Epidemiology of Kawasaki Disease in Asia, Europe, and the United States

Uehara, Ritei; Belay, Ermias D.

doi:10.2188/jea.je20110131

Cited by 464 publications

(447 citation statements)

References 33 publications

Supporting

Mentioning

392

Contrasting

Unclassified

Order By: Relevance

“…El país con más casos de enfermedad de Kawasaki es Japón con una incidencia de 298.6 casos/100 000 niños menores de 5 años, 7 le sigue Corea del Sur con una incidencia de 113.1/100 000 en niños menores de 5 años. En Estados Unidos hay aproximadamente 4 500 casos al año 8 y en México no se conoce el número real de casos porque no existe un registro de la enfermedad. El primer caso fue publicado por Rodríguez en 1977 9 y desde esa fecha sólo existen reportes aislados y series de casos muy pequeñas.…”

Section: Discussionunclassified

Enfermedad de Kawasaki: cuadro clínico, exámenes de laboratorio y lesiones coronarias

2015

View full text Add to dashboard Cite

Este artículo debe citarse como ABSTRACTKawasaki disease (KD) is a systemic acute vasculitis of unknown etiology that mainly (80%) affects patients under 5 years of age. KD presents with fever, bilateral non-purulent conjunctivitis, oral mucosa changes, cervical adenopathy, cutaneous changes in extremities and unspecific exanthema. Opportune diagnosis of KD is a challenge for clinicians, mainly because there are no specific tests, and clinical criteria originally described in 1967 are still valid. Laboratory changes in the acute phase of the disease are not specific nor diagnostic. Objectives:To describe the clinical features, laboratory findings, treatment employed and development of coronary artery aneurysms in the acute phase of patients with Kawasaki Disease (KD) treated in a tertiary care children's hospital in Mexico City.Methods: Retrospective and observational study in patients with diagnosis of Kawasaki Disease treated from August 1995 to December 2013. Information gathered included patient demographics, clinical features, laboratory results, treatment and echocardiographic findings in the acute phase of the disease. Results:We studied 338 cases of KD in 322 patients. Mean age at diagnosis was 38.94 ± 36.53 months, (range from 2 to 200 months). 66.9% of our patients were male with a male/female ratio of 2:1. Complete KD was diagnosed in 82.2% of our cases. 298 of the cases received intravenous immunoglobulin (IVIG). In 287 cases the fever resolved after 48 hours of administration of IVIG and only 12 cases required a second dose of IVIG. In the 1995 to 2003 period KD was diagnosed in 48 patients and 22 cases developed coronary artery lesions (45.8%), from 2004 to 2008 KD was diagnosed in 108 patients and 61 cases presented with coronary artery aneurysms (56.5%) and finally, in the 2009 to 2013 period, 182 cases of KD were diagnosed and 52 cases developed coronary artery aneurysms (28.61%). In the overall series, 4 patients died from cardiac complications in the acute phase of the disease. Conclusion:Diagnosis of KD is becoming more frequent and with an early recognition and prompt treatment, the development of coronary artery aneurysms is diminished.

show abstract

Section: Discussionunclassified

Enfermedad de Kawasaki: cuadro clínico, exámenes de laboratorio y lesiones coronarias

2015

View full text Add to dashboard Cite

show abstract

“…UU., oscila entre 6 y 15 casos por 100 000 niños, mientras que, en Europa, es de 4 a 5 casos por 100 000 niños. 4,5 En Argentina, la incidencia anual es de 4 casos cada 100 000 consultas. 6 Afecta a niños de entre 3 meses y 5 años de edad (más frecuentemente, de 18 a 24 meses de vida), con una relación varón/mujer de 1,3-2/1.…”

Section: Epidemiologíaunclassified

Enfermedad de Kawasaki: Consenso interdisciplinario e intersociedades

2016

Arch Argent Pediat

View full text Add to dashboard Cite

“…The high prevalence of KD in Asian (especially Japanese) strongly implies a genetic predisposition to developing KD, given that Japanese children with Western lifestyle still have the similar increased risk of developing the disease (41)(42)(43). The marked susceptibility of individuals of Northeast Asia descent to KD, compared with the susceptibility of those of European descent, has been maintained following the migration of North Asians to countries where there is a low incidence of the disease (44). Moreover, siblings with KD have a 10-fold higher risk of developing KD than the general population does, and children whose parents had KD have a twofold increased incidence of developing the disease (40,(45)(46)(47)(48)(49).…”

Section: Genetics and Kawasaki Diseasementioning

confidence: 99%

Precision Medicine for Kawasaki Disease

Chen

2015

MRAJ

View full text Add to dashboard Cite

Kawasaki disease (KD) is a multisystem inflammatory illness of infants and young children that could result in acute vasculitis. Death due to this systemic vasculitis syndrome most frequently results from thrombosed coronary artery aneurysms and coronary arteritis. Without treatment, 25% of children with KD develop coronary artery abnormalities. Current therapy for KD consists of intravenous immunoglobul within the first 10 days of fever onset; this treatment reduces the prevalence of coronary artery abnormalities to 5%. Advances in genetic and proteomic analysis have sparked a worldwide effort to identify genes and potential biomarkers

show abstract

Epidemiology of Kawasaki Disease in Asia, Europe, and the United States

Cited by 464 publications

References 33 publications

Enfermedad de Kawasaki: cuadro clínico, exámenes de laboratorio y lesiones coronarias

Enfermedad de Kawasaki: cuadro clínico, exámenes de laboratorio y lesiones coronarias

Enfermedad de Kawasaki: Consenso interdisciplinario e intersociedades

Precision Medicine for Kawasaki Disease

Contact Info

Product

Resources

About