Epidemiology of Multiple System Atrophy: A Prevalence and Pilot Risk Factor Study in Aquitaine, France

Chrysostome, Virginie; Tison, François; Yekhlef, Farid; Sourgen, C; Baldi, Isabelle; Dartigues, Jean‐François

doi:10.1159/000078506

Cited by 77 publications

(65 citation statements)

References 55 publications

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“…Therefore, MSA-C is considered to be the most common initial manifestation of MSA in the Japanese population. In contrast, parkinsonism is predominant from the onset among Caucasian MSA patients [3,7,13,15]. One study performed in Germany showed that the frequency of MSA-C was higher than that of MSA-P [16], but there may have been some bias in this epidemiological study because it was mainly based on neuroimaging data.…”

Section: Discussionmentioning

confidence: 86%

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MSA-C is the predominant clinical phenotype of MSA in Japan: Analysis of 142 patients with probable MSA

Yabe¹,

Soma²,

Takei³

et al. 2006

Journal of the Neurological Sciences

122

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We investigated the clinical features and mode of disease progression in 142 patients with probable multiple system atrophy (MSA) according to the Consensus Criteria. The subjects included 84 men and 58 women with a mean age at onset of 58.2 ± 7.1 years (range: 38-79 years). Cerebellar signs were detected in 87.3% of these patients at the time of initial examination, and were found in 95.1% of them at latest follow-up. MSA-C was diagnosed in 83.8% of the patients at their first examination.Parkinsonism was initially detected in 28.9% of the patients, increasing to 51.4% at the latest follow-up. Among all of the subjects, only 16.2% were classified as having MSA-P on initial examination. At the latest follow-up, parkinsonian features had become predominant over cerebellar features in 24.6% of the 65 patients with MSA-C who were followed for more than 3 years. Although parkinsonism usually masked the signs of cerebellar involvement in MSA-C patients, none of the patients with MSA-P at an early stage showed predominance of cerebellar features at the latest follow-up.Parkinsonism is the predominant feature of MSA among Western patients, even at an early stage, but this study showed that cerebellar deficits are the main feature in Japanese patients. This difference of disease manifestations between ethnic groups suggests that genetic factors may influence the clinical phenotype of MSA.

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Section: Discussionmentioning

confidence: 86%

“…Other disorders associated with parkinsonism, such as Parkinson's disease with autonomic failure, progressive supranuclear palsy (PSP), and diffuse Lewy body disease (DLBD), may often be misdiagnosed as MSA-P [7,8,9,10,11,12]. A neuropathological study showed that Table 1.…”

Section: Discussionmentioning

confidence: 99%

MSA-C is the predominant clinical phenotype of MSA in Japan: Analysis of 142 patients with probable MSA

Yabe¹,

Soma²,

Takei³

et al. 2006

Journal of the Neurological Sciences

122

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“…On the other hand, some epidemiological reports from Europe and the United States have shown MSA-P predominance [13,14]. The current study was community-based using a national registry database; thus, it was important that the previous finding of MSA-C predominance in Japan be confirmed in a community-based epidemiological study.…”

Section: Discussionmentioning

confidence: 93%

Epidemiology of Multiple System Atrophy in Hokkaido, the Northernmost Island of Japan

et al. 2015

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“…Most patients deteriorate rapidly and survival beyond 10 years after disease onset is unusual. MSA is less common than PD as epidemiological studies estimate a prevalence of 1.9-4.9 people per 100,000 (Chrysostome et al, 2004;Schrag et al, 1999).…”

Section: The Human Diseasementioning

confidence: 99%

Animal Models of Neurodegenerative Diseases

Ghorayeb

Page

Gaillard

et al. 2010

Neurochemical Mechanisms in Disease

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The use of animals as models of neurodegenerative disorders has allowed the determination of biological targets and biomarkers of several diseases, has yielded new therapeutical perspectives, and is essential before performing novel clinical assays. This review discusses the nature, use, and limits of animal models and how to obtain them for several neurodegenerative disorders such as multiple system atrophy, amyotrophic lateral sclerosis, and Huntington's disease, with a special emphasis on Parkinson's and Alzheimer's diseases. When possible, rodent, invertebrate and primate models are presented and discussed in relation to human disease. Finally, we highlight discrepancies between animal models and human neuropathology leading to question the pertinence of some of these findings to human disorders probably because of the wide spectrum of parameters defining a disease. Another point raised by these studies is the growing necessity to standardize the experimental procedures used to obtain an animal model, housing and breeding conditions, assessments of phenotypes investigated and, ultimately the interpretation of results obtained and their relevance to the pathology.

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Epidemiology of Multiple System Atrophy: A Prevalence and Pilot Risk Factor Study in Aquitaine, France

Cited by 77 publications

References 55 publications

MSA-C is the predominant clinical phenotype of MSA in Japan: Analysis of 142 patients with probable MSA

MSA-C is the predominant clinical phenotype of MSA in Japan: Analysis of 142 patients with probable MSA

Epidemiology of Multiple System Atrophy in Hokkaido, the Northernmost Island of Japan

Animal Models of Neurodegenerative Diseases

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