Epidemiology of malignant peritoneal mesothelioma: A population-based study

Salo, Silja A.S.; Ilonen, Ilkka; Laaksonen, Sanna; Myllärniemi, Marjukka; Salo, Jarmo A.; Rantanen, Tuomo

doi:10.1016/j.canep.2017.10.008

Cited by 21 publications

(21 citation statements)

References 19 publications

(34 reference statements)

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“…14 Their classification scheme was similar to the categorical analysis of PCI applied in this study. They considered PCI Score as the "T" component in their TNM staging system and divided PCI into four categories: T1 (0-10), T2 (11)(12)(13)(14)(15)(16)(17)(18)(19)(20), T3 (21-30) and T4 (31-39). 14 Magge et al have studied prognostic factors of MPeM and applied the Dutch simplified peritoneal cancer index (SPCI).…”

Section: Discussionmentioning

confidence: 99%

“…Ascites is a common radiographic finding and was observed in 79.2% of the patients. 21 While the median survival of patients with ascites was 7 months-compared to 39-months in patients without ascites-this result was not 13 Novel nomogram for 3-and 5-year overall survival 2014 Magge et al 12 The Dutch simplified peritoneal cancer index (SPCI)…”

Section: Discussionmentioning

confidence: 99%

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Prognostic role of radiological peritoneal cancer index in malignant peritoneal mesothelioma: national cohort study

Salo

Lantto

Robinson

et al. 2020

Sci Rep

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Malignant peritoneal mesothelioma (MpeM) is a rare cancer of the mesothelial cells of the peritoneum. Computed tomography (CT) is considered the standard for first-line imaging of MPeM, diagnosis and risk stratification remains challenging. Peritoneal cancer index (PCI), as assessed by CT, is utilized in the prognostic assessment of other malignant intra-abdominal conditions; however, there is limited data concerning the utility of PCI in the diagnosis and workup of MPeM. We studied a retrospective cohort of all patients diagnosed with MPeM from 2000 to 2012 in Finland. CT and magnetic resonance imaging (MRI) were reviewed and scored by an experienced and blinded, board-certified abdominal radiologist. Additional clinical data and outcomes were obtained from Finnish Cancer Registry (FCR), the Workers' Compensations Center (WCC), and Statistics Finland (SF). Abdominal CT or MRI was available for 53 of 90 patients. The median radiographic PCI was 25. PCI score was correlated with overall survival (p = 0.004, Exp(B) = 1.064, 95% CI 1.020-1.110). PCI score ≥ 30 was associated with worse survival (p = 0.002), while PCI ≤ 19 was associated with improved overall survival (p = 0.001). Our study indicates that radiological pci is prognostic in MpeM and should be assessed during radiographic workup and integrated into clinical decision-making. Malignant peritoneal mesothelioma (MPeM) is a rare cancer of the mesothelial cells of peritoneum, representing 7-30% of all mesothelioma diagnoses. 1 Signs and symptoms of MPeM are non-specific and include abdominal pain, abdominal distension, and weight loss. Given the rarity of the diagnosis and the non-specific presentation, diagnosis is often delayed. 2,3 Previous reports have indicated median time of 4-6 months between initial presentation and diagnosis. 4 Computed tomography (CT) of the chest, abdomen, and pelvis is the first-line imaging modality in the diagnostic workup of MPeM. 5 Ascites, peritoneal thickening, omental disease, small bowel involvement and solid and cystic masses are typical of MPeM on CT. 6-8 However, the sensitivity and specificity of CT in the diagnosis of MPeP is not described in the literature. The role of PET-CT in the diagnosis and workup of MPeM is likewise unclear. 9 Peritoneal mesothelioma is not well suited to traditional classification schemes like the TNM staging due to the rarity of distant metastases and the difficulty in discerning the full extent primary tumor versus local/regional spread. Several staging systems for MPeM have been proposed but to date have not been widely adopted. 10 Peritoneal cancer index (PCI) is a measure of disease spread developed for peritoneal carcinomatosis

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prognostic role of radiological peritoneal cancer index in malignant peritoneal mesothelioma: national cohort study

Salo

Lantto

Robinson

et al. 2020

Sci Rep

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“…Although an increasing percentage of patients receive anti-cancer therapy, the majority of The patient characteristics found in this study are comparable with those described in earlier reports. [9][10][11][12][13][14] Women with MPM live longer than men with MPM. It is sometimes suggested that the better survival among women is caused by a misdiagnosis of MPM because it has similarities to ovarian cancer.…”

Section: Discussionmentioning

confidence: 99%

Malignant Peritoneal Mesothelioma: Patterns of Care and Survival in The Netherlands. A Population Based Study.

