taken into account in the follow-up and early detection measures. RAD51D testing should be considered in clinical setting for families with BC and OC, irrespective of the number of OC cases in the family.

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“…Tubal ligation could possibly have aprotective effect via a reduction in utero ovarian blood flow resulting in local hormonal and growth factor levels, or via its protection against the ascent of infection. Various studies have shown that tubal ligation, use of oral contraceptives and other contraceptive devices reduce ovarian cancer risk 12,13,14 .…”

Section: Resultsmentioning

confidence: 99%

Epidemiological Risk Factors for Primary Ovarian Malignancy in Indian Population- A Case Control Study from a Tertiary Care Centre in Kerala

B¹

2017

jmscr

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Epidemiology of Ovarian Cancer

Cited by 264 publications

References 160 publications

Prognostic Factors In Epithelial Ovarian Carcinoma: A Reference Institution Experience

Prognostic Factors In Epithelial Ovarian Carcinoma: A Reference Institution Experience

About 1% of the breast and ovarian Spanish families testing negative for BRCA1 and BRCA2 are carriers of RAD51D pathogenic variants

Epidemiological Risk Factors for Primary Ovarian Malignancy in Indian Population- A Case Control Study from a Tertiary Care Centre in Kerala

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