Epidemiology of oral yeast colonization and infection in patients with hematological malignancies, head neck and solid tumors

Schelenz, Silke; Abdallah, S.; Gray, Gill; Stubbings, Helen; Gow, Isobel; Baker, Peter; Hunter, Paul R.

doi:10.1111/j.1600-0714.2010.00937.x

Cited by 77 publications

(91 citation statements)

References 37 publications

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“…This result is higher thanthose obtained by Schelenz et al (2011), who found a prevalence of oral yeast colonization in 56.8% (227/400) of cancerpatients. C. albicans was also the predominant (74%) specie in this research, followed by C. glabrata (11.5%), C. tropicalis (2.6%), C. krusei (2.6%) and C. parapsilosis (1.9%).…”

Section: Discussioncontrasting

confidence: 54%

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Exogenous niacin treatment increases NADPH oxidase in kiwifruit

et al. 2018

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The aim of this study was to evaluate the frequency of Candida species between a non-hospitalized and a hospitalized population. For this purpose, samples of saliva were sampled through sterile swabs, moistened in peptone water and rubbed in the oral cavity of 140 individuals, from which, 70 were hospitalized patients from the Medical Clinic of a Teaching Hospital and the other 70 were non-hospitalized subjects. All saliva samples were plated in Sabouraud Dextrose agar added with Chloramphenicol and incubated at 36 °C for 48 hours. The morphology identification was performed through macroscopic and microscopic characterization, the CHROMagar Candida medium and the VITEK  system Yeast Biochemical Card (bio Mérieux SA, France). The results showed a colonization of Candida spp. in 85.7% the hospitalized individuals, where the species found were C. albicans (60%), C. tropicalis (23.4%), C. krusei (3.3%) and Candida spp. (13.3%). In the non-hospitalized individuals the colonization by Candida spp was 47.1%, and the species found were: C. albicans (45.5%), C.krusei (9.1%), C. guilliermondii (9.1% %), C. tropicalis (3.0%), C. famata (3.0%) and Candida spp. (30.3%). In spite of their presence in oral cavity in both groups, Candida spp. was more frequently isolated in hospitalized individuals, who were 6.73 times more likely to have this fungus in the oral cavity and were 3.88 times more likely to have Candida albicans. Nos indivíduos não-hospitalizados a colonização por Candida spp foi de 47,1%, e as espécies encontradas foram: C. albicans (45,5%), C. krusei (9,1%), C. guilliermondii (9,1%), C. tropicalis (3,0%), C. famata (3,0%) e Candida spp. (30,3%). Apesar de sua presença na cavidade oral em ambos os grupos, Candida spp. foi mais freqüentemente isolada em indivíduos hospitalizados, que foram 6,73 vezes mais propensos a ter este fungo na cavidade oral e foram 3,88 vezes mais propensos a ter Candida albicans. KeywordsPalavras-chave: Candida spp. oral, colonização, pacientes hosptalizados, infecções hospitalares.

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Section: Discussioncontrasting

confidence: 54%

“…C. albicans was also the predominant (74%) specie in this research, followed by C. glabrata (11.5%), C. tropicalis (2.6%), C. krusei (2.6%) and C. parapsilosis (1.9%). Finally, this and others authors reported a significant increased risk of clinical oral fungal infection during cancer therapy (Lalla et al, 2010;Schelenz et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Exogenous niacin treatment increases NADPH oxidase in kiwifruit

et al. 2018

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“…In France, in one hospital, 17% of neutropenic patients with acute leukemia were colonized with C. kefyr (13), whereas in three other hospitals, 4.8% of all Candida isolates from hematology wards were C. kefyr (more than twice as many as in nonhematology wards) (14). In contrast, C. kefyr accounted for only 0.7% of Candida species found in the oral cavity of cancer patients in a United Kingdom regional center (15), and this species was not found among candidal surveillance cultures in patients with HM treated in a Finnish hospital (16).…”