Boer

Kooten

Damhuis³

et al. 2020

European Journal of Surgical Oncology

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Background. Malignant peritoneal mesothelioma (MPM) is a rare and aggressive disease. Recently, focus has shifted toward a more aggressive and multimodal treatment approach. This study aimed to assess the patterns of care and survival for MPM patients in the Netherlands on a nationwide basis. Methods. The records of patients with a diagnosis of MPM from 1993 to 2016 were retrieved from the Dutch Cancer Registry. Data regarding diagnosis, staging, treatment, and survival were extracted. Cox regression analyses and Kaplan-Meier survival curves were used to study overall survival. Results. Between 1993 and 2016, MPM was diagnosed for 566 patients. Overall, the prognosis was very poor (24% 1-year survival). The most common morphologic subtype was the epithelioid subtype (88%), followed by the biphasic (8%) and sarcomatoid (4%) subtypes. Surgical treatment has become more common in recent years, which most likely has resulted in improved survival rates. In this study, improved survival was independently associated with hyperthermic intraperitoneal chemotherapy (hazard ratio [HR], 0.33; 95% confidence interval [CI], 0.21-0.55) and surgery with adjuvant systemic chemotherapy (HR, Nadine L. de Boer and Job P. van Kooten contributed equally to this manuscript.

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“…Das diffuse maligne peritoneale Mesotheliom (DMPM) ist eine seltene Erkrankung, die häufiger bei Männern als bei Frauen vorkommt, wobei Überlebenszeiten von 4-13 Monaten berichtet wurden [1][2][3][4][5].…”

Section: Introductionunclassified

Das diffuse maligne peritoneale Mesotheliom (DMPM) – eine seltene Diagnose

Habbel

Mahler

Feyerabend³

et al. 2020

Z Gastroenterol

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ZusammenfassungDas diffuse maligne peritoneale Mesotheliom (DMPM) ist eine seltene Diagnose. Es tritt häufiger bei Männern als bei Frauen auf. Die Symptome sind vor allem unspezifische abdominelle Beschwerden, was die Diagnosestellung erschwert. Die Ursachen des DMPM sind noch nicht ausreichend geklärt. Ca. 7 % der peritonealen Mesotheliome lassen sich auf eine Asbestexposition zurückführen. Das DMPM war bis zur Entwicklung des Therapiekonzepts der systematischen chirurgischen Zytoreduktion (CRS) und anschließenden hyperthermen intraperitonealen Chemotherapie (HIPEC) eine fatale Diagnose mit einer medianen Lebenserwartung von 4–13 Monaten. Mit der CRS und HIPEC verbesserte sich die Prognose des DMPM deutlich auf 30–92 Monate heutzutage. Das vorliegende Fallbeispiel stellt die heute mögliche Therapie und deren Ergebnisse vor.

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Epidemiology of malignant peritoneal mesothelioma: A population-based study

Abstract: Our study indicates that MPeM in Finland is rare and fatal, which is in accordance with previous reports from other countries. MPeM is also a fatal disease, since most of the patients died due to MPeM.

Cited by 21 publications

References 19 publications

Prognostic role of radiological peritoneal cancer index in malignant peritoneal mesothelioma: national cohort study

Prognostic role of radiological peritoneal cancer index in malignant peritoneal mesothelioma: national cohort study

Malignant Peritoneal Mesothelioma: Patterns of Care and Survival in The Netherlands. A Population Based Study.

Das diffuse maligne peritoneale Mesotheliom (DMPM) – eine seltene Diagnose

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