Epidemiology of Lung Cancer

Mao, Yousheng; Ding, Yang; He, Jie; Krasna, Mark J.

doi:10.1016/j.soc.2016.02.001

Cited by 368 publications

(298 citation statements)

References 34 publications

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“…Globally, lung cancer (LC) is the one of the most frequent malignant tumor, with the leading cause of cancerrelated deaths (1). For pre-malignant and early-to-mid stages of LC, surgery remains the optimal treatment, although multidisciplinary treatments are also prevalent (2,3).…”

Section: Introductionmentioning

confidence: 99%

Short-term high-intensity rehabilitation in radically treated lung cancer: a three-armed randomized controlled trial

Huang¹,

Lai²,

Zhou³

et al. 2017

J. Thorac. Dis.

117

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Background:The feasibility and practicality of preoperative rehabilitation (PR) programs remains quite controversial in the treatment of lung cancer (LC). This study explored whether a short-term high-intensity rehabilitation program could improve postoperative outcomes compared to those achieved with conventional inspiratory muscle training (IMT).Methods: A three-armed randomized controlled trial comparing the two training modalities and routine care was conducted in surgical LC patients. Patient groups received one of three treatment regimens: (I) high-intensity pulmonary rehabilitation (PR) that combined IMT with conventional resistance training (CRT) (combined PR group); (II) conventional PR (single IMT group); or (III) routine preoperative preparation (control group). The primary endpoint was a change in the occurrence of post-operative pulmonary complications (PPCs) that occurred within 30 days after surgery, while secondary endpoints included changes in length of hospital stay, quality of life (QoL) scores, 6-min walk distance (6-MWD) and peak expiratory flow (PEF).Results: A total of 90 enrolled patients were randomized into three groups with a computer-based 1:1:1 ratio. The intention-to-treat analysis of the study revealed that, compared with the Control Group, the Combined PR Group had a significant increase in Conclusions: This hospital-based short-term program of PR combining high-intensity IMT with CRT was significantly superior to the conventional IMT program, indicating that this approach would be a feasible strategy for treating LC patients, especially those waiting operations with surgery-related risk factors.

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Section: Introductionmentioning

confidence: 99%

Short-term high-intensity rehabilitation in radically treated lung cancer: a three-armed randomized controlled trial

Huang¹,

Lai²,

Zhou³

et al. 2017

J. Thorac. Dis.

117

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“…Lung cancer is the most common malignancy worldwide, and the leading cause of cancer-related deaths 1. Despite advances in treatment, the prognosis remains poor, especially for patients with non-small cell lung cancer (NSCLC) 1 2.…”

Section: Introductionmentioning

confidence: 99%

Prognostic Value of Early Response Assessment Using (18F)Fdg-Pet in Patients with Advanced Non-Small Cell Lung Cancer Treated with Tyrosine-Kinase Inhibitors

et al. 2017

Journal of Investigative Medicine

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The purpose of this meta-analysis was to determine the prognostic value of early response assessment using (18F)fluorodeoxyglucose (FDG)-positron emission thermography (PET) in patients with advanced non-small cell lung cancer (NSCLC) treated with tyrosine-kinase inhibitors (TKIs). MEDLINE, PubMed, Cochrane, EMBASE, and Google Scholar databases were searched until August 1, 2016 using the keywords non-small cell lung carcinoma, positron-emission tomography, fluorodeoxyglucose, prognosis, disease progression, survival, erlotinib, gefitinib, and afatinib. Inclusion criteria were studies of patients with stage III or IV NSCLC treated with a TKI and had response assessed by FDG-PET. Outcome measures were overall survival (OS) and progression-free survival (PFS). Of the 167 articles identified, 10 studies including 302 patients were included in the analysis. In 8 studies, patients were treated with erlotinib, and in 2 they were treated with gefitinib. The overall analysis revealed that early metabolic response was statistically associated with improved OS (HR=0.54; 95% CI 0.46 to 0.63; p<0.001), and with longer PFS (HR=0.23; 95% CI 0.17 to 0.33; p<0.001). Early response of patients with NSCLC treated with TKIs identified on FDG-PET is associated with improved OS and PFS.

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“…Lung cancer is the most common cancer worldwide accounting for 19.4% of all the cancer related deaths[3]. …”

Section: Discussionmentioning

confidence: 99%

Lung cancer metastasis to the gastrointestinal system: An enigmatic occurrence

Badipatla

Yadavalli

Vakde

et al. 2017

WJGO

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Adenocarcinoma of the lung infrequently metastasizes to the gastrointestinal tract. We report a rare case of a 65-year-old male with no respiratory symptoms diagnosed with adenocarcinoma of the lung by histopathological examination of metastatic sites which included an ulcer in the gastric body and a mass in the rectum. Metastatic disease also involved the liver as well. Patient was treated with systemic chemotherapy but unfortunately expired five months after the diagnosis was made.

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Epidemiology of Lung Cancer

Cited by 368 publications

References 34 publications

Short-term high-intensity rehabilitation in radically treated lung cancer: a three-armed randomized controlled trial

Short-term high-intensity rehabilitation in radically treated lung cancer: a three-armed randomized controlled trial

Prognostic Value of Early Response Assessment Using (18F)Fdg-Pet in Patients with Advanced Non-Small Cell Lung Cancer Treated with Tyrosine-Kinase Inhibitors

Lung cancer metastasis to the gastrointestinal system: An enigmatic occurrence

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