Section: Andida Kefyr (Formerly Candida Pseudotropicalis) Is a Yeasmentioning

confidence: 94%

Epidemiology of Candida kefyr in Patients with Hematologic Malignancies

et al. 2014

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g Candida kefyr is an emerging pathogen among patients with hematologic malignancies (HM). We performed a retrospective study at Johns Hopkins Hospital to evaluate the epidemiology of C. kefyr colonization and infection in HM patients between 2004 and 2010. Eighty-three patients were colonized and/or infected with C. kefyr, with 8 (9.6%) having invasive candidiasis (IC). The yearly incidence of C. kefyr colonization and candidemia increased over the study period (P < 0.01), particularly after 2009. In 2010, C. kefyr caused 16.7% of candidemia episodes. The monthly incidence of C. kefyr was higher during the summer throughout the study. In a cohort of patients with acute myelogenic leukemia receiving induction chemotherapy, risks for C. kefyr colonization included the summer season (odds ratio [OR], 3.1; P ‫؍‬ 0.03); administration of an azole (OR, 0.06; P < 0.001) or amphotericin B (OR, 0.35; P ‫؍‬ 0.05) was protective. Fingerprinting of 16 isolates by repetitive sequence-based PCR showed that all were different genotypes. The epidemiology of C. kefyr candidemia was evaluated in another hospital in Montreal, Canada; data confirmed higher rates of C. kefyr infection in the summer. C. kefyr appears to be increasing in HM patients, with prominent summer seasonality. These findings raise questions about the effect of antifungal agents and health care exposures (e.g., yogurt) on the epidemiology of this yeast.

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“…Schelenz et al [2] isolated 266 oral yeasts of the Candida genus from patients with hematological malignancies and head and neck solid tumors and found that 28.2% of the isolates were resistant and 23.7% were susceptible dose dependant (SDD) to fluconazole, itraconazole, ketoconazole, voriconazole, and caspofungin. The majority of these resistant strains were C. glabrata and C. krusei.…”

Section: Introductionmentioning

confidence: 99%

“…However, other non-Candida albicans emerging species have arisen, such as C. dubliniensis, C. lusitaniae, C. rugosa, C. norvegensis, C. kefy, C. lypolitica, and C. guilliermondii, due to a growing population of immunosuppressed patients and the use of broad-spectrum antibiotics [1,2]. Yeasts from the Candida genus are responsible for the majority of fungal infections in immunocompromised patients owing to the use of immunosuppressive drugs and characteristics of the individual, such as advanced age and systemic diseases.…”

Section: Introductionmentioning

confidence: 99%

Photodynamic inactivation of biofilms formed by Candida spp., Trichosporon mucoides, and Kodamaea ohmeri by cationic nanoemulsion of zinc 2,9,16,23-tetrakis(phenylthio)-29H, 31H-phthalocyanine (ZnPc)

et al. 2012

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Kodamaea ohmeri by cationic nanoemulsion of zinc 2,9,16,23-tetrakis(phenylthio)-29H, 31H-phthalocyanine (ZnPc) LASERS IN MEDICAL SCIENCE, LONDON, v. 27, n. 6, pp. 1205-1212, NOV, 2012 ). The biofilm cells were scraped off the well wall, homogenized, and seeded onto Sabouraud dextrose agar plates that were then incubated at 37°C for 48 h. Efficient PDI of biofilms was verified by counting colony-forming units (CFU/ml), and the data were submitted to analysis of variance and the Tukey test (p<0.05).All biofilms studied were susceptible to PDI with statistically significant differences. The strains of Candida genus were more resistant to PDI than emerging pathogens T. mucoides and K. ohmeri. A mean reduction of 0.45 log was achieved for Candida spp. biofilms, and a reduction of 0.85 and 0.84, were achieved for biofilms formed by T. mucoides and K. ohmeri, respectively. Therefore, PDI by treatment with nanostructured formulations cationic zinc 2,9,16,23-tetrakis (phenylthio)-29H, 31H-phthalocyanine (ZnPc) and a laser reduced the number of cells in the biofilms formed by strains of C. albicans and non-Candida albicans as well the emerging pathogens T. mucoides and K. ohmeri.

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Epidemiology of oral yeast colonization and infection in patients with hematological malignancies, head neck and solid tumors

Cited by 77 publications

References 37 publications

Exogenous niacin treatment increases NADPH oxidase in kiwifruit

Exogenous niacin treatment increases NADPH oxidase in kiwifruit

Epidemiology of Candida kefyr in Patients with Hematologic Malignancies

Photodynamic inactivation of biofilms formed by Candida spp., Trichosporon mucoides, and Kodamaea ohmeri by cationic nanoemulsion of zinc 2,9,16,23-tetrakis(phenylthio)-29H, 31H-phthalocyanine (ZnPc)

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