Epidemiology of hepatitis B virus infection: results from a community-based study of 0.15 million residents in South China

Zeng, Fangfang; Guo, Pi; Huang, Yun; Wei, Xin; Du, Zhicheng; Zhu, Shuqian; Deng, Yu; Zhang, Dingmei

doi:10.1038/srep36186

Cited by 47 publications

(32 citation statements)

References 29 publications

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“…Having a history of trauma was also a risk factor for HBV and HCV which was also reported in another study 27 . Trauma increases the risk of medical interventions and exposure to blood and blood products which could increase the risk of HBV and HCV 28 . Improving the trauma services would reduce this risk.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Hepatitis B and Hepatitis C Virus Infections at Premarital Screening Program in Duhok, Iraq

Ramadhan

2018

DMJ

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Background: Viral hepatitis causes increasing mortality worldwide despite all the efforts to control this health problem. Premarital screening program provides an opportunity to detect and manage hepatitis B and hepatitis C viruses. Determination of a carrier status during premarital testing will create awareness between the couples and lead to the protection of the prospective spouse by early vaccination or treatment. The objective of this study is to determine the prevalence of hepatitis B and hepatitis C virus infections among premarital couples in Duhok, Iraq. Subject and Methods: This cross-sectional study was conducted from August 2016 to April 2017 in the clinic and laboratory of the premarital screening program within the preventive health affairs in Duhok-Iraq. The sample size was 2000 persons (1000 males and 1000 females). All persons were tested for HBs Ag, total anti-HBc, and anti-HCV. Results: The age ranged from 14 years to 75 years with a mean of 25.1 years (95% CI = 24.8-25.4 years). The prevalence of HBV infection was 1.1% (N=22), isolated anti-HBc as 3.1% (N=62) and HCV seropositivity was 0.2% (N=4).The factors associated with HBV and HCV were being a health professional (P <0.001), having a history of trauma (P =0.003) and having a family history of HBV or HCV (P<0.001). Conclusions: The prevalence of HBV infection, isolated anti-HBc, and HCV seropositivity is low among the premarital people. Including total anti-HBc in the current premarital screening program will detected anti-HBc which helps in the efforts to control and manage HBV.

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Section: Discussionmentioning

confidence: 99%

Prevalence of Hepatitis B and Hepatitis C Virus Infections at Premarital Screening Program in Duhok, Iraq

Ramadhan

2018

DMJ

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“…Hepatitis B virus infection is an important risk factor for the development of primary hepatocellular carcinoma [ 2 ]. The incidence of hepatitis B virus infection in China is high, resulting in high morbidity from hepatic carcinoma [ 2 , 3 ]. Primary hepatocellular carcinoma is characterized by high malignancy and metastasis and poor prognosis.…”

Section: Introductionmentioning

confidence: 99%

Serum AFU, 5’-NT and AFP as biomarkers for primary hepatocellular carcinoma diagnosis

et al. 2017

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AbstractTo evaluate the clinical value of serum α-L-fucosidase (AFU), 5’-nucleotidase (5’-NT) and alpha fetoprotein (AFP) as biomarkers for primary hepatocellular carcinoma (PHC) diagnosis. Methods: Thirty six primary hepatocellular carcinoma (PHC) patients and 36 healthy controls were recruited in this study from February 2014 to January 2016 in the Second People’s Hospital of Tianjin. The serum level of AFU, 5’-NT and AFP were examined and compared between the two groups. The diagnostic sensitivity, specificity area under the receiver operating characteristic (ROC) curve were calculated by STATA11.0 software. Results: The serum level of AFU, 5’-NT, AFP were 30.87±10.43(U/L), 5.58±3.89(U/L), 233.60±226.60 (μg/L) respectively for primary hepatocellular carcinoma group and 19.96±6.73 (U/L), 1.87±0.84 (U/L), 16.64±14.17 (μg/L) for healthy control groups. The serum level of AFU, 5’-NT and AFP in primary hepatocellular carcinoma group were significant higher than those of healthy control group (P<0.001). The diagnostic sensitivity and specificity were 0.78 (95%CI:l0.61-0.90), 0.64 (95%CI:0.46-0.79) for serum AFU, 0.75(95%CI:0.58-0.88), 0.72(95%CI:0.55- 0.86) for serum 5’-NT and 0.72 (95%CI:0.55-0.86), 0.92 (95%CI:0.78-0.98) for serum AFP respectively. The AUC under the ROC curve were 0.80 (0.69-0.90), 0.80 (0.69-0.91) and 0.87 (0.780-0.96) for serum AFU, 5’-NT and AFP respectively. Positive correlation between AFU and 5’-NT (rpearson=0.63, P<0.05), AFU and AFP (rpearson=0.49, P<0.05), 5’-NT and AFP(rpearson=0.44, P<0.05) were found in the primary hepatocellular carcinoma patients. Conclusion: Serum AFU, 5’-NT and AFP were higher in PHC patients than those of healthy controls. The difference between PHC patients and healthy controls made serum AFU, 5’-NT and AFP potential biomarker for PHC diagnosis.

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“…There may be an in uence of estrogen in the protection and defense of hepatic cells against the development of chronic liver disease [44]. In Zeng et al study married people had the highest prevalence of HBsAg [45], on the other hand in Ataei et al study in Isfahan province no statistical difference observed in terms of marital status, but males (OR= 3.79) had a higher prevalence of HBV than women [46].…”

Section: Discussionmentioning

confidence: 99%

Epidemiologic profile of viral hepatitis B and C in North of Iran: Results from PERSIAN Guilan Cohort Study (PGCS)

Mansour‐Ghanaei

Joukar

Naghipour

et al. 2020

Preprint

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Objective Hepatitis B (HBV) and C (HCV) viruses are two severe infectious diseases with a high global health impact. This study aimed to evaluate the prevalence of HBV and HCV in the Prospective Epidemiological Research Studies of the Iranian Adults (PERSIAN) Guilan Cohort Study through immunological and molecular methods. Results The blood samples were obtained from 10520 enrolled participants. Complete biochemical and hematological assessments plus urine analysis were done. The presence of HBsAg, anti-HBs, anti-HBc, and anti-HCV antibodies for all participants and HBeAg and anti-HBe antibody for HBV positive patients were evaluated. HBV genomic DNA and HCV genomic RNA were extracted from positive serum samples. The real-time PCR assay was done to quantify HBV and HCV genomes. HCV genotyping was also performed. The HBV and HCV prevalence was 0.24% (95% CI, 0.16% to 0.35%) and 0.11% (95% CI, 0.06% to 0.19%), respectively. Rural participants were significantly more HBV positive than urban peoples (P = 0.045) while male individuals were significantly more HCV positive than female participants (P = 0.013). Our detected HBV and HCV prevalence were lower than other cities/provinces of Iran, which may be due to lifestyle or other unknown reasons.

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Epidemiology of hepatitis B virus infection: results from a community-based study of 0.15 million residents in South China

Cited by 47 publications

References 29 publications

Prevalence of Hepatitis B and Hepatitis C Virus Infections at Premarital Screening Program in Duhok, Iraq

Prevalence of Hepatitis B and Hepatitis C Virus Infections at Premarital Screening Program in Duhok, Iraq

Serum AFU, 5’-NT and AFP as biomarkers for primary hepatocellular carcinoma diagnosis

Epidemiologic profile of viral hepatitis B and C in North of Iran: Results from PERSIAN Guilan Cohort Study (PGCS)

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