Epidemiology of osteoarthritis: literature update

Vina, Ernest R.; Kwoh, C. Kent

doi:10.1097/bor.0000000000000479

Cited by 726 publications

(608 citation statements)

References 99 publications

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“…OA is the most frequent chronic arthropathy as well as the main cause of disability throughout the world: Overall, it is estimated to affect about 10% of men and 18% of women over 60 years of age . Such condition is a progressive and debilitating degenerative joint disease selectively affecting the synovial joints.…”

Section: Introductionmentioning

confidence: 99%

Osteoarthritis and type 2 diabetes: From pathogenetic factors to therapeutic intervention

Cannata

Vadalà

Ambrosio

et al. 2019

Diabetes Metabolism Res

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Summary Over the last decades, osteoarthritis (OA) and type 2 diabetes (T2D) prevalence increased due to the global ageing population and the pandemic obesity. They currently affect a substantial part of the Western world population and are characterized by enhancing the risk of disability and reduction of quality of life. OA is a multifactorial condition whose development derives from the interaction between individual and environmental factors: The best known primarily include age, female gender, genetic determinants, articular biomechanics, and obesity (OB). Given the high prevalence of OA and T2D and their association with OB and inflammation, several studies have been conducted to investigate the causative role of biological characteristics proper to T2D on the development of OA. This review aims to analyse the relationship between of OA and T2D, in order to explain the pathophysiological drivers of the degenerative process and to delineate possible targets to which appropriate treatments may be addressed in the near future.

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Section: Introductionmentioning

confidence: 99%

Osteoarthritis and type 2 diabetes: From pathogenetic factors to therapeutic intervention

Cannata

Vadalà

Ambrosio

et al. 2019

Diabetes Metabolism Res

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“…Its common risk factors include increasing age, obesity, previous joint injury, overuse of the joint, weak thigh muscles, and genetics (Chatterji, Byles, Cutler, Seeman, & Verdes, ; Palmer & Goodson, ). Epidemiology data show that 13.9% of adults aged 25 and older have clinical OA of at least one joint, whereas 33.6% of adults age 65 and older have OA (Neogi, ; Vina & Kwoh, ). The major symptom of this disease is pain, which may lead to stiffness and loss of mobility, as well as swelling around the joints (Arendt‐Nielsen & Graven‐Nielsen, ; Staud et al, ).…”

Section: Introductionmentioning

confidence: 99%

“…Its common risk factors include increasing age, obesity, previous joint injury, overuse of the joint, weak thigh muscles, and genetics (Chatterji, Byles, Cutler, Seeman, & Verdes, 2015;Palmer & Goodson, 2015). Epidemiology data show that 13.9% of adults aged 25 and older have clinical OA of at least one joint, whereas 33.6% of adults age 65 and older have OA (Neogi, 2013;Vina & Kwoh, 2018).…”

Section: Introductionmentioning

confidence: 99%

Mangiferin: Possible uses in the prevention and treatment of mixed osteoarthritic pain

Garrido-Suárez

Garrido

Piñeros

et al. 2019

Phytotherapy Research

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Osteoarthritis (OA) pain has been proposed to be a mixed pain state, because in some patients, central nervous system factors are superimposed upon the more traditional peripheral factors. In addition, a considerable amount of preclinical and clinical evidence has shown that, accompanying the central neuroplasticity changes and partially driven by a peripheral nociceptive input, a real neuropathic component occurs that are particularly linked to disease severity and progression. Hence, innovative strategies targeting neuroprotection and particularly neuroinflammation to prevent and treat OA pain could be introduced. Mangiferin (MG) is a glucosylxanthone that is broadly distributed in higher plants, such as Mangifera indica L. Previous studies have documented its analgesic, anti‐inflammatory, antioxidant, neuroprotective, and immunomodulatory properties. In this paper, we propose its potential utility as a multitargeted compound for mixed OA pain, even in the context of multimodal pharmacotherapy. This hypothesis is supported by three main aspects: the cumulus of preclinical evidence around this xanthone, some preliminary clinical results using formulations containing MG in clinical musculoskeletal or neuropathic pain, and by speculations regarding its possible mechanism of action according to recent advances in OA pain knowledge.

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“…Obesity is a significant and rapidly increasing global health issue (Wewege et al, ), affecting approximately 650 million adults worldwide (approximately 13% of the population) (World Health Organization, ). It is associated with several comorbidities, such as type 2 diabetes mellitus (American Diabetes, ), cardiovascular diseases (Parto and Lavie, ), cancer (Berger, ), dyslipidemia (Silva Figueiredo et al, ), nonalcoholic fatty liver disease (Ooi et al, ), osteoarthritis (Vina and Kwoh, ), and is characterized by increased adiposity (Galic et al, ). The increase of adipose mass is determined by the balance between lipogenesis and lipolysis (Coelho et al, ).…”

Section: Introductionmentioning

confidence: 99%

Identification of Suitable Reference Genes for Quantitative Gene Expression Analysis in Innervated and Denervated Adipose Tissue from Cafeteria Diet‐Fed Rats

Marques-Oliveira

Silva

Valadares

et al. 2019

Lipids

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Our previous studies show that cafeteria diet increases body adiposity, plasma insulin levels, and sympathetic activity to brown adipose tissue (BAT) and white adipose tissue (WAT) of Wistar rats, leading to rapid and progressive changes in the metabolic profile. The identification of suitable reference genes that are not affected by the experimental conditions is a critical step in accurate normalization of the reverse transcription quantitative real‐time PCR (qRT‐PCR), a commonly used assay to elucidate changes in the gene expression profile. In the present study, the effects of the cafeteria diet and sympathetic innervation on the gene expression of adrenoceptor beta 3 (Adrb3) from BAT and WAT were assessed using one of the most stable and one of the least stable genes as normalizers. Rats were fed the cafeteria diet and on the 17th day, interscapular BAT or retroperitoneal WAT was denervated and, 7 days after surgery, the contralateral innervated tissue was used as control. Ten reference genes were evaluated (18S, B2m, Actb, CypA, Gapdh, Hprt1, Rpl32, Tbp, Ubc, and Ywhaz) and ranked according to their stability using the following algorithms: geNorm, NormFinder, BestKeeper, and comparative delta threshold cycle (ΔC t) method. According to the algorithms employed, the normalization of Adrb3 expression by the least stable genes produced opposite results compared with the most stable genes and literature data. In cafeteria and control diet‐fed rats, the three most stable genes were Hprt1, Tbp, and Rpl32 for interscapular BAT and Tbp, B2m, and Hprt1 for retroperitoneal WAT, while the least stable genes were 18S, Actb, and Gapdh for both tissues.

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Epidemiology of osteoarthritis: literature update

Abstract: Application of these new findings may allow us to develop innovative strategies and novel therapies with the purpose of preventing new disease onset and minimizing disease progression.

Cited by 726 publications

References 99 publications

Osteoarthritis and type 2 diabetes: From pathogenetic factors to therapeutic intervention

Osteoarthritis and type 2 diabetes: From pathogenetic factors to therapeutic intervention

Mangiferin: Possible uses in the prevention and treatment of mixed osteoarthritic pain

Identification of Suitable Reference Genes for Quantitative Gene Expression Analysis in Innervated and Denervated Adipose Tissue from Cafeteria Diet‐Fed Rats

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