Epidemiology of Hodgkin's Lymphoma

Al‐Tonbary, Youssef

doi:10.5772/31547

Cited by 2 publications

(2 citation statements)

References 78 publications

(66 reference statements)

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“…15 Begitu juga dengan kepustakaan lain yang menyebutkan hal serupa seperti penelitian yang dilakukan oleh Salati (2014), Al-Tonbary (2012), Huh (2012), Mohammedzaki (2019). 3,7,22,23 Akan tetapi, setelah dilakukan analisis statistik pada penelitian ini, tidak didapatkan hubungan antara jenis kelamin dengan kepadatan TAMs (p=0,766). Hal ini sesuai dengan penelitian yang dilakukan oleh Bedewy, et al yang menyatakan bahwa tidak terdapat hubungan antara kepadatan CD163 dengan jenis kelamin (p=0,428).…”

Section: Diskusiunclassified

Relationship between Tumor-Associated-Macrophages and Tumor-Associated-Neutrophils Density with Clinicohistopathological Characteristics of Hodgkin's Lymphoma Patients

Putri¹,

Neti²,

Rasyid³

et al. 2021

MPI

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BackgroundThe development and aggressiveness of tumor cells were influenced by tumor microenvironment. Tumor-Associated-Macrophages(TAMs) and Tumor-Associated-Neutrophils (TANs) are components of tumor microenvironment, contribute to development and growthof tumor cells. The aim of this research was to analyse correlation of TAMs and TANs densities with clinicohistopathologiccharacteristics of patients i.e. age, gender, location, and subtype.MethodsA case series was conducted. The samples were paraffin blocks of Hodgkin lymphoma patients at Anatomic Pathology DepartmentFaculty of Medicine Universitas Sriwijaya/RSUP Dr. Mohammad Hoesin Palembang. Among 44 cases of Hodgkin lymphomadiagnosed from 1stJanuari 2015 to 30th October 2019, only 31 cases were included. Immunohistochemistry was performed by usinganti-CD163 antibody and neutrophils were identified by morphologic appearances. The results were correlated to characteristicfactors. Statistical analysis was performed using Spearman and Lambda test with significant consideration if p<0.05.ResultsThe study results showed 30 cases of classical Hodgkin lymphoma (CHL) and 1 case of NLPHL. CHL has only 3 variants LR(lymphocyte-rich) (60%), MC (mixed-cellularity) (26.7%), and NS (nodular sclerosis) (13.3%). Hodgkin lymphoma is most commonlyfound in males (61.3%). Tumor were mostly found in the head and neck, and patient ages were majority in the age group 20-29 years,40-49 years, and over 50 years. Spearman test showed there was a significant correlation between density of TAMs with ages(p=0.043).ConclusionHigh density of TAM was correlated with age, however, there was no correlation between TAN and clinicohistopathologiccharacteristics of Hodgkin lymphoma.

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Section: Diskusiunclassified

Relationship between Tumor-Associated-Macrophages and Tumor-Associated-Neutrophils Density with Clinicohistopathological Characteristics of Hodgkin's Lymphoma Patients

Putri¹,

Neti²,

Rasyid³

et al. 2021

MPI

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“…Angka kematian juga tergolong rendah karena mempunyai respons yang baik terhadap terapi. 1 Limfoma Hodgkin dapat diklasifikasikan menjadi 2 kelompok yaitu classical Hodgkin Lymphoma (cHL) dan nodular lymphocyte predominant hodgkin Lymphoma (NLPHL). cHL dibagi lagi menjadi 4 subtipe yaitu nodular sclerosis, mixed celllularity, lymphocyte-depleted dan lymphocyte-rich classical.…”

Section: Pendahuluanunclassified

Problema Diagnostik dan Respons Kemoterapi pada Seorang Penderita Classical Limfoma Hodgkin Tipe Mixed Cellularity dengan Temporary Spontaneus Regression

Maranatha

Bestari

2019

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Background: Mixed cellularity classical hodgkin lymphoma (MCCHL) is the secound subtype of classical hodgkin lymphoma (cHL) which often happens. MCCHL is aggressive but has a relatively high recovery rate. The diagnosis of cHL is sometimes difficult. Spontaneous regression can occur in cHL but is very rare, temporary or permanent. CHL including diseases with a fairly high cure rate, about 80% of patients recover with first-line chemotherapy. Case: Male age 26 years, 9 months cough, shortness of breath, chest pain 8 months, 6 months fever disappear with enlargement of right supraclavicular lymph nodes appearing at 11 days before admission. Chest X-ray shows the presence of mediastinal mass supported by contrast thoracic CT scan. FNAB has been done three times with no meaningful results. In one of the chest radiographs and CT scan of the thoracic with contrast evaluation showed a reduction in tumor size. Open thoracotomy biopsy is performed with Hodgkin’s lymphoma results. On immunohistochemical examination obtained MCCHL. Chemotherapy with ABVD regimen was administered for three cycles with partial remission and was continued with 6 cycles with stable disease outcomes. Conclusion: Spontaneous temporary regression in cases with mediastinal tumor suspicion may occur in cHL and may cause difficulties in diagnosing. Open biopsy is required as a gold standard and has to be supported by immunohistochemical test. First-line chemotherapy response in cHL is good.Background: Mixed cellularity classical hodgkin lymphoma (MCCHL) is the secound subtype of classical hodgkin lymphoma (cHL) which often happens. MCCHL is aggressive but has a relatively high recovery rate. The diagnosis of cHL is sometimes difficult. Spontaneous regression can occur in cHL but is very rare, temporary or permanent. CHL including diseases with a fairly high cure rate, about 80% of patients recover with first-line chemotherapy. Case: Male age 26 years, 9 months cough, shortness of breath, chest pain 8 months, 6 months fever disappear with enlargement of right supraclavicular lymph nodes appearing at 11 days before admission. Chest X-ray shows the presence of mediastinal mass supported by contrast thoracic CT scan. FNAB has been done three times with no meaningful results. In one of the chest radiographs and CT scan of the thoracic with contrast evaluation showed a reduction in tumor size. Open thoracotomy biopsy is performed with Hodgkin’s lymphoma results. On immunohistochemical examination obtained MCCHL. Chemotherapy with ABVD regimen was administered for three cycles with partial remission and was continued with 6 cycles with stable disease outcomes. Conclusion: Spontaneous temporary regression in cases with mediastinal tumor suspicion may occur in cHL and may cause difficulties in diagnosing. Open biopsy is required as a gold standard and has to be supported by immunohistochemical test. First-line chemotherapy response in cHL is good.

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Epidemiology of Hodgkin's Lymphoma

Cited by 2 publications

References 78 publications

Relationship between Tumor-Associated-Macrophages and Tumor-Associated-Neutrophils Density with Clinicohistopathological Characteristics of Hodgkin's Lymphoma Patients

Relationship between Tumor-Associated-Macrophages and Tumor-Associated-Neutrophils Density with Clinicohistopathological Characteristics of Hodgkin's Lymphoma Patients

Problema Diagnostik dan Respons Kemoterapi pada Seorang Penderita Classical Limfoma Hodgkin Tipe Mixed Cellularity dengan Temporary Spontaneus Regression

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