Epidemiology of inflammatory bowel disease in the Songpa-Kangdong district, Seoul, Korea, 1986–2005: A KASID study

Yang, Suk‐Kyun; Yun, Sung‐Cheol; Kim, Jin-Ho; Park, Joon Yong; Kim, Hak Yang; Kim, Young‐Ho; Chang, Dong Kyung; Kim, Sang Woo; Song, In Sung; Park, Jong Beom; Park, Eui-Ryun; Kim, Kyung Jo; Moon, Gyoo; Yang, Soo Hyun

doi:10.1002/ibd.20310

Cited by 429 publications

(339 citation statements)

References 48 publications

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“…This survey investigated the approximate annual number of patients treated in each institution, and does not accurately reflect the incidence and prevalence of IBD in each country. However, marked increases have been reported in the incidence and prevalence of IBD over the last 10-20 years in Japan, Korea and China, suggesting that the results of this survey are consistent with the actual situation [17,18,19,20]. Consistent with previous studies, there are generally more UC than CD patients in the East Asian countries surveyed [1].…”

Section: Discussionsupporting

confidence: 80%

A Questionnaire-Based Survey on the Diagnosis and Management of Inflammatory Bowel Disease in East Asian Countries in 2012

et al. 2014

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Background and Aim: The prevalence and incidence of inflammatory bowel disease (IBD) are lower in East Asia than in Western countries; however, marked increases have recently been reported. The clinical diagnosis and medical management of IBD in East Asia differ from those in Western countries. A questionnaire-based survey was performed to gather physicians' current opinions on IBD in different East Asian countries. Methods: Representative International Gastrointestinal Consensus Symposium (IGICS) committee members provided a questionnaire to physicians in each East Asian country studied. The questionnaire mainly focused on the diagnosis and management of IBD. Results: There were 19 respondents from Japan, 10 from South Korea, 9 from the Philippines, 6 from China and 4 from Indonesia. Colonoscopy (100%) and histopathology (63%) were commonly used for the diagnosis in ulcerative colitis (UC). Conventional small bowel enteroclysis was still the most common diagnostic tool for assessing small bowel lesions in Crohn's disease (CD) in East Asia. The percentage of physicians who investigated the reactivation of Cytomegalovirus in severe or refractory patients with UC ranged from 0% in the Philippines and Indonesia to 100% in Japan and Korea. Most physicians in Korea, the Philippines, China and Indonesia chose thiopurines or anti-TNF therapy as the second-line treatment in severe refractory UC, whereas Japanese physicians preferred to use tacrolimus or leukocyte apheresis. Physicians in the Philippines and Indonesia preferred to use oral 5-aminosalicylic acid for newly diagnosed severe ileocecal CD. In contrast, Korean physicians chose oral steroids and most physicians in China and Japan preferred to use anti-TNF. Nutritional therapy to induce or maintain remission in patients with CD was commonly used in Indonesia, Japan and China. Targeted biopsies by conventional colonoscopy were the most preferred strategy for cancer surveillance in long-standing UC over random biopsies in this region. Conclusions: The present survey found that current diagnostic approaches and clinical management of IBD vary within East Asian countries.

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Section: Discussionsupporting

confidence: 80%

A Questionnaire-Based Survey on the Diagnosis and Management of Inflammatory Bowel Disease in East Asian Countries in 2012

et al. 2014

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“…Korea and other East Asian countries, once considered being a region in which IBD was extremely rare, have had a rapidly increasing number of patients with IBD. The population-based Korean data showed that the mean annual incidence rates of Crohn's disease (CD) and ulcerative colitis (UC) increased from 0.05 and 0.34 per 100000 persons, respectively, in 1986-1990 to 1.34 and 3.08 per 100000, respectively, in 2001-2005 [2] . Anti-TNF agents such as infliximab and adalimumab have been used with gradually increasing frequency since they were approved for IBD treatment in the mid 2000s in Korea [3][4][5] .…”

Section: Introductionmentioning

confidence: 99%

Significant risk and associated factors of active tuberculosis infection in Korean patients with inflammatory bowel disease using anti-TNF agents

