Epidemiology of hepatitis C virus infection among injection drug users in China: Systematic review and meta-analysis

Xia, Xian; Luo, Jun; Bai, Jianling; Yu, Rongbin

doi:10.1016/j.puhe.2008.01.014

Cited by 134 publications

(144 citation statements)

References 31 publications

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“…Duration of injection drug use (> 10 years) has been reported as a risk factor in another study in Iran (13). These findings are consistent with the results reported in other countries (22,25,29,33,34). However, we found an HCV seroprevalence of 18.2% among IDUs who had been injecting drugs for less than two years.…”

Section: Variables Correlated With Hepatitis Csupporting

confidence: 90%

“…A similar finding has been reported in England, in which female gender was identified as a risk factor for HCV infection (24). Other studies have not identified such a relationship (25,26). Several social and demographic factors may predispose female drug users to acquiring blood-borne infections.…”

Section: Variables Correlated With Hepatitis Csupporting

confidence: 76%

“…Studies conducted in countries in this region, such as Pakistan (39) and Georgia (40), have reported unsafe injection to be the main cause of hepatitis C transmission among their populations. However, a meta-analysis of the factors correlated with HCV in China showed no significant difference between needle-sharing IDUs and non-needlesharing IDUs (25). In our study, sharing behavior during the last six months was reversely associated with HCV infection.…”

Section: Variables Correlated With Hepatitis Ccontrasting

confidence: 65%

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Factors Correlated With Hepatitis C and B Virus Infections Among Injecting Drug Users in Tehran, IR Iran

et al. 2012

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This article presents that IDUs are highly at risk of hepatitis B and C virus infections. This has an important implication for those who are involved in planning for providing harm reduction services, especially in prison settings. Background:In Iran, the number of injecting drug users (IDUs) has increased in recent years. The rates of hepatitis C virus (HCV) and hepatitis B virus (HBV) infections among IDUs are reportedly high. Objectives: The purpose of this study was to assess factors correlated with HCV and HBV infections among IDUs in Tehran. Patients and Methods: A cross-sectional study included 899 IDUs recruited from the community, drug treatment centers, and drop-in-centers. The study involved interviews conducted using an adapted version of the WHO Drug Injection Study Phase II (Version 2b) questionnaire and blood testing for the HCV antibody, hepatitis B surface antigen, and hepatitis B core antibody. A logistic regression model was used to identify independent factors correlated with HCV and HBV infections. Results: HCV infection was found to be primarily associated with female gender [odds ratio (OR) 5.0, 95% confidence interval (CI) 2.0-10.0)], unmarried status (OR 2.9, 95% CI 1.9-4.4), drug use for more than 10 years (OR 2.7, 95% CI 1.8-3.9), drug injection frequency of more than once per day (OR 2.6, 95% CI 1.6-4.2), history of imprisonment (OR 2.5, 95% CI 1.6-4.0)], and a history of shared injection needles in prison (OR 2.3, 95% CI 1.5-3.6). HBV infection was mainly correlated with a history of imprisonment (OR 1.9, 95% CI 1.4-2.7) and drug use for more than 10 years (OR 1.4, 95% CI 1.1-1.9). Conclusions: Because a considerable number of IDUs in Iran are receiving reduction services, tailoring services for prevention of hepatitis infection are necessary.

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Section: Variables Correlated With Hepatitis Csupporting

confidence: 90%

Section: Variables Correlated With Hepatitis Csupporting

confidence: 76%

Section: Variables Correlated With Hepatitis Ccontrasting

confidence: 65%

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Factors Correlated With Hepatitis C and B Virus Infections Among Injecting Drug Users in Tehran, IR Iran

et al. 2012

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“…Another study reported that HCV is transmitted primarily by direct contact with infected blood and transfusion of blood products and intravenous and percutaneous drug use [33]. Nemati et al reported that shaving by community barbers, unsafe injections by health care providers, tattooing and ear piercing, known to be associated with HCV infection [34], but in our study all except IV injection were non statistically significant.…”

contrasting

confidence: 67%

Prevalence of hepatitis B and C among some high risk groups in Egyptian children attending Benha University hospital.

