Epidemiology of infertility in China: a population‐based study

Zhou, Zehong; Zheng, Danni; Wu, Hongping; Li, R; Xu, Shuguang; Kang, Yuefan; Cao, Yunxia; Chen, X; Zhu, Yu; Zj, Chen; Mol, BW; Qiao, Jie

doi:10.1111/1471-0528.14966

Cited by 277 publications

(214 citation statements)

References 38 publications

(44 reference statements)

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“…Infertility is defined as the inability to conceive for at least 1 year (1). Infertility is a common condition affecting 10-20% of women at the reproductive age across different countries (2,3). Assisted reproductive technology (ART) has allowed millions of infertile couples in the world to conceive successfully since 1978 (4).…”

Section: Introductionmentioning

confidence: 99%

Melatonin Application in Assisted Reproductive Technology: A Systematic Review and Meta-Analysis of Randomized Trials

Wang

et al. 2020

Front. Endocrinol.

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Objective: To study whether melatonin treatment can increase clinical pregnancy rate and live birth rate in assisted reproductive technology (ART) cycles. Methods: Literature searches were conducted to retrieve randomized trials that reported the effect of melatonin treatment on ART outcomes. Databases searched included PubMed, EMBASE, Cochrane Library, Web of Science, and Google Scholar. Results: Ten studies matched the inclusion criteria. Clinical pregnancy was reported in all of the included studies and live birth was reported in three studies. Melatonin treatment significantly increased the clinical pregnancy rate [OR = 1.43 (1.11, 1.86), power = 0.98, 10 RCTs, low-quality evidence] but not the live birth rate [OR = 1.38 (0.78, 2.46), power = 0.34, 3 RCTs, low-quality evidence]. Melatonin treatment increased the number of oocyte collected [SMD = 0.34 (0.01, 0.67), 7 RCTs, low-quality evidence], the number of maturated oocyte [SMD = 0.56 (0.27, 0.85), 7 RCTs, low-quality evidence], and the number of good quality embryo [MD = 0.36 (0.18, 0.55), 3 RCTs, low-quality evidence]. Melatonin treatment significantly increased the biochemical pregnancy rate [OR = 1.65 (1.14, 2.38), 6 RCTs, low-quality evidence] and had no significant effect on the miscarriage rate [OR = 1.28 (0.65, 2.51), 5 RCTs, low-quality evidence]. Conclusion: Melatonin treatment significantly increases the clinical pregnancy rate but not live birth rate in ART cycles. Melatonin treatment also increases the number of oocyte collected, maturated oocyte, and good quality embryo. No clear evidence suggested that melatonin treatment increased the adverse events in ART cycles. The actual findings may be compromised due to the wide heterogeneity of the included IVF patients, from PCOS to low ovarian reserve.

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Section: Introductionmentioning

confidence: 99%

Melatonin Application in Assisted Reproductive Technology: A Systematic Review and Meta-Analysis of Randomized Trials

Wang

et al. 2020

Front. Endocrinol.

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“…Itis estimated that 1 out of 4 couples are infertile [2]. Latest epidemiological investigations have shown prevalence of infertility to be 25% in China [3]. Chromosomal abnormalities were associated with infertility [5] and maybe the major recognized genetic causes for recurrent miscarriage [9].…”

Section: Discussionmentioning

confidence: 99%

“…The prevalence of infertility is high around the world, it is estimated that 1 out of 4 couples are infertile [2]. The latest epidemiological investigation in China showed that among 10742 women, prevalence of infertility was 25.0% (2680/10742) [3].…”

Section: Introductionmentioning

confidence: 99%

Effects of Chromosomal Abnormalities on Assisted Reproductive Technology: A Retrospective Cohort Study