Kim

Song

Cho

et al. 2015

WJG

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AIM:To evaluate the incidence and risk factors of Korean tuberculosis (TB) infection in patients with inflammatory bowel disease (IBD) undergoing anti-TNF treatment. METHODS:The data of IBD patients treated with anti-TNFs in 13 tertiary referral hospitals located in the southeastern region of Korea were collected retrospectively. They failed to show response or were intolerant to conventional treatments, including steroids or immunomodulators. Screening measures for latent TB infection (LTBI) and the incidence and risk factors of Retrospective Study ORIGINAL ARTICLEactive TB infection after treatment with anti-TNFs were identified. RESULTS:Overall, 376 IBD patients treated with anti-TNF agents were recruited (male 255, mean age of anti-TNF therapy 32.5 ± 13.0 years); 277 had Crohn's disease, 99 had ulcerative colitis, 294 used infliximab, and 82 used adalimumab. Before anti-TNF treatment, screening tests for LTBI including an interferon gamma release assay or a tuberculin skin test were performed in 82.2% of patients. Thirty patients (8%) had LTBI. Sixteen cases of active TB infection including one TB-related mortality occurred during 801 personyears (PY) follow-up (1997.4 cases per 100000 PY) after anti-TNF treatment. LTBI (OR = 5.76, 95%CI:1.57-21.20, P = 0.008) and WBC count < 5000 mm 3 (OR = 4.5, 95%CI: 1.51-13.44, P = 0.007) during follow-up were identified as independently associated risk factors. CONCLUSION:Anti-TNFs significantly increase the risk of TB infection in Korean patients with IBD. The considerable burden of TB and marked immunosuppression might be attributed to this risk.

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“…Because appendectomy is a reported risk factor for CD, the exclusion of patients with a history of appendectomy raises the possibility that some patients with a spontaneous perforation due to CD may have also been excluded. However, considering that the annual incidence of CD in Korea is 1.34/100,000, the possibility of a spontaneous perforation due to CD in cases with a history of appendectomy is thought to be very low [13]. Consequently, it is speculated that excluding those with a medical history of abdominal surgery did not significantly impact the results of our study.…”

Section: Discussionmentioning

confidence: 41%

“…Recently, it was reported that the incidence of inflammatory bowel diseases such as CD and ulcerative colitis is increasing in South Korea [13]. Another recent report showed that the incidence of small-bowel perforation due to typhoid enteritis decreased from 70% in 1984 to 14% in 2003, but the incidence of perforation due to CD increased from 0% in 1984 to 14% in 2003 [14].…”

Section: Discussionmentioning

confidence: 99%

Differential Diagnosis of Crohn's Disease and Intestinal Tuberculosis in Patients with Spontaneous Small-Bowel Perforation

Kim¹,

Kim²,

Jeong³

et al. 2014

Dig Surg

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Background/Aims: Spontaneous small-bowel perforation caused by Crohn's disease (CD) or intestinal tuberculosis (ITB) is a rare disease entity. We investigated the clinical features and radiologic findings of patients with CD or ITB who presented with a spontaneous small-bowel perforation. Methods: Between January 2001 and December 2010, sixty-two patients underwent surgery due to a spontaneous small-bowel perforation, including 21 (33.9%) CD patients and 18 (29.0%) ITB patients. Clinical and radiologic features were compared between CD and ITB patients. Results: The mean age was significantly lower in CD patients than in ITB patients (p = 0.014). Diarrhea was more common in CD. By contrast, night sweating and a previous history of tuberculosis were more common in ITB. Only 27.8% of patients with ITB had a positive QuantiFERON-TB Gold test. CT findings such as bowel wall thickening of more than 10 mm, omental thickening, and intra-abdominal lymphadenopathy larger than 10 mm were more common among perforations caused by ITB. Mesenteric fat infiltration was a more frequent finding in CD than in ITB. Conclusions: Clinical symptoms and radiologic findings may aid in the differential diagnosis between CD and ITB in patients presenting with spontaneous small-bowel perforation.

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Epidemiology of inflammatory bowel disease in the Songpa-Kangdong district, Seoul, Korea, 1986–2005: A KASID study

Abstract: The incidence and prevalence of CD and UC in Seoul, Korea, are still low compared with those in Western countries, but are rapidly increasing.

Cited by 429 publications

References 48 publications

A Questionnaire-Based Survey on the Diagnosis and Management of Inflammatory Bowel Disease in East Asian Countries in 2012

A Questionnaire-Based Survey on the Diagnosis and Management of Inflammatory Bowel Disease in East Asian Countries in 2012

Significant risk and associated factors of active tuberculosis infection in Korean patients with inflammatory bowel disease using anti-TNF agents

Differential Diagnosis of Crohn's Disease and Intestinal Tuberculosis in Patients with Spontaneous Small-Bowel Perforation

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