Elsherbiny¹,

Abed²,

Mohammed³

et al. 2017

IJAR

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Background: Hepatitis C virus (HCV) is a global health problem especially in Egypt. Hepatitis B virus (HBV) is a major cause of chronic liver diseases especially cirrhosis and hepatocellular carcinoma. HBV incidence is markedly reduced after mass vaccination programs application. Objectives: to detect HCV and HBV seroprevalence among some high risk children with molecular confirmation of viremia by real-time PCR for seropositive cases. Materials and methods: A comparative cross sectional study was conducted on 5 groups of Egyptian children attending Benha University Hospital (diabetes mellitus, thalassemia, hemodialysis, previously exposed to surgery and healthy children). All children were subjected to full history taking, physical examination and laboratory investigations including HCV antibodies by 4 th generation ELISA, HBsAg, HBsAb using ELISA, liver function tests and CBC, HCV and HBV viremia detection by real-time PCR for ELISA positive subjects. Results: HCV seropositivity was detected in 5%, 15%, 30%, 50% and 10% for healthy, diabetic, thalassemia, hemodialysis and previously exposed to surgery, respectively. As regard HBV, only a hemodialysis case was positive for both HBsAg and HBV-DNA. Low social class, blood transfusion, frequent intravenous injection, previous surgery and previous hospitalization are major risk factors for HCV transmission. Conclusion:The study revealed high HCV seropositivity prevalence among the studied high risk groups. PCR should be done for all HCV seropositive cases to confirm the presence of viremia.

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“…Numerous studies documented prevalence of hepatitis C infection. [5][6][7][8][9][10][11][12][13][14][15][16][17] Diverse HCV prevalence rates worldwide could be explained by the different risk factors involved. [18][19][20] At national level, HCV prevalence among general population and high risk groups was reported.…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of hepatitis C viral infection in Faisalabad, Pakistan: a retrospective study (2010-2012)

Maan¹,

Hussain²,

Jamil³

2015

Afr H. Sci.

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Abstract:Background: Hepatitis viral infections are major health challenge leading to high morbidity and mortality worldwide. Objectives: Although the magnitude of hepatitis in Pakistan has been well documented, information regarding the prevalence of hepatitis C virus (HCV) infection in Faisalabad, Pakistan is scarce. The present retrospective study was undertaken to determine the epidemiology of HCV in Faisalabad, Pakistan. Methods: Between May, 2010 and December, 2012, medical records of 39780 subjects visiting sexually transmitted infections (STIs) clinic, district headquarter (DHQ) hospital, Faisalabad, Pakistan were reviewed. Regression analysis was used to determine independent risk factors Results: HCV prevalence was 21.99%. With mean age of 49.5 ± 2.7 years (range 27-63 years), majority (67.15%) of the individuals were male. Marital status and low literacy rates were associated with HCV (P<0.05). Reference to the potential risk factors, the injection drug use was the major mode (72.77%) of infection transmission. Age (OR 1.5, 95% CI 1.2-1.9), male gender (OR 1.2, 95% CI 0.9-1.6) and injection use (OR 1.9, 95% CI 1.0-2.7) were significantly associated with HCV. Conclusions: Most important finding was higher HCV prevalence in Faisalabad region as compared to the previous assessments that demands an urgent need for preventive intervention strategies.

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Epidemiology of hepatitis C virus infection among injection drug users in China: Systematic review and meta-analysis

Cited by 134 publications

References 31 publications

Factors Correlated With Hepatitis C and B Virus Infections Among Injecting Drug Users in Tehran, IR Iran

Factors Correlated With Hepatitis C and B Virus Infections Among Injecting Drug Users in Tehran, IR Iran

Prevalence of hepatitis B and C among some high risk groups in Egyptian children attending Benha University hospital.

Epidemiology of hepatitis C viral infection in Faisalabad, Pakistan: a retrospective study (2010-2012)

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