Epidemiology of meningiomas

Baldi, Isabelle; Engelhardt, Julien; Bonnet, Caroline; Bauchet, Luc; Berteaud, Émilie; Gruber, A.; Loiseau, Hugues

doi:10.1016/j.neuchi.2014.05.006

Cited by 133 publications

(110 citation statements)

References 121 publications

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“…The incidence of meningiomas has been reported to be about threefold higher in women, with the greatest difference observed between the ages of 30 and 59. 43 In our study, the higher prevalence of meningiomas found than in a previously reported study (0.9% in ref. 13) may be attributed to the use of MRIs of higher spatial resolution.…”

Section: Discussioncontrasting

confidence: 60%

“…Asymptomatic meningiomas require close clinical and radiological follow-up to rule out quickly enlarging tumours. 43 Our sample was selected through a very accurate screening process to ensure that participants included were clinically and cognitively normal. Nevertheless, although Chiari malformations constituted an exclusion criterion, we found six participants who were unaware of harbouring them.…”

Section: Discussionmentioning

confidence: 99%

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Incidental findings on brain MRI of cognitively normal first-degree descendants of patients with Alzheimer's disease: a cross-sectional analysis from the ALFA (Alzheimer and Families) project

et al. 2017

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ObjectivesTo describe the prevalence of brain MRI incidental findings (IF) in a cohort of cognitively normal first-degree descendants of patients with Alzheimer's disease (AD).DesignCross-sectional observational study.SettingAll scans were obtained with a 3.0 T scanner. Scans were evaluated by a single neuroradiologist and IF recorded and categorised. The presence of white matter hyperintensities (WMH) was determined with the Fazekas scale and reported as relevant if ≥2.Participants575 participants (45–75 years) underwent high-resolution structural brain MRI. Participants were cognitively normal and scored over the respective cut-off values in all the following neuropsychological tests: Mini-Mental State Examination (≥26), Memory Impairment Screen (≥6), Time Orientation Subtest of the Barcelona Test II (≥68), verbal semantic fluency (naming animals ≥12). Clinical Dementia Rating (CDR) had to be 0.Results155 participants (27.0%) presented with at least one IF. Relevant WMH were present in 7.8% of the participants, and vascular abnormalities, cyst and brain volume loss in 10.7%, 3.1% and 6.9% of the study volunteers, respectively. Neoplastic brain findings were found in 2.4% of participants and within these, meningiomas were the most common (1.7%) and more frequently found in women. A positive correlation between increasing age and the presence of IF was found. Additionally, brain atrophy greater than that expected by age was significantly more prevalent in participants without a parental history of AD.ConclusionsBrain MRIs of healthy middle-aged participants show a relatively high prevalence of IF even when study participants have been screened for subtle cognitive alterations. Most of our participants are first-degree descendants of patients with AD, and therefore these results are of special relevance for novel imaging studies in the context of AD prevention in cognitively healthy middle-aged participants.Trial registration numberNCT02198586.

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Section: Discussioncontrasting

confidence: 60%

Section: Discussionmentioning

confidence: 99%

Incidental findings on brain MRI of cognitively normal first-degree descendants of patients with Alzheimer's disease: a cross-sectional analysis from the ALFA (Alzheimer and Families) project

et al. 2017

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“…Because of a sufficient number of cases, it was even possible to begin to study separately glioma and meningioma risks in a prospective agricultural cohort. Indeed, in view of differences in clinical and epidemiological features of gliomas and meningioma, it is sound to hypothesize that they have different etiologies . Another strength of the cohort is its representativeness as it targeted all individuals involved in agriculture, independently of gender, age, or occupational status, and was not restricted to pesticide applicators.…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, in view of differences in clinical and epidemiological features of gliomas and meningioma, it is sound to hypothesize that they have different etiologies. 6,28 Another strength of the cohort is its representativeness as it targeted all individuals involved in agriculture, 27 independently of gender, age, or occupational status, and was not restricted to pesticide applicators. Moreover, as the cohort enrolled all individuals who worked for 3 years or more in agriculture at any time in their lives, including retirees and those who left the industry even a long time ago, we assume that selection bias related to health (Healthy Worker Effect) remained limited.…”

