Epidemiology of Intracranial Meningioma

Abstract

Meningiomas are the most frequently reported primary intracranial neoplasms, accounting for approximately 25% of all such lesions diagnosed in the United States. Few studies have examined the risk factors associated with a diagnosis of meningioma with two categories of exposure, hormones (both endogenous and exogenous) and radiation, most strongly associated with meningioma risk. Limited data are also available on long-term outcomes for meningioma patients, although it is clear that the disease is associated with significant morbidity and mortality. Recent legislation passed in the United States (The Benign Brain Tumor Cancer Registries Amendment Act [H.R. 5204]) mandates registration of benign brain tumors such as meningioma. This will increase the focus on this disease over the coming years as well as likely increase the reported prevalence of the disease. The increased emphasis on research dedicated to the study of brain tumors coupled with the advent of new tools in genetic and molecular epidemiology make the current era an ideal time to advance knowledge for intracranial meningioma. This review highlights current knowledge of meningioma epidemiology and new directions for research efforts in this field.

Lifestyle factors and primary glioma and meningioma tumours in the Million Women Study cohort

“…However, due to a poor prognosis, they are responsible for 7% of the years of life lost from cancer before the age of 70 years (Cancer Research UK, 2007). Very little is known about the aetiology of central nervous system tumours, but environmental factors are thought to play a role (McKinney, 2004;Connelly and Malkin, 2007).The two most common types of central nervous system tumour are glioma and meningioma (Claus et al, 2005). Gliomas arise from glial cells, are found predominantly in the brain and to a lesser extent in the spinal cord or other parts of the central nervous system, and represent more than 70% of all brain tumours (Ohgaki and Kleihues, 2005).…”

“…The two most common types of central nervous system tumour are glioma and meningioma (Claus et al, 2005). Gliomas arise from glial cells, are found predominantly in the brain and to a lesser extent in the spinal cord or other parts of the central nervous system, and represent more than 70% of all brain tumours (Ohgaki and Kleihues, 2005).…”

Pulmonary metastases in patients with recurrent, treatment‐resistant meningioma

“…However, to our knowledge there is very limited literature regarding the percentage of patients with meningioma who also are harboring a different neoplasm, with only a weak association between meningioma and breast cancer reported. 31 As such, the most common etiology for isolated octreotide-positive pulmonary nodules remains lung cancer of both non-small cell and small cell type. 32,33 Because lung cancer is the second most common cancer in the United States, with an incidence of 60 cases per 100,000 individuals, 34 whereas meningioma has the highest age-adjusted incidence rate of all brain tumors (5.04 and 2.46 for females and males, respectively), 3 it is possible although very rare that the 2 neoplasms can coexist in the same patient.…”

Tumor cerebral e gravidez

“…Meningiomas -É o tumor cerebral mais relacionado com a gravidez 1,[13][14][15]18,24,25 . Estudos que analisaram os receptores hormonais dos meningiomas revelaram a presença de receptores de progesterona (PR) em até 95% do material estudado pela imuno-histoquímica.…”