Epidemiology of isotretinoin exposure during pregnancy

Dai, Wen; Labraico, James; Stern, Robert S.

doi:10.1016/0190-9622(92)70088-w

Cited by 123 publications

(85 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…1,2 Of those pregnancies that result in live births, approximately 48% to 82% of the children are healthy at birth. 3 There is not enough data to determine whether these infants progress to develop abnormalities. In one study, the authors followed children for 7 years after birth and found no incidence of further abnormalities.…”

Section: Teratogenicitymentioning

confidence: 99%

Preventing and Managing the Side Effects of Isotretinoin

Brelsford¹,

Beute²

2008

Seminars in Cutaneous Medicine and Surgery

123

111

View full text Add to dashboard Cite

Section: Teratogenicitymentioning

confidence: 99%

Preventing and Managing the Side Effects of Isotretinoin

Brelsford¹,

Beute²

2008

Seminars in Cutaneous Medicine and Surgery

123

111

View full text Add to dashboard Cite

“…5 La isotretinoína incrementa el riesgo de abortos espontáneos y mortinatos hasta un 40% en embarazos expuestos en el primer trimestre a este medicamento. 6 En los hijos de mujeres que toman isotretinoína más allá de la segunda semana de la concepción se ha comunicado un riesgo de hasta el 35% de desarrollar embriopatía por este medicamento. 7 La dosis de isotretinoína necesaria para generar teratogenicidad en seres humanos (1 mg/kg/día) es menor a la dosis mínima necesaria teratogénica en animales (mono 5 mg/kg/ día, rata 75 mg/kg/día), que se explica por una diferente toxicocinética, transferencia placentaria y metabolismo.…”

Section: Discussionunclassified

Embriopatía por isotretinoína con microtia-anotia y cardiopatía. Presentación de un caso

Pachajoa

Ordóñez

2012

Arch Argent Pediat

View full text Add to dashboard Cite

Presentación de casos clínicos RESUMENLa isotretinoína es un retinoide derivado de la vitamina A utilizado para el tratamiento del acné noduloquístico y refractario, pero ha sido catalogado como un medicamento teratogénico. Se ha comunicado un espectro de defectos congénitos que incluyen malformaciones craneofaciales, defectos cardíacos y defectos en el sistema nervioso con la exposición prenatal a este medicamento. Se presenta el caso de una recién nacida con antecedente de exposición prenatal a isotretinoína con defectos congénitos craneofaciales que incluyen parálisis facial, anotia derecha y microtia izquierda, y cardiopatía compleja. Palabras clave: isotretinoína, anormalidades congénitas, teratología. AbStRActIsotretinoin is a retinoid that derivates from vitamin A. It is indicated for recalcitrant nodular acne treatment, but it has been classified as teratogenic. A wide spectrum of birth defects including craniofacial, heart and nervous system malformations have been described associated to prenatal exposure to this drug. We report the case of a newborn with a history of prenatal exposure to isotretinoin with craniofacial defects, including facial paralysis, right anotia, left microtia and complex heart disease.

show abstract

“…Even one dose is thought to be able to induce congenital defects or spontaneous abortion [104]. The rate of birth defects ranges from 18 to 28%, including craniofacial, cardiac, central nervous system, thymic, and various other abnormalities [104][105][106]. Female patients of childbearing potential must have at least one or two negative pregnancy tests before starting treatment and practice effective contraception for 1 month prior to, during, and for 1 month after completing therapy.…”

Section: Isotretinoinmentioning

confidence: 99%

Acne Vulgaris

Kutlubay¹,

Keçici²,

Engın³

et al. 2017

Acne and Acneiform Eruptions

View full text Add to dashboard Cite

Acne vulgaris is a multifactorial disorder of the pilosebaceous unit. The clinical picture can range from mild comedones to fulminant, scarring cases. Approximately 83-100% of all adolescents experience acne vulgaris at some point of their lives. Although acne often tends to resolve following the adolescent period, many men and women continue to suffer from either active acne or postinflammatory scars into their twenties and thirties. Most patients with acne vulgaris are in the complicated adolescence period and thus carry a distinctive psychosocial burden. They possess a disease stigma on their skin for the external world to criticize every day. For all these reasons, acne is a disease which should be treated promptly and efficiently in all age groups. This chapter will provide a comprehensive and up-to-date review of pathophysiology of acne vulgaris, new molecular mechanisms on the evolving acne lesions, epidemiology of the disease, and latest treatment options. The molecular biology of acne lesions, novel treatment options including cosmetic approaches, their role in acne pathogenesis, pathophysiology, and mechanism of actions of the drugs, safety, and efficacy issues, and various treatment regimens will be discussed along with novel discoveries and areas in which further research is needed.

show abstract

Epidemiology of isotretinoin exposure during pregnancy

Cited by 123 publications

References 7 publications

Preventing and Managing the Side Effects of Isotretinoin

Preventing and Managing the Side Effects of Isotretinoin

Embriopatía por isotretinoína con microtia-anotia y cardiopatía. Presentación de un caso

Acne Vulgaris

Contact Info

Product

Resources

About