Epidemiology of Moderate-to-Severe Plaque Psoriasis in a Canadian Surveyed Population

Papp, Kim; Valenzuela, Fernando; Poulin, Yves; Bernstein, Geula M.; Wasel, Norman

doi:10.2310/7750.2010.09066

Cited by 13 publications

(13 citation statements)

References 46 publications

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“…Twenty‐two studies provided data on the natural history and long‐term outcomes of child‐onset psoriasis . Ten studies reported the percentage of adult patients with psoriasis with child‐onset disease.…”

Section: Resultsmentioning

confidence: 99%

The epidemiology of childhood psoriasis: a scoping review

et al. 2016

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What's already known about this topic?• The prevalence of psoriasis in children is lower than adults • A significant number of adults with psoriasis first developed skin disease in childhood • Genetic and environmental factors both play an important role in the onset of psoriasis • Disease associations, such as obesity, are an important area of current research activity What does this study add?• Mapping has shown a dramatic increase in the number of published studies over the past 25 years • Studies have been concentrated in Europe, Asia and North America; these studies have largely been case series or cross-sectional studies • Specific studies with standardised methodologies are needed to provide data on the frequency, clinical presentation, risk factors, associated diseases and long-term outcomes for child-onset psoriasis The Epidemiology of Childhood Psoriasis: A Scoping Review AbstractPsoriasis is an inflammatory non-communicable skin disease which affects both adults and children. At present the epidemiology and natural history of psoriasis are not widely understood. This scoping review aimed to map the existing literature on the epidemiology of child-onset psoriasis, provide a comprehensive, clinically useful review and identify research gaps for future studies.Search strategies were developed for OVID MEDLINE, OVID Embase, Google Scholar and hand-searching; 131 articles meeting the inclusion criteria and were mapped and 107 articles were included for data extraction.Over 25 years there has been a dramatic increase in the volume of published observational epidemiological studies on child-onset psoriasis. The majority were case series or crosssectional studies, concentrated in Europe, Asia and North America. The prevalence of childhood psoriasis was found to be higher in European countries, older children and females. Up to 48.8% of children had psoriasis in a first degree relative. The most frequent subtype was plaque psoriasis and initial site of presentation is most commonly scalp, limbs and trunk. Specific genetic differences have been found between the child-onset and adultonset populations. Case-control studies and cohort studies investigating risk factors for psoriasis onset, comorbidities and long-term health outcomes were extremely limited.The choice of study design and heterogeneity in methodology limit the validity and generalisability on the information, consistency of the results and comparability of the studies. Well-designed studies are needed to provide precise and consistent information about the frequency and clinical presentation, risk factors, associated diseases and longterm outcomes in child-onset psoriasis.

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Section: Resultsmentioning

confidence: 99%

The epidemiology of childhood psoriasis: a scoping review

et al. 2016

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“…Limitations to this study, as detailed elsewhere, 28,41 include the use of pre‐existing Canadian consumer panels and databases. Although these databases are developed with the intention that they should be representative of the general population, it should be noted that study subjects were not randomly sampled and may not necessarily be truly representative of the Canadian population.…”

Section: Discussionmentioning

confidence: 99%

“…Effective patient education is critical, 39 as is strengthening communication between patients and physicians, which should include a joint decision-making process and the selection of appropriate treatment options to improve overall management. 23,32,39,40 Limitations to this study, as detailed elsewhere, 28,41 include the use of pre-existing Canadian consumer panels and databases. Although these databases are developed with the intention that they should be representative of the general population, it should be noted that study subjects were not randomly sampled and may not necessarily be truly representative of the Canadian population.…”

Section: Discussionmentioning

confidence: 99%

A Canadian online survey to evaluate awareness and treatment satisfaction in individuals with moderate to severe plaque psoriasis

et al. 2010

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A total of 514 panelists completed the survey; 65% reported current moderate/severe/very severe psoriasis. Awareness of available treatment options ranged from 98% for prescription topical agents to 75% for photo/light therapy, and < 50% for prescription oral (49%) or injectable (35%) medications. A total of 92% of respondents had been treated with and 61% were currently taking prescription topical agents. Photo/light therapy had been used by 38% and was currently used by 7% of respondents. Prescribed oral medication had been taken by 25% and was currently used by 8%. Few subjects had been treated with injectables in the past (10%) or currently (5%). Overall, 24% of respondents were very satisfied with their current treatment. A total of 63% of respondents taking injectables were very satisfied, compared with 38% of those taking prescribed oral medication and 21% of those receiving photo/light therapy.Conclusions Most respondents with moderate to severe psoriasis were unaware of all treatment options; systemic treatments were not commonly utilized. Treatment satisfaction rates were low, highlighting the need to ensure greater patient education on and use of available therapeutic options.

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“…Psoriasis is a common immune-mediated inflammatory skin disease affecting 1–3% of the Canadian population [ 1 , 2 ]. It is characterized by sharply demarcated, erythematous, indurated plaques covered by silvery-white scales, as well as systemic comorbidities [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

The skin microbiome in psoriatic disease: A systematic review and critical appraisal

Yerushalmi

Elalouf

Anderson

et al. 2019

Journal of Translational Autoimmunity

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Background Psoriasis affects 1–3% of the Canadian population. Psoriatic arthritis (PsA), the most common comorbidity of psoriasis, affects up to 30% of psoriasis patients. The skin microbiome is hypothesized to play a role in the pathogenesis of psoriatic disease (PsD-psoriasis and PsA). Objective To summarize the current state of literature on the skin microbiome in PsD. Methods A systematic review was performed using searches in Ovid, Medline, Embase, Medline Epub Ahead of Print and In-Process & Other Non-Indexed Citations, and Cochrane Central Register of Controlled Trials (CENTRAL). Search was limited to humans and English language, with no limits for date or publication type. Results Of 4,032 citations identified, 9 studies met inclusion criteria (7 on psoriasis only and 2 studies compared the microbiome characteristics between psoriasis and PsA). Compared to healthy controls, lesions demonstrated a decreased alpha diversity, higher relative abundances of Firmicutes, and lower relative abundances of Actinobacteria. Less conclusive were genus-level results, which nonetheless demonstrated trends towards increased Streptococcus , Staphylococcus , and Corynebacterium and decreased Propionibacterium in lesions vs. control. Limitations Study designs were heterogeneous, including sampling technique and exclusion criteria. Conclusions Phyla- and selected genus-level characteristic of the psoriatic microbiome are presented; further research is warranted.

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Epidemiology of Moderate-to-Severe Plaque Psoriasis in a Canadian Surveyed Population

Abstract: the findings are consistent with a substantial burden attributed to moderate-to-severe plaque psoriasis in a Canadian population.

Cited by 13 publications

References 46 publications

The epidemiology of childhood psoriasis: a scoping review

The epidemiology of childhood psoriasis: a scoping review

A Canadian online survey to evaluate awareness and treatment satisfaction in individuals with moderate to severe plaque psoriasis

The skin microbiome in psoriatic disease: A systematic review and critical appraisal

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