Epidemiology of <i>Helicobacter pylori</i> Infection in Asymptomatic Children: A Prospective Population‐Based Study from the Czech Republic. Application of a Monoclonal‐Based Antigen‐in‐Stool Enzyme Immunoassay

Sýkora, Josef; Siala, Konrad; Varvařovská, J; Pazdiora, P; Pomahačová, Renata; Huml, Michal

doi:10.1111/j.1523-5378.2009.00689.x

Cited by 55 publications

(71 citation statements)

References 54 publications

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“…The prevalence observed in this study was higher than reported for most European countries, and even many South American, African and Asian settings [19][20][21][22], where it ranged from less than 10% to 64%. The prevalence of infection was 69% in Vietnam, in adolescents aged between 10 and 14 years evaluated in 2005 [23], 78% Fig.…”

Section: Discussioncontrasting

confidence: 78%

Prevalence, incidence and risk factors for Helicobacter pylori infection in a cohort of Portuguese adolescents (EpiTeen)

Bastos

Peleteiro

Pinto

et al. 2013

Digestive and Liver Disease

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a b s t r a c tBackground: Helicobacter pylori infection is acquired mainly during childhood, but it may occur throughout life. Understanding the determinants of infection at different ages is essential to clarify dynamics of H. pylori related diseases and to design preventive strategies. Aim: To estimate the prevalence of H. pylori infection at the age of 13 and the incidence after a 3-year follow-up and to identify risk factors for infection. Subjects and methods: Adolescents born in 1990 were recruited in schools from Porto. Whole-cell anti-H. pylori IgG antibodies were quantified by ELISA. Prevalence ratios (PR) and incidence rate ratios (RR) adjusted for parental education were computed at baseline (n = 1312) and at follow-up (n = 280). Results: The prevalence was 66.2%, lower in subjects with more educated parents (PR = 0.72, 95%CI: 0.63-0.82), and higher for those having more than one sibling (PR = 1.10, 95%CI: 1.02-1.19) and for smokers (PR = 1.11, 95%CI: 1.02-1.20). The incidence was 4.1/100 person-years. Smoking (RR = 2.35, 95%CI: 1.16-4.75) and type of school (RR = 0.38, 95%CI: 0.16-0.95) were associated with the incidence of infection. Conclusions: Prevalence and incidence of H. pylori infection were high, suggesting that gastric cancer will remain an important public health problem in this generation of Portuguese. We identified smoking as a modifiable risk factor for infection.

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Section: Discussioncontrasting

confidence: 78%

Prevalence, incidence and risk factors for Helicobacter pylori infection in a cohort of Portuguese adolescents (EpiTeen)

Bastos

Peleteiro

Pinto

et al. 2013

Digestive and Liver Disease

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“…This finding is in agreement with other studies [37–39, 41, 42]. Education may mediate the observed association by influencing personal and household hygiene practices.…”

Section: Discussionsupporting

confidence: 93%

Helicobacter pylori infection in pregnant women in four districts of Uganda: role of geographic location, education and water sources

2014

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Background: The prevalence of Helicobacter pylori infection varies in relation to geography, ethnicity and socioeconomic factors. Available data on the prevalence of Helicobacter pylori infection in Uganda are not representative of the general population. We sought to describe the epidemiology of this infection in pregnant women in Uganda to provide background data for a study into the effect of H. pylori infection during pregnancy on the hematological response to iron supplementation. Methods: Using a cross-sectional design, H. pylori infection was assessed by the stool antigen test among 447 pregnant women attending antenatal care clinics in Apac, Mbale, Mbarara and Rakai Districts which are in different geographical regions in Uganda, and at Kawempe Health Center which serves a low-income densely populated area in Kampala City. Socio-demographic and household data were collected by face-to-face interviews using a questionnaire. Associations between H. pylori infection and socio-demographic and household characteristics were analyzed using logistic regression. Results: The overall prevalence of H. pylori infection was 45.2% but varied by geographical location from 18.2% in Apac District to 60.5% at Kawempe Health Centre. At 18.4%, the Langi ethnic group, who were enrolled exclusively in Apac District, had the lowest prevalence of H. pylori infection while the Gisu had the highest prevalence (58.4%). H. pylori was independently associated with enrollment at clinics not in Apac (adjusted OR = 5.68; 95% CI: 3.02-10.7) and with using water from public wells, boreholes or springs (AOR = 3.20; 95% CI: 1.19-8.61) and from rivers, lakes or streams (AOR = 5.20; 95% CI: 1.58-17.05). Urban residence (AOR = 1.71; 95% CI: 1.13-2.60) and no formal education (AOR = 1.95; 95% CI: 1.03-3.67) were also independently associated with H. pylori infection. Conclusions:The unexpected variation in the prevalence of H. pylori infection in Uganda calls for population-based studies in the region and offers an opportunity to study the transmission dynamics of H. pylori infection. The association between H. pylori infection and surface water sources for household use suggests waterborne transmission of H. pylori infection highlighting the need for concerted efforts in environmental health in communities and at the household level.

