Epidemiology of nontuberculous mycobacteria isolations among central North Carolina residents, 2006–2010

Smith, Gordon S.; Ghio, Andrew J.; Stout, Jason E.; Messier, Kyle P.; Hudgens, Edward; Murphy, Mark S.; Pfaller, Stacy; Maillard, Jean Marie; Hilborn, Elizabeth D.

doi:10.1016/j.jinf.2016.03.008

Cited by 56 publications

(55 citation statements)

References 25 publications

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“…Similar to other reports, NTM isolations from pulmonary sites occurred most frequently [6, 7]. Pre-existing chronic lung diseases, especially chronic obstructive pulmonary disease, asthma and bronchiectasis, are the main risk factors for NTM pulmonary infection [4].…”

Section: Discussionsupporting

confidence: 71%

“…Previous investigations described increase rates of NTM disease in the elderly [6, 7, 16]. We found that the age distribution differed among isolation sites.…”

Section: Discussionmentioning

confidence: 53%

“…This is more than that described in literature, with prevalence around 20–25% [6, 7, 17]. Among them, skin and soft tissue infections were the most encountered.…”

Section: Discussionmentioning

confidence: 78%

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Nontuberculous Mycobacterial Infections in a French Hospital: A 12-Year Retrospective Study

et al. 2016

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BackgroundNontuberculous mycobacteria (NTM) are environmental organisms associated with a range of infections. Reports of NTM epidemiology are mainly focused on pulmonary infections and isolations, and extrapulmonary infections are less frequently described.MethodsWe conducted a retrospective study of NTM infections at the Bordeaux University Hospital, France, between January 2002 and December 2013. We used the microbiologic component of the American Thoracic Society/Infectious Diseases Society of America's pulmonary NTM disease criteria to define cases of pulmonary NTM, and patients with isolates from a normally sterile site were classified as having extrapulmonary disease.ResultsIn our setting, 170 patients were included. Pulmonary cases predominated (54.1%), followed by skin and soft tissue infections (22.9%), disseminated cases (10.6%), lymphadenitis (7.7%), bone and joint infections (2.9%) and the remaining 1.8% catheter-related infections. Overall, 16 NTM species were isolated. Mycobacterium avium (31.8%) and M. intracellulare (20%) were the most common species identified, followed by M. marinum (13.5%), M. kansasii (10.6%), M. xenopi (9.4%), rapidly growing mycobacteria (9.4%) and other slowly growing mycobacteria (5.3%). In general, NTM isolates were largely prevalent in people older than 50 (62.4%); patients aged 1–10 year-old exclusively yielded M. avium from lymph nodes, almost cases having being diagnosed after 2007. Among the 121 patients with complete follow-up, 78 (64.5%), 24 (19.8%), and 19 (15.7%) were cured, experienced relapse, or died, respectively.ConclusionIn our study, extrapulmonary NTM infections represented almost half of cases, consisting mainly in skin and soft tissue infections. The increase lymphadenitis cases in children after 2007 could be linked to the cessation of mandatory BCG vaccination in France. We observed similar cure rates (64%) between pulmonary and extrapulmonary infections.

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Section: Discussionsupporting

confidence: 71%

“…Previous investigations described increase rates of NTM disease in the elderly [6, 7, 16]. We found that the age distribution differed among isolation sites.…”

Section: Discussionmentioning

confidence: 53%

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Nontuberculous Mycobacterial Infections in a French Hospital: A 12-Year Retrospective Study

et al. 2016

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“…The Public Health Ontario Laboratory includes approximately 95% of all mycobacteria tests conducted in the province; these data have been key to describing dramatic increases in both NTM isolation and NTM PD prevalence, with an increase in the 5-year prevalence of disease from 29.3 per 100 000 persons in 1998-2002 to 41.3 per 100 000 persons during 2006-2010 [9]. In North Carolina, USA, a recent study obtained reports on NTM isolates from nearly all laboratories serving three counties during 2006-2010, representing approximately 95% of all isolates in those counties during that time [10]. The reports had information on age, sex, race and site of isolation, and found an overall infection prevalence of 13.6 per 100 000 during that period, with the highest prevalence in the older age groups [10].…”

mentioning

confidence: 99%

“…In North Carolina, USA, a recent study obtained reports on NTM isolates from nearly all laboratories serving three counties during 2006-2010, representing approximately 95% of all isolates in those counties during that time [10]. The reports had information on age, sex, race and site of isolation, and found an overall infection prevalence of 13.6 per 100 000 during that period, with the highest prevalence in the older age groups [10].…”

mentioning

confidence: 99%