Epidemiology of Older Age Bipolar Disorder

Leistikow, Nicole; Lehmann, Susan W.

doi:10.1007/978-3-319-48912-4_1

Cited by 4 publications

(5 citation statements)

References 57 publications

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“…Since the groups differed in gender distribution and medications (see Results in Section 3), the analyzes were repeated using: (a) Betweensubjects factors of group and gender and (b) Removal of participants taking benzodiazepines. 2 The findings using these analyzes were essentially identical to the original findings and are therefore not presented. See Table S1 and S2 for Pearson product-moment correlations between cognitive insight (primary participant SSTICS total scores, care partner SSTICS total scores and SSTICS discrepancy score) and relevant demographic, clinical and cognitive measures.…”

Section: Exploratory Analyzesmentioning

confidence: 77%

“…Bipolar disorder (BD) in older adults is associated with disability, diminished quality of life, and comorbid medical conditions 1,2 . It also places significant demands on service providers and care partners.…”

Section: Introductionmentioning

confidence: 99%

“…) X2 (1) = 2.94, p = .09 Abbreviations: HDRS, Hamilton depression rating scale; OABD, older adults with bipolar disorder; OADEP, older adults with unipolar depression; SSTICS, subjective scale to investigate cognition in schizophrenia; YMRS, young mania rating scale. and care partners).…”

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confidence: 99%

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Executive functioning of older adults with bipolar disorder

Omer

Braw

Amiaz

et al. 2020

Int J Geriat Psychiatry

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Objectives: Despite their impact on daily functioning, we have limited understanding of the executive functioning of older adults with bipolar disorder (OABD). Even less is known about the possible differences in the executive functioning of OABD and older adults with unipolar depression (OADEP). Methods: After excluding acutely ill patients, the executive functioning of OABD was compared to that of OADEP and healthy controls (n = 22, n = 20, n = 22; respectively). Cognitive insight, a sub-domain of executive functioning, was operationalized as the discrepancy between the participants' self-reported cognitive functioning and appraisals that were made by their care partners. To complement the cognitive profiling, the groups were compared in information processing speed, verbal memory, and visual-spatial memory. Results: OABD were impaired in several cognitive domains compared to healthy controls, most prominently in executive functioning and memory. OABD had poorer executive functioning and visual-spatial memory than OADEP. The findings also tentatively point toward intact cognitive insight among OABD, while OADEP seem to have a heightened level of awareness of their cognitive impairment. Conclusions: OABD have a unique profile of cognitive impairment compared to OADEP. It is characterized by a more severe cognitive impairment, accompanied by relatively intact cognitive insight. The findings may help clarify the cognitive profile of OABD and assist in the development of cognitive rehabilitation programs tailored to their needs. They should, however, be considered preliminary and await further research.

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Section: Exploratory Analyzesmentioning

confidence: 77%

Section: Introductionmentioning

confidence: 99%

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Executive functioning of older adults with bipolar disorder

Omer

Braw

Amiaz

et al. 2020

Int J Geriat Psychiatry

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“…Shifting to the other side of the spectrum, our results indicated that quality of care in BD patients peaked in the 40 to 44 years old age group and dismounted in an almost steady decreasing pattern subsequently in the higher ages. As older age is accompanied by cognitive diminution, longer durations of illness, less euthymic periods, polypharmacy, more dysfunction due to mental health impairment, and increased physical comorbidity, the reduction of the quality of care in older age BD patients is both interpretable and in need of special attention (Dautzenberg et al, 2016; Leistikow & Lehmann, 2017).…”

Section: Discussionmentioning

confidence: 99%

Global, regional, and national burden and quality of care index (QCI) of bipolar disorder: A systematic analysis of the Global Burden of Disease Study 1990 to 2019

Aghababaie-Babaki,

Malekpour,

Mohammadi

et al. 2023

Int J Soc Psychiatry

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Background: Bipolar disorders (BD) are significant debilitating mental problems. Here, we introduced a novel index as a representative of the quality of care delivered to BD patients worldwide. Methods: The Global Burden of Disease (GBD) 2019 study was the primary data source on BD, including prevalence, incidence, and years lived with disability (YLDs). Secondary indices were created and transformed into a single component that accounted for most of the variation, using the Principal Component Analysis (PCA) method. This component, reported on a scale of 0 to 100, was presented as the quality of care index (QCI). The QCI was estimated in different age groups and areas within a 30-year time frame. Gender disparity ratio (GDR), as the female-to-male ratio of the QCI, was reported. Results: The Global QCI slightly increased from 50.4 in 1990 to 53.1 in 2019. The GDR value was 0.95 in 2019. The high-middle SDI quintile had the highest QCI estimate of 63.0, and the lowest QCI value of 36.9 was regarding the low SDI quintile. Western-Pacific Region and South-East Asia had the highest and lowest QCI among WHO regions, with estimates of 70.7 and 31.2, respectively. The age group of 20 to 24 years old patients reported the lowest QCI estimate of 30.2, and the highest QCI of 59.8 was regarding 40 to 44 years old patients. Conclusion: The QCI in BD had only a subtle increase from 1990 to 2019 and is in need of further improvement. Inequalities between different regions and age groups are considerable and require proper attention.

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“…Studies show that, as compared to younger adult patients with BD, OABD patients have more non-affective cognitive impairments (e.g., attention, memory, and executive functioning), more frequent episodes, and more need of mental health services. 25 These differences are associated with more impairments in social functioning as compared to the younger adult patient group. 26 Previously, we found non-affective cognition to be linked to social functioning in OABD patients (Orhan et al, 2018;van Liempt et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Is social functioning in older age patients with bipolar disorder associated with affective and/or non‐affective cognition?

Paans

Korten

Orhan

et al. 2022

Int J Geriat Psychiatry

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Objectives Previous research showed impairments in non‐affective cognition, affective cognition, and social functioning in adult patients with bipolar disorder (BD). Only 37% of adult BD patients recovers in social functioning, and both aspects of cognition are important constructs of influence. The role of affective cognition in older age bipolar disorder (OABD) patients is still unclear. Therefore, the aim of our study was to examine the separate and combined effects of affective cognition and non‐affective cognition on social functioning. Methods The current study included 60 euthymic patients (aged >60) of the Dutch Older Bipolar Study. Affective cognition was measured by Theory of Mind and Emotion Recognition. Non‐affective cognition was assessed through the measurements of attention, learning and memory, and executive functioning. Social functioning was examined through global social functioning, social participation, and meaningful contacts. The research questions were tested with linear and ordinal regression analyses. Results Results showed a positive association of all non‐affective cognitive domains with global social functioning. Associations between affective cognition and social functioning were non‐significant. Results did show an interaction between non‐affective and affective cognition. Conclusions Associations between non‐affective cognition and social functioning were confirmed, associations between affective cognition and social function were not found. For generalizability, studies with a greater sample size are needed. Conducting additional research about OABD patients and affective cognition is important. It may lead to more insight in impairment and guide tailored treatment that focusses more on all aspects of recovery and the needs of OABD patients.

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Epidemiology of Older Age Bipolar Disorder

Cited by 4 publications

References 57 publications

Executive functioning of older adults with bipolar disorder

Executive functioning of older adults with bipolar disorder

Global, regional, and national burden and quality of care index (QCI) of bipolar disorder: A systematic analysis of the Global Burden of Disease Study 1990 to 2019

Is social functioning in older age patients with bipolar disorder associated with affective and/or non‐affective cognition?

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