Epidemiology of melanoma: the importance of correctly reporting to the cancer registries.

Fidanzi, Cristian; D’Erme, Angelo Massimiliano; Janowska, Agata; Dini, Valentina; Romanelli, Marco; Margiotta, Flavia Manzo; Viacava, Paolo; Bagnoni, Giovanni

doi:10.1097/cej.0000000000000747

Cited by 9 publications

(7 citation statements)

References 10 publications

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“…In the age group under 40 the number of women was twice the number of men. These results are in line with the latest published sex-specific trends published for populations all over Europe and USA indicating higher incidence among younger women, while men are affected mostly in their middle age [7][8][9][10][11]. These results coincide with the results published in the National Cancer Registry in the Republic of Serbia.…”

Section: Discussionsupporting

confidence: 91%

“…General epidemiological features of melanoma relating to the number of newly diagnosed cases and related mortality are mainly well established in many developed countries, but we miss the data on histopathological features of melanoma [7]. The National Cancer Registry in Serbia keeps only the data on newly diagnosed cases and number of related deaths, while important prognostic data such as tumor thickness according to Breslow and presence of ulcerations are missing [6].…”

Section: Discussionmentioning

confidence: 99%

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Clinicopathologic characteristics of cutaneous melanoma - A single-center retrospective study

et al. 2022

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Introduction/Objective Epidemiology of melanoma including the number of new cases and mortality have been established in most developed countries, but data on pathohistological features are mostly missing. The objective of the study was to investigate epidemiological, clinical and pathohistological features of melanoma patients and compare the results with trends in other countries. Methods Our sample comprised patients surgically treated for skin melanoma at the Hospital for Burns, Plastic and Reconstructive Surgery during 2015-2017. Pathohistological, clinical and demographic features of melanoma were studied. Results The retrospective study comprised 201 patients (109 men and 92 women) aged 25-87 years. Melanoma was more common in men than in women (54.2% vs. 45.8%). Melanoma in male population most commonly presented on the trunk, while in female on the trunk and lower extremities was almost the same. Superficial spreading melanoma was the most common type of melanoma (68.7%), without correlation with the gender. No correlation was observed in relation to the stage of the disease and patient?s sex (p = 0.294). A statistical difference was observed in relation to the type of melanoma and the Breslow classification (p < 0.001). Breslow?s thickness did not correlate with age nor with sex. In relation to tumor invasiveness, 12.4% of the lesions were classified as in situ lesions, while 87.6% lesions were invasive. The majority of patients were identified as stage pT1a. Conclusion This study can help to identify patients at high risk for melanoma and contribute to optimize screening efforts in a defined target population.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Clinicopathologic characteristics of cutaneous melanoma - A single-center retrospective study

et al. 2022

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“…Additionally, missing data across some of the study variables limits the statistical power of our analysis, particularly for the rural group of patients. Similarly, Fidanzi et al found that incomplete data in cancer registries underestimated incidence of melanoma 15 . This highlights the importance of notifying the appropriate national‐ and state‐specific cancer registries of all diagnosed melanoma cases as well as the associated socioeconomic variables, which would prevent underpowered studies in the future and provide more comprehensive data to inform investigations of factors leading to the identified disparities.…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, Fidanzi et al found that incomplete data in cancer registries underestimated incidence of melanoma. 15 This highlights the importance of notifying the appropriate national‐ and state‐specific cancer registries of all diagnosed melanoma cases as well as the associated socioeconomic variables, which would prevent underpowered studies in the future and provide more comprehensive data to inform investigations of factors leading to the identified disparities. Given these limitations and the evidence of disparities in this study, future investigations could further refine the definition of rural communities, assess the factors influencing access to care, including dermatologist density and socioeconomic variables, and address gaps in patient knowledge regarding skin cancer recognition and prevention.…”

Section: Discussionmentioning

confidence: 99%

The influence of rurality on melanoma diagnosis in Indiana: A retrospective cohort study

Xue,

Clark,

Morr

et al. 2024

Cancer Reports

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BackgroundResearch from across the United States has shown that rurality is associated with worse melanoma outcomes. In Indiana, nearly a quarter of all residents live in rural counties and an estimated 2180 cases of melanoma will be diagnosed in 2023.AimsThis study examines how geographical location affects the stage of melanoma diagnosis in Indiana, aiming to identify and address rural health disparities to ultimately ensure equitable care.Methods and ResultsDemographics and disease characteristics of patients diagnosed with melanoma at Indiana University Health from January 2017 to September 2022 were compared using Students t‐tests, Wilcoxon tests, chi‐squared or Fisher's exact tests. Patients from rural areas presented with more pathological stage T3 melanomas (15.0% vs. 3.5%, p < 0.001) in contrast to their urban counterparts. Additionally, rural patients presented with fewer clinical stage I melanomas (80.8% vs. 89.3%) and more clinical stage II melanomas (19.2% vs. 8.1%), compared to urban patients, with no stage III (p = 0.028). Concerningly, a significantly higher percentage of the rural group (40.7%) had a personal history of BCC compared to the urban group (22.6%) (p = 0.005) and fewer rural patients (78.0%) compared to urban patients (89.4%) received surgical treatment (p = 0.016).ConclusionPatients from rural counties in Indiana have higher pathological and clinical stage melanoma at diagnosis compared to patients from urban counties. Additionally fewer rural patients receive surgical treatment and may be at higher risk of developing subsequent melanomas.

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“…We retrospectively collected all MCC reports in the time range 2006-2021 from the surgical pathology archives of the University Hospital of Pisa, Italy, and from the Hospital of Livorno, Italy. Of note, a higher incidence of melanoma has been reported in this area of Italy (Bagnoni et al, 2019;Fidanzi et al, 2021Fidanzi et al, , 2022. Overall, we collected 94 cases.…”

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confidence: 99%

Epidemiology of Merkel cell carcinoma in Tuscany (Italy), 2006–2021

Fidanzi¹,

Troaca²,

Fanelli

et al. 2023

European Journal of Cancer Prevention

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Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer that still has a poor prognosis. MCC incidence has increased in recent years worldwide. The aim of our study was to perform an epidemiological retrospective study and to evaluate the impact of MCC clinical and pathological features on overall survival (OS) in a specific geographical area. We retrospectively collected 94 pathology reports from 2006 to 2021 that were present in the pathology archives of the University Hospital of Pisa and of the Hospital of Livorno. Laterality was different according to the site, and almost half of the lesions were T1 and nearly half of the patients had a clinical stage III. We reported a dramatic increase in MCC diagnoses in the last 5 years compared with the previous years, with a crude incidence rate of 1,15/100000 inhabitants, almost doubling the last reported data in Italy. Surgical margins status and ulceration were not related to OS. We have noticed some patients with a rapidly progressing disease and others showing a slow disease progression which should prompt the investigation of specific biomarkers or other features that could elucidate this striking difference in progressionfree survival and could potentially identify different subtypes of MCC. Considering the generally low incidence of MCC worldwide, larger cohorts would be necessary to validate our data and to obtain a better prognostic stratification.

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Epidemiology of melanoma: the importance of correctly reporting to the cancer registries.

Cited by 9 publications

References 10 publications

Clinicopathologic characteristics of cutaneous melanoma - A single-center retrospective study

Clinicopathologic characteristics of cutaneous melanoma - A single-center retrospective study

The influence of rurality on melanoma diagnosis in Indiana: A retrospective cohort study

Epidemiology of Merkel cell carcinoma in Tuscany (Italy), 2006–2021

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