Epidemiology of human papillomavirus-related oropharyngeal cancer in a classically low-burden region of southern Europe

Abstract

The incidence of human papillomavirus (HPV)-related oropharyngeal cancer is increasing in some regions. Nevertheless, the epidemiology of this disease has not been extensively investigated in southern europe. We conducted a retrospective cohort study of patients diagnosed with primary oropharyngeal cancer from 1991 to 2016. Cancer tissues underwent histopathological evaluation, DNA quality control, HPV-DNA detection and p16 INK4a immunohistochemistry. Data were collected from medical records. Factors associated with HPV positivity and time trends were evaluated with multivariable Bayesian models. The adjusted prevalence of HPV-related cases in 864 patients with a valid HPV-DNA result was 9.7%, with HPV-DNA/p16 INK4a double positivity being considered. HPVrelated oropharyngeal cancer was likely to occur in non-smokers and non-drinkers, to be located in the tonsil or diagnosed at advanced stages. Time-trend analysis showed an increasing risk of HPV-related oropharyngeal cancer in the most recent periods (5-year period increase of 30%). This increase was highest and with a clear increasing trend only in the most recent years (2012-2016). The prevalence of HPV-related oropharyngeal cancer started to sharply increase in the most recent years in our setting,

Prognostic significance of human papillomavirus 16 viral load level in patients with oropharyngeal cancer

“…Previous studies also showed less favorable survival of p16 + /HPV DNA − cases. 8 , 9 , 10 , 11 , 12 , 13 However, information on the prognostic value of p16 + /HPV DNA − OPSCC is limited, especially in Asian populations. To our knowledge, only one study on Japanese patients showed that p16 + /HPV DNA − cases displayed OS similar to that of p16 + /HPV DNA + cases.…”

“…However, a subset of HPV‐positive patients, determined using this method, have poor outcomes. 8 , 9 , 10 , 11 , 12 , 13 Therefore, it is imperative to refine tools for improved risk stratification of HPV‐positive patients.…”

“…When the HPV DNA low cases were added to the HPV DNA − cases, this proportion increased to 33%. Previous studies also showed less favorable survival of p16 + /HPV DNA − cases [8][9][10][11][12][13]. However, information on the prognostic value of p16 + /HPV DNA − OPSCC is limited, especially in Asian populations.…”

Factores asociados a la aceptabilidad de la vacuna contra el virus del papiloma humano, Huánuco, Perú

“…están infectadas por el VPH y 14 millones se infectan cada año. En el sur de Europa las estimaciones actuales de la prevalencia del VPH son relativamente bajas (9-24%) 3,4 .…”

Staging of human papilloma virus related cancers of the oropharynx

“…Since the discovery that a subset of oropharyngeal cancers is related to the human papilloma virus (HPV), the knowledge about this unique entity has grown exponentially, [1][2][3] and the incidence is continually increasing worldwide. [4][5][6][7] In addition, due to the observation of a biologically distinct and favorable natural history and excellent response to therapy for HPV-related cancers, a separate staging system has been introduced for these tumors in the latest edition of the American Joint Committee on Cancer (AJCC eighth Ed). 8,9 2 | Rationale for a specific HPV-related oropharynx cancer staging system There are multiple facts that led to the development of a separate staging system for HPV-positive tumors.…”