Cui

Lin

Wang

et al. 2020

Preprint

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Background: To ascertain whether couples with chromosomal abnormalities have a difference in cumulative clinical pregnancy rate and cumulative live birth rate among assisted reproductive technology population. Methods: Design: A retrospective cohort study. Setting: Department of reproduction and infertility in Chengdu Women's and Children's Central Hospital.Patients: A total of 112 couples were in exposed group with chromosomal abnormalities and 226 couples without chromosomal abnormalities in control group included in the study, totaling 338 cases. From 1st Jan 2017 to 31st Dec 2019. Control group (infertility couples without chromosomal abnormalities) was 1:2 matched by female age, type of infertility (primary, secondary), type of assisted reproductive technology (IVF, ICSI or IUI). Results: Primary outcomes: cumulative clinical pregnancy rate and cumulative live birth rate. The results indicated that chromosomes abnormalities had no statistical difference in primary outcomes. Further analysis revealed exposed group (couples with chromosomal abnormalities) had less 2 pronuclear stage count. The times of embryo transfer by ICSI was less than IVF in exposed group. We found out only female age had an effect on the primary results and the threshold was 33.5years old.Conclusions: There were no significant differences in cumulative clinical pregnancy rate and cumulative live birth rate between two groups. But 2 pronuclear stage count, and the times of embryo transfer were affected by chromosomal abnormalities. It may be better to choose ICSI and PGT in this population.

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“…[27] However, in discordance with the literature, most of the cases of infertility in the present study sample were of known causes. [28] This might be explained by the possibility of a selection bias given that the study setting may provide treatment for such underlying causes as the ovarian, tubal, or uterine treatable disorders.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of an Educational Program in Enhancing Infertile Women’s Psychological Health

Souilm¹,

Elkhalek²,

Hassan³

2018

AJNR

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Background: Infertility is a worldwide problem with negative impacts on psychological health of couples. Nurses have a crucial role in the mitigation of these problems. Aim of the study: To examine the effectiveness of a nursing intervention in enhancing infertile women's psychological health and improving associated disorders. Subjects and methods: The study was conducted in the outpatient department at Qena General Hospital using a one-group quasi-experimental design. It involved 90 infertile women attending the setting for management. An interview questionnaire form with four scales namely the General Health Questionnaire (GHQ), Narcissistic Personality Inventory, Experiences of Close Relationships-Revised (ECR-R), and the Defensive Style Questionnaire (DSQ-60) was used in data collection. The researcher designed and implemented by the researchers in the light of the needs identified in the pre-intervention assessment phase. The study was achieved through assessment, planning, implementation, and evaluation phases. Results: Women' age ranged between 21 and 47 years, mostly with primary infertility (80.0%). Statistically significant improvements were demonstrated at the post-intervention phase in all four domains of GHQ (p<0.001), and the mean total score increased from 39.6 to 68.0 (p<0.001). The total median narcissism personality score decreased from 24.50 before the intervention to 16.00 after the intervention (p<0.001). As for ECR-attachment scale, the median dropped from 4.16 to 3.11 (p<0.001). Similar statistically significant post-intervention improvements were revealed in the DSQ-60 scale. The multivariate analysis identified the study intervention as the main positive predictor of the GHQ score, a negative predictor of the narcissistic and ECR scores. Meanwhile, the study intervention was a positive predictor of the adapt DSQ domain whereas it was a negative predictor of the affect regulating domain score. Conclusion and recommendations: Infertile women suffer a number of psychological problems that are amenable to treatment through simple educational nursing interventions. Such educational endeavors should be implemented on a wide scale in all similar settings.

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Epidemiology of infertility in China: a population‐based study

Abstract: In China, 25% of couples actively attempting to become pregnant suffered infertility.

Cited by 277 publications

References 38 publications

Melatonin Application in Assisted Reproductive Technology: A Systematic Review and Meta-Analysis of Randomized Trials

Melatonin Application in Assisted Reproductive Technology: A Systematic Review and Meta-Analysis of Randomized Trials

Effects of Chromosomal Abnormalities on Assisted Reproductive Technology: A Retrospective Cohort Study

Effectiveness of an Educational Program in Enhancing Infertile Women’s Psychological Health

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