Section: Discussionmentioning

confidence: 99%

Central nervous system tumors and agricultural exposures in the prospective cohort AGRICAN

Piel

Pouchieu

Tual

et al. 2017

Intl Journal of Cancer

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Studies in farmers suggest a possible role of pesticides in the occurrence of Central Nervous System (CNS) tumors but scientific evidence is still insufficient. Using data from the French prospective agricultural cohort AGRICAN (Agriculture & Cancer), we investigated the associations between exposure of farmers and pesticide users to various kinds of crops and animal farming and the incidence of CNS tumors, overall and by subtypes. Over the 2005-2007, 181,842 participants completed the enrollment questionnaire that collected a complete job calendar with lifetime history of farming types. Associations were estimated using proportional hazards models with age as underlying timescale. During a 5.2 years average follow-up, 273 incident cases of CNS tumors occurred, including 126 gliomas and 87 meningiomas. Analyses showed several increased risks of CNS tumors in farmers, especially in pesticide users (hazard ratio = 1.96; 95% confidence interval: 1.11-3.47). Associations varied with tumor subtypes and kinds of crop and animal farming. The main increases in risk were observed for meningiomas in pig farmers and in farmers growing sunflowers, beets and potatoes and for gliomas in farmers growing grasslands. In most cases, more pronounced risk excesses were observed among pesticide applicators. Even if we cannot completely rule out the contribution of other factors, pesticide exposures could be of primary concern to explain these findings.

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“…They represent 0,5 to 3% of all intracranial meningiomas [1,2], and observed more frequently at a younger age than meningiomas in other locations [3]. They are classically large, because their silent evolution.…”

Section: Introductionmentioning

confidence: 99%

Intraventricular Meningiomas, A Rare Location for a Common Tumor: About 2 Cases

En-Nhaili¹,

Chellaoui²,

Ibahiouine³

et al. 2017

IJRRT

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Submit Manuscript | http://medcraveonline.com offers to the neurosurgeons the opportunity to make precisely the diagnosis, and guide their surgical approaches. Meticulous and rational planning enable complete removal of these usually benign tumors, offering permanent cure and long term survival. This paper will discuss clinical, radiological findings, and surgical management of this pathological entity, through 2 cases of IVM managed in our neurosurgery department. First caseA 17 years old female, presented with increasing intracranial pressure syndrome, severe headache, vomiting, and papillary oedema grade1. The patient was without any sensory or motor deficit. The CT and MRI shows a huge intraventricular lesion located in the occipital Horne of the right lateral ventricle ( Figure 1). The patient underwent a ventricular shunting, and the tumor was excised in a second time. The removal was complete using a temporo parietal approach, and the post operative status was stable, with improvement of the headache. The histological exam indicates a fibroblastic meningioma (Figure 2). Second caseA 15 years old girl, consulting for severe headache, with vomiting, and diplopia. The physical examination shows no motor or sensory deficit, and right 6 th nerve pulsy, with papillary oedema grade 2. CT and MRI show a very large intraventricular tumor, located at the right lateral ventricle (Figure 3 & 4). The patient underwent ventricular shunting, and the tumor was removed in a second time. The excision was total using a temporo parietal approach, and the post operative status was simple, with improvement of the headache. The histological exam indicates a fibroblastic meningioma too. AbstractIntraventricular meningiomas IVM, make up 0,5-3% of all intracranial meningiomas, and represent one of the most challenging tumors in neurosurgery. Being initially asymptomatic usually attains a large size before detection. we review through 2 cases of IVM managed in our neurosurgery department, the clinical, radiological and evolutionary features of these lesions.

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Epidemiology of meningiomas

Cited by 133 publications

References 121 publications

Incidental findings on brain MRI of cognitively normal first-degree descendants of patients with Alzheimer's disease: a cross-sectional analysis from the ALFA (Alzheimer and Families) project

Incidental findings on brain MRI of cognitively normal first-degree descendants of patients with Alzheimer's disease: a cross-sectional analysis from the ALFA (Alzheimer and Families) project

Central nervous system tumors and agricultural exposures in the prospective cohort AGRICAN

Intraventricular Meningiomas, A Rare Location for a Common Tumor: About 2 Cases

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