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“…W badaniu 1545 bezobjawowych dzieci w wieku 0-15 lat, wykonywanym metodą oznaczania antygenów H. pylori w kale, zakaże-nie stwierdzono u zaledwie 7,1% badanej grupy [19].…”

Section: Omówienieunclassified

“…Zagęszczenie lokali mieszkalnych jest znanym niezależnym czynnikiem ryzyka zakażenia H. pylori, co podkreślają autorzy wielu publikacji poświęconych epidemiologii zakażeń tą bakterią [6,19,22]. Interesującym zjawiskiem jest natomiast wykazany przez nas znacząco wyższy odsetek zakażeń u dzieci mieszkających w dużym, 200-tysięcznym mieście w porównaniu z małym miastem, liczącym ok. 10 tys.…”

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Decreasing prevalence of Helicobacter pylori infection in children in Poland

Krusiec-Świdergoł¹,

Kwiecień²,

Jonderko³

et al. 2010

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StreszczenieWstęp: Ostatnie duże badania dotyczące częstości zakażeń Helicobacter pylori (H. pylori) u dzieci w Polsce były prowadzone prawie 10 lat temu. Poprawa średnich przychodów i warunków życia w ciągu ostatnich lat pozwala przypuszczać, że odsetek za każeń H. pylori u dzieci powinien wykazywać stały trend spadkowy. Cel: Ocena aktualnej częstości występowania zakażenia H. pylori w populacji ogólnej dzieci szkolnych niemających objawów, zamieszkałych na terenach miejskich Górnego Śląska. Ocena wpływu wybranych czynników środowisko-wych na częstość zakażeń H. pylori oraz wpływ samego zakażenia na parametry antropometryczne badanych dzieci. Materiał i metody: Zbadano 415 dzieci w wieku 7-15 lat (śred-nia 10,8 roku). Wykonano u nich badanie w kierunku zakaże-nia H. pylori metodą mocznikowego testu oddechowego. Wyliczono parametry antropometryczne badanych dzieci oraz przeanalizowano ich warunki mieszkaniowe i środowiskowe. Wyniki: Zakażenie H. pylori wykazano u 15,7% badanej grupy. Nie stwierdzono różnic w średnim wieku dzieci zakażonych i niezakażonych (10,88 ±2,33 vs 10,74 ±2,34, p > 0,05). Status zakażenia H. pylori nie miał żadnego wpływu na wzrost, masę ciała, BMI oraz wskaźnik Cole'a badanych dzieci. Dzieci zakażone H. pylori miały znacznie gorsze warunki mieszkaniowe. Średnia liczba izb w miejscach zamieszkania dzieci zakażonych H. pylori była dużo mniejsza niż w miejscach zamieszkania dzieci niezakażonych (2,78 ±1,21 vs 3,41 ±1,26; p = 0,00038). Zagęszcze-nie, definiowane jako liczba domowników na izbę mieszkalną, było znacznie wyższe w grupie dzieci zakażonych H. pylori (1,92 ±1,18 vs 1,37 ±0,54, p = 0,00079). Wnioski: Obecnie częstość zakażeń H. pylori u dzieci bez objawów w populacji ogólnej w Polsce jest prawdopodobnie znacząco niższa niż podawana w dotychczasowych publikacjach. Złe warunki mieszkaniowe są ważnym czynnikiem ryzyka zakażenia H. pylori u dzieci. AbstractIntroduction: Previous large studies on the prevalence of Helicobacter pylori (H. pylori) infection in children in Poland were carried out about ten years ago. Since then an improvement in mean incomes and living conditions allows one to anticipate that the percentage of H. pylori infected children should be decreasing. Aim: To assess the current prevalence of H. pylori infection among asymptomatic school children from the general population living in the urban area of Upper Silesia (Poland); to assess the impact of environmental factors on the prevalence of H. pylori infection, as well as of the influence of the infection on the anthropometric parameters of children. Material and methods: 415 children aged 7-15 years (mean: 10.8 years) were examined. Their H. pylori status was diagnosed with the 13 C urea breath test. Anthropometric parameters of the children were recorded, and their living conditions and environmental factors were analysed. Results: Helicobacter pylori infection was diagnosed in 15.7% of children. There was no difference in the mean age of the infected and the non-infected children (10.88 ±2.33 vs. 10.74 ±2.34, p >...

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Epidemiology of Helicobacter pylori Infection in Asymptomatic Children: A Prospective Population‐Based Study from the Czech Republic. Application of a Monoclonal‐Based Antigen‐in‐Stool Enzyme Immunoassay

Cited by 55 publications

References 54 publications

Prevalence, incidence and risk factors for Helicobacter pylori infection in a cohort of Portuguese adolescents (EpiTeen)

Prevalence, incidence and risk factors for Helicobacter pylori infection in a cohort of Portuguese adolescents (EpiTeen)

Helicobacter pylori infection in pregnant women in four districts of Uganda: role of geographic location, education and water sources

Decreasing prevalence of Helicobacter pylori infection in children in Poland

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