Epidemiology of Massive Transfusion

Halmin, Märit; Chiesa, Flaminia; Vasan, Senthil K.; Wikman, Agneta; Norda, Rut; Rostgaard, Klaus; Pedersen, Ole Birger; Erikstrup, Christian; Nielsen, Kaspar René; Titlestad, Kjell; Ullum, Henrik; Hjalgrim, Henrik; Edgren, Gustaf

doi:10.1097/ccm.0000000000001410

Cited by 79 publications

(24 citation statements)

References 21 publications

(20 reference statements)

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“…Patients with UGIB require continuous monitoring, fluid therapy, and transfusion after admission, as well as complex treatments, including endoscopic, radiologic, or surgical treatment 34. In addition, apart from trauma and surgery, UGIB is one of the most common conditions requiring massive transfusion (MT) 5. A previous study showed that massive bleeding occurs in 5.7% of patients with total UGIB and was fatal in 70% of the patients with massive bleeding in this study 6…”

Section: Introductionmentioning

confidence: 60%

Performance of Three Scoring Systems in Predicting Massive Transfusion in Patients with Unstable Upper Gastrointestinal Hemorrhage

Lee

et al. 2019

Yonsei Med J

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PurposeAfter trauma and surgery, upper gastrointestinal bleeding (UGIB) is the most common condition that can require massive transfusion (MT). The present study aimed to analyze and compare the prognostic performance of the Glasgow-Blatchford (GB), pre-endoscopy Rockall (PER), and modified early warning (MEW) scores for predicting MT in patients with unstable UGIB.Materials and MethodsThis retrospective observational study included patients with UGIB from March 2016 to February 2018. Receiver operating characteristics analysis was performed to examine the prognostic performance of the GB, PER, and MEW scoring systems. Logistic regression analysis was used to identify independent risk factors for MT, after adjusting for relevant covariates. The primary outcome was MT.ResultsOf the 484 included patients with unstable UGIB, 19 (3.9%) received an MT. The areas under the curves (AUCs) of the GB, PER, and MEW scores for MT were 0.577 [95% confidence interval (CI), 0.531–0.621], 0.570 (95% CI, 0.525–0.615), and 0.767 (95% CI, 0.727–0.804), respectively. The AUC of the MEW score was significantly different from those of the GB and PER scores. In multivariate analysis, MEW score was independently associated with MT in patients with unstable UGIB (odds ratio, 1.495; 95% CI, 1.100–2.033; p=0.010).ConclusionIn unstable UGIB patients, MEW score had the best prognostic performance for MT among three scoring systems.

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Section: Introductionmentioning

confidence: 60%

Performance of Three Scoring Systems in Predicting Massive Transfusion in Patients with Unstable Upper Gastrointestinal Hemorrhage

Lee

et al. 2019

Yonsei Med J

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“…Finally, 6 studies [ 15 , 17 – 19 , 21 , 23 ] were included in our meta-analysis after full-text reading. Among them, there were 2 RCTs [ 18 , 19 ] and 4 RCSs [ 15 , 17 , 21 , 23 ]. General characteristics of the included RCTs can be seen in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

“…However, recently, other studies have reported different conclusions [ 18 , 23 ]. In the O’Neal et al study [ 18 ], the VAS scores of IV acetaminophen and placebo groups were compared, as well as total the morphine consumption, among other parameters.…”

Section: Discussionmentioning

confidence: 99%

“…O’Neal et al [ 18 ] reported that no significant differences were found between the IV acetaminophen and placebo groups regarding the VAS score. Similarly, Ciummo et al [ 23 ] declared that there was no statistically significant difference in average daily postoperative VAS score.…”

Section: Discussionmentioning

confidence: 99%

“…In Murata-Ooiwa et al’s study [ 19 ], there were no significant differences in the rate of complications. With regard to LOS, Ciummo et al [ 23 ] reported that no significant differences were found. Kelly et al [ 15 ] reported that the median length of LOS for both the IV acetaminophen and placebo groups was 3 days.…”

Section: Discussionmentioning

confidence: 99%

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Efficacy of intravenous acetaminophen in multimodal management for pain relief following total knee arthroplasty: a meta-analysis

et al. 2018

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BackgroundThe efficacy of intravenous acetaminophen in multimodal pain management in patients undergoing total knee arthroplasty (TKA) is controversial. The purpose of this meta-analysis was to compare the efficacy of intravenous acetaminophen versus placebo in TKA.MethodsRandomized controlled trials (RCTs) or retrospective cohort studies (RCSs) concerning related topics were retrieved from PubMed (1996–June 2018), Embase (1980–June 2018), and the Cochrane Library (CENTRAL June 2018). Any studies comparing intravenous acetaminophen with a placebo were included in this meta-analysis. Meta-analysis results were collected and analyzed by Stata 12.0. Subgroup analysis was performed according to the general characteristics of the patients.ResultsIn total, the patients from six studies met the inclusion criteria. Our meta-analysis results indicated that compared with a control group, intravenous acetaminophen was associated with reductions in total morphine consumption and visual analogue scale (VAS) score at postoperative day (POD) 3. However, there was no significant difference in morphine consumption at POD 1 or in VAS at POD 1 or POD 2. Moreover, there was no significant difference in the length of hospital stay.ConclusionsBased on our results, intravenous acetaminophen in multimodal management has shown better efficacy in pain relief at POD 3 and has morphine-sparing effects. High-quality studies with more patients are needed in the future.Electronic supplementary materialThe online version of this article (10.1186/s13018-018-0950-7) contains supplementary material, which is available to authorized users.

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Association Between Ratio of Fresh Frozen Plasma to Red Blood Cells During Massive Transfusion and Survival Among Patients Without Traumatic Injury

et al. 2017

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Epidemiology of Massive Transfusion

Cited by 79 publications

References 21 publications

Performance of Three Scoring Systems in Predicting Massive Transfusion in Patients with Unstable Upper Gastrointestinal Hemorrhage

Performance of Three Scoring Systems in Predicting Massive Transfusion in Patients with Unstable Upper Gastrointestinal Hemorrhage

Efficacy of intravenous acetaminophen in multimodal management for pain relief following total knee arthroplasty: a meta-analysis

Association Between Ratio of Fresh Frozen Plasma to Red Blood Cells During Massive Transfusion and Survival Among Patients Without Traumatic Injury

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