Epidemiology of Helicobacter pylori Infection in the Czech Republic

Bureš, Jan; Kopáčová, Marcela; Koupil, Ilona; Voříšek, Viktor; Rejchrt, Stanislav; Beránek, M.; Seifert, Bohumil; Pozler, O; Živný, Pavel; Douda, Tomáš; Kolesárová, Mária; Pintér, Michal; Palička, Vladimír; Holčík, Jan

doi:10.1111/j.0083-8703.2006.00369.x

Cited by 62 publications

(53 citation statements)

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“…In this study the odds of having H.pylori infection increased as the age increased which coincides with what has been reported earlier 14,15,23 and contrary to data from Uganda where the prevalence was found to decrease as the age increased 24 . This could be explained by different study populations whereby in Uganda study the population studied was patients with different levels of malignancies.…”

Section: Prevalence and Factors Associated With Hpylori Infectionssupporting

confidence: 91%

Sero-prevalence and associated factors of Helicobacter pylori infection among adult patients with dyspepsia attending the gastroenterology unit in a tertiary hospital in Mwanza, Tanzania

Jaka¹,

Mushi

Mirambo

et al. 2016

Afr H. Sci.

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Background: Prevalence of H.pylori infection varies greatly between populations in different countries. This study was conducted to determine the magnitude of H.pylori among adult patients with dyspepsia attending the gastroenterology unit at Bugando medical centre. Methods: A cross sectional study involving 202 dyspeptic patients was conducted between June and July 2014. A Standardized data collection tool was used to collect socio-demographic characteristics. H.pylori antibodies were detected using rapid immunochromatographic tests according to manufacturer's instructions. Results: The median age of study population was 42 (IQR: 33-54). Females 105 (51.9%) formed majority of the population studied. Of 202 participants; 119 (58.9%) were from rural areas. Seroprevalence of H.pylori infection was found to be 79/202 (39.1%, 95% CI: 32.3 -45.7). As the age increased the risk of having H.pylori infection also increased (OR: 1.02 95% CI: 1-1.04, P=0.02). On multivariate logistic regression analysis untreated drinking water was found to predict H.pylori seropositivity (OR: 2.33, CI: 1.09-4.96, p=0.028). Conclusion:The seroprevalence of H.pylori among dyspeptic patients is high in this setting. Therefore the community in Mwanza should be educated on the use of safe drinking water in order to minimize H. pylori infections.

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Section: Prevalence and Factors Associated With Hpylori Infectionssupporting

confidence: 91%

Sero-prevalence and associated factors of Helicobacter pylori infection among adult patients with dyspepsia attending the gastroenterology unit in a tertiary hospital in Mwanza, Tanzania

Jaka¹,

Mushi

Mirambo

et al. 2016

Afr H. Sci.

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“…Previous reports demonstrated a linear birth cohort effect of H. pylori seroprevalence (6,7,9,(12)(13)(14) in other populations. In our study such an effect was not completely reproducible.…”

Section: Discussionmentioning

confidence: 89%

“…This proportion of positive H. pylori-related seroprevalence is similar to that reported from other European regions. The prevalence of active H. pylori infection was reported to be 41.7% for the Czech Republic in 2006 (6). Seroprevalences of 50.5% and 47% were found in Ireland and Italy, respectively (13,15).…”

Section: Discussionmentioning

confidence: 99%

Serological Prevalence of Helicobacter pylori Infection in Saxony-Anhalt, Germany, in 2010

Wex

Venerito

Kreutzer

et al. 2011

Clin Vaccine Immunol

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“…In developing countries, H. pylori transmission seems to happen preferentially but not exclusively among individuals who are closely related or living together (Schwarz et al 2008;Didelot et al 2013). However, in developed countries, improved hygienic conditions have decreased H. pylori prevalence, and transmission occurs primarily between family members, especially from mothers to children (Bures et al 2006;Chen et al 2007;Khalifa et al 2010;Krebes et al 2014). Further, an important epidemiological factor is that a human host is normally infected with H. pylori within the first 5 years of life and, unless treated, infection persists the entire host lifespan.…”

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confidence: 99%

Worldwide Population Structure, Long-Term Demography, and Local Adaptation of Helicobacter pylori

et al. 2015

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Helicobacter pylori is an important human pathogen associated with serious gastric diseases. Owing to its medical importance and close relationship with its human host, understanding genomic patterns of global and local adaptation in H. pylori may be of particular significance for both clinical and evolutionary studies. Here we present the first such whole genome analysis of 60 globally distributed strains, from which we inferred worldwide population structure and demographic history and shed light on interesting global and local events of positive selection, with particular emphasis on the evolution of San-associated lineages. Our results indicate a more ancient origin for the association of humans and H. pylori than previously thought. We identify several important perspectives for future clinical research on candidate selected regions that include both previously characterized genes (e.g., transcription elongation factor NusA and tumor necrosis factor alpha-inducing protein Tipa) and hitherto unknown functional genes.KEYWORDS adaptation; neutral evolution; human pathogens H ELICOBACTER pylori is a Gram-negative bacterium that infects the mucosa of the human stomach. It was first described in the 1980s, when it was initially identified in association with chronic gastritis and later causally linked to serious gastric pathologies such as gastric cancer and ulcers (Marshall and Warren 1984;Suerbaum and Michetti 2002). It infects .80% of humans in developing countries and, although its prevalence is lower in developed countries, nearly 50% of the worldwide human population is infected (Ghose et al. 2005;Salih 2009;Salama et al. 2013).Due to its clinical and evolutionary importance, there has been considerable research on mechanisms of H. pylori transmission, as well as on the population genetics and phylogenetic relationships among global isolates. Thus far, population genetic analyses have mainly focused on seven housekeeping genes (usually referred to as multilocus sequence typing or MLST), with the primary conclusions being that H. pylori strains appear highly structured, and their phylogeographic patterns correlate consistently with that of their human hosts. Given that the H. pylori-humans association is at least 100,000 years old (Moodley et al. 2012), the current population structure of H. pylori may be regarded as mirroring past human expansions and migrations Linz et al. 2007;Breurec et al. 2011) and thus help us shed light on yet unknown dynamics of local demographic processes in human evolution. However, despite the knowledge gained thus far, the long-term global demographic history of H. pylori has never been directly inferred. The long, intimate association of H. pylori with humans suggests a history of bacterial adaptation. Considerable attention has focused on specific genes involved in modulating adaptive immunity of the host (for a review see Yamaoka 2010 andSalama et al. 2013) and on genomic changes occurring during acute and chronic H. pylori infection (Kennemann et al. 2011;Linz et a...

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Epidemiology of Helicobacter pylori Infection in the Czech Republic

Cited by 62 publications

References 50 publications

Sero-prevalence and associated factors of <i>Helicobacter pylori</i> infection among adult patients with dyspepsia attending the gastroenterology unit in a tertiary hospital in Mwanza, Tanzania

Sero-prevalence and associated factors of <i>Helicobacter pylori</i> infection among adult patients with dyspepsia attending the gastroenterology unit in a tertiary hospital in Mwanza, Tanzania

Serological Prevalence of Helicobacter pylori Infection in Saxony-Anhalt, Germany, in 2010

Worldwide Population Structure, Long-Term Demography, and Local Adaptation of Helicobacter pylori

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