Epidemiology of Laryngeal Cancer: Results of the Heidelberg Case-Control Study

Maier, H.; Tisch, M.

doi:10.3109/00016489709124063

Cited by 83 publications

(51 citation statements)

References 9 publications

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“…The risk of developing these lesions increases with duration of smoking, the type of tobacco and the practice of deep inhalation. Additional etiological factors are: industrial pollution, specific occupational exposures, nutritional deficiency and hormonal disturbance (54,55,(59)(60)(61). The role of human papilloma virus (HPV) infection is still unsolved (62).…”

Section: Etiologymentioning

confidence: 99%

Laryngeal preneoplastic lesions and cancer: challenging diagnosis. Qualitative literature review and meta-analysis.

Mannelli

Cecconi

Gallo

2016

Critical Reviews in Oncology/Hematology

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Abstract.Background: Multi-step cancerogenesis guides laryngeal cancer onset and it includes a wide variety of pre-cancerous lesions that are macroscopically challenging to identify and distinguish from initial cancerous foci. Since the treatment of laryngeal cancer and its precursor lesions has a great impact on important laryngeal basic functions, early detection and preoperative assessment are important for a curative and function-preserving therapy. Nowadays, despite the high number of more advanced diagnostic techniques and methods, unfortunately, it is not uncommon for different clinicians to use different nomenclature or to identify different stage for the same laryngeal lesion. From these observations, it is obvious that an instrument offering the possibility to detect precancerous lesions, early cancerous lesions, and satellite foci or second primaries would be the key to improving management and outcome in laryngeal patients. Object. Different modalities of diagnostic techniques of laryngeal lesions exist. Rather than difference between benign and obvious malignant diseases, more difficult is to detect the presence of precancerous epithelial alterations. Not all tests achieve the same diagnostic accuracy, hence this meta-analysis of literature aimed to synthesize the validity of each single diagnostic technique in identifying and staging laryngeal disease. Methods: A systematic review of literature was led searching for articles mentioning the following terms including their various combinations to maximize the yield: larynx, laryngeal precancerous lesions, laryngeal cancer, white light (WL) endoscopy, stroboscopy, contact endoscopy (CE), autofluorescence (AF), ultrasound (US), narrow band imaging (NBI), computed axial tomography (CAT), magnetic resonance imaging (MRI), positron emission tomography (PET), CAT/PET. Then, a quantitative analysis was carried on for paper published after 2005 onward, reporting a minumun series of 10 patients each study, declaring sensitivity and specificity of each diagnostic system. Results: The search identified 7215 publications, of which 3616 published after 2005, with a final results of a total of 214 articles stratified and included by our selection criteria. 42 out of 214 articles were selected for quantitative synthesis. 25 out of 41 studies had a quality score of ≥ 6 (good), 16 presented a score between 4 and 5 (fair). While objections can be raised about the pooling of different diagnostic procedures under the same group and the high level of heterogeneity in the meta-analyses, the inclusion of over 4400 laryngeal lesions makes the results fairly robust. Conclusions: A comprehensive overview of the most recent advances in laryngeal imaging technology combined with all of the information needed to interpret findings and successfully manage patients with voice disorders can be found herein. With these data, clinicians can riskstratify patients and select proper examination modalities in order to provide appropriate care. Moreover, study limitations, together with p...

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Section: Etiologymentioning

confidence: 99%

Laryngeal preneoplastic lesions and cancer: challenging diagnosis. Qualitative literature review and meta-analysis.

Mannelli

Cecconi

Gallo

2016

Critical Reviews in Oncology/Hematology

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“…Dusts (cement, metal, wood and others) are potential exposures among construction workers and may contribute to the excess of laryngeal cancer (13,14,27,32,(34)(35)(36).…”

Section: Discussionmentioning

confidence: 99%

“…The mean age generally accepted that laryngeal cancer is highly related to alcohol and tobacco consumption (1,5), but occupational and environmental factors also play a role (1,5,6). Inorganic acids (7)(8)(9)(10)(11), polycyclic aromatic hydrocarbons (PAH) (12), nickel (13,14), solvents (15), paints, grease, metalworking fluids (16,17), gasoline, diesel oil and mineral oil (18), and pesticides (11,13) have been linked with laryngeal cancer. Exposure to various dusts (19), including cement and metal (14), silica (20), and welding fumes (21), has been associated with an increased risk of cancer of the larynx.…”

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confidence: 99%

Occupation and the risk of laryngeal cancer in Turkey

Elci

Dosemeci²,

Blair³

2001

Scand J Work Environ Health

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“…Altogether 14 case-control studies (6 hospital-based, 8 populationbased) have investigated the relationship between asbestos and laryngeal cancer. While nearly all of these studies found odds ratios greater than one (6,12,14,(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37), the association was statistically significant in only three studies (12,36,37). The case-control design is generally well-suited to the study of rare diseases such as laryngeal cancer; however, the low prevalence of occupational asbestos exposure in the general population limits the statistical power of such studies, particularly when the sample size is small.…”

Section: Asbestosmentioning

confidence: 99%