Epidemiology of Hydatidiform Moles in a Tertiary Hospital in Thailand over Two Decades: Impact of the National Health Policy

Wairachpanich, Varangkana; Limpongsanurak, Sompop; Lertkhachonsuk, Ruangsak

doi:10.7314/apjcp.2015.16.18.8321

Cited by 5 publications

(3 citation statements)

References 13 publications

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“…The estimated incidence of hydatidiform mole and GTN in Cambodia was lower than that in neighboring countries. The incidence of hydatidiform mole (per 1000 pregnancies or 1000 deliveries) was reported as 1.9 in Vietnam, 15 1.70 in Thailand, 21 1.8 in Thai‐Myanmar border, 22 2.8 in Malaysia, 23 2.3 in Indonesia, 24 and 2.4 in the Philippines 25 . The incidence of GTN (per 100 000 pregnancies or 100 000 deliveries) was 100 in Thailand 26 and 121 in Indonesia, 24 although fewer studies on GTN were reported compared to studies on hydatidiform mole.…”

Section: Discussionmentioning

confidence: 99%

The current situation of health services for hydatidiform mole in Cambodia

Yamamoto

Kanal²,

Soeung³

et al. 2021

J of Obstet and Gynaecol

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Aim: Management of hydatidiform mole is important to reduce the mortality and morbidity of choriocarcinoma. This study aims to understand the existing health services for hydatidiform mole and to estimate the incidence of gestational trophoblastic disease (GTD) in Cambodia. Methods: A questionnaire was used to collect information on the existing health services for pregnancy and hydatidiform mole at health facilities from attendants of the 16th Annual Conference of the Cambodian Society of Gynecology and Obstetrics in 2017. The incidence of GTD in 2014-2017 was estimated using Health Information System data. Results: A total of 126 attendants, who were from all provinces except three provinces, answered the questionnaire. The work places were national hospitals (n = 29), provincial hospitals (n = 42), district hospitals (n = 20), health centers (n = 6), and others (n = 29). The answers of participants from the public sector suggested the following: Ultrasonography is available at all hospitals but not health centers; Human chorionic gonadotropin (hCG) measurement is only available at national hospitals; Treatment of hydatidiform mole is performed at national hospitals and provincial hospitals; and Treatment of gestational trophoblastic neoplasia (GTN) is provided at national hospitals. The incidence of hydatidiform mole and GTN at health facilities in the public sector in 2014-2017 was 0.95 per 1000 deliveries and 6.58 per 100 000 deliveries, respectively. Conclusions: The results suggest that provincial hospitals are important to detect suspected invasive mole and refer to national hospitals for diagnosis and treatment. Further studies on the management of GTD and development of the guidelines of GTD are needed.

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Section: Discussionmentioning

confidence: 99%

The current situation of health services for hydatidiform mole in Cambodia

Yamamoto

Kanal²,

Soeung³

et al. 2021

J of Obstet and Gynaecol

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“…In Thailand, there is a higher rate of developing postmolar GTN which was approximately 26%. 3 Prophylactic chemotherapy may reduce the risk of progression to postmolar GTN. However, this practice is not generally recommended because it may increase drug resistance, delays treatment, and most importantly, it may expose women to unnecessary toxic side effects.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA Expression Profiling in Hydatidiform Mole for the Prediction of Postmolar GTN

Teerapakpinyo

Areeruk

Tantbírójn

et al. 2022

Technol Cancer Res Treat

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Objectives: The primary aim of the study was to identify miRNAs that were differentially expressed between complete hydatidiform moles (CHMs) that turned out to be gestational trophoblastic neoplasia (GTN) [GTN moles] and CHMs that regressed spontaneously after evacuation [remission moles]. The secondary aim was to study the profiles of miRNA expressions in CHMs. Methods: A case-control study was conducted on GTN moles and remission moles. We quantitatively assessed the expression of 800 human miRNAs from molar tissues using Nanostring nCounter. Results: From a pilot study, 21 miRNAs were significantly downregulated in GTN moles compared to the remission moles. Five of them (miR-566, miR-608, miR-1226-3p, miR-548ar-3p and miR-514a-3p) were downregulated for >4 folds. MiR-608 was selected as a candidate for further analysis on 18 CHMs (9 remission moles and 9 GTN moles) due to its striking association with malignant formation. MiR-608 expression was slightly lower in GTN moles compared to the remission moles, that is, 2.22 folds change [p = 0.063]. Conclusion: We identified 21 miRNAs that were differentially expressed between GTN moles and remission moles suggesting that miRNA profiles can distinguish between the two groups. Although not reaching statistically significant, miR-608 expression was slightly lower in GTN moles compared to remission moles.

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“…The reported incidence of hydatidiform mole is high in Asia. At King Chulalongkorn Memorial Hospital (KCMH), Bangkok, Thailand, the reported incidence is approximately 1 in 600 pregnancies (Wairachpanich et al, 2015). Majority of patients with hydatidiform mole have spontaneous regression after evacuation.…”

Section: Introductionmentioning

confidence: 99%

Role of P57KIP2 Immunohistochemical Expression in Histological Diagnosis of Hydatidiform Moles

Triratanachat

Nakaporntham²,

Tantbírójn³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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Purpose: To determine the significance of P57KIP2 immunohistochemistry expression in the histopathological diagnosis of hydatidiform mole. Materials and Methods: Hydatidiform mole patients at King Chulalongkorn Memorial Hospital between January 1999 and December 2011 were recruited. Two gynecologic pathologists reviewed histopathologic slides to confirm diagnosis. Formalin-fixed, paraffin-embedded tissue sections were stained using a bstandard immunostaining system with monoclonal antibodies against P57KIP2 protein. Correlations among pathological features, immunohistochemical expression and clinical data were analyzed.Results: One hundred and twenty-seven hydatidiform mole patients were enrolled. After consensus review, 97 cases were diagnosed as complet (CHM) and 30 cases as partial (PHM). Discordance between the first and final H&E diagnoses was found in 19 cases (14.9%, k= 0.578). Significant pathological features to classify the type of hydatidiform mole are central cisterns, trophoblastic proliferation, trophoblastic atypia, two populations of villi, fetal vessels and scalloped borders. After performing immunohistochemistry for P57KIP2, 107 cases were P57KIP2 negative and 20 cases positive. Discordant diagnoses between final H&E diagnosis and P57KIP2 immunohistochemistry was identified in 12 cases (9.4%). Sensitivity of final H&E diagnosis for CHM was 89.7%; specificity was 95.0%. PHM sensitivity and specificity of final H&E diagnosis was 95.0% and 89.7%, respectively. Conclusions: Histopathological diagnosis alone has certain limitations in accurately defining types of hydatidiform mole; P57KIP2 immunohistochemistry is practical and can be a useful adjunct to histopathology to distinguish CHM from non-CHM.

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Epidemiology of Hydatidiform Moles in a Tertiary Hospital in Thailand over Two Decades: Impact of the National Health Policy

Cited by 5 publications

References 13 publications

The current situation of health services for hydatidiform mole in Cambodia

The current situation of health services for hydatidiform mole in Cambodia

MicroRNA Expression Profiling in Hydatidiform Mole for the Prediction of Postmolar GTN

Role of P57KIP2 Immunohistochemical Expression in Histological Diagnosis of Hydatidiform